indolizine-1,2,3-triyltris((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanone) | 1393956-11-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: indolizine-1,2,3-triyltris((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanone)
• 英文别名: [2,3-Bis(2,3-dihydro-1,4-benzodioxine-6-carbonyl)indolizin-1-yl]-(2,3-dihydro-1,4-benzodioxin-6-yl)methanone；[2,3-bis(2,3-dihydro-1,4-benzodioxine-6-carbonyl)indolizin-1-yl]-(2,3-dihydro-1,4-benzodioxin-6-yl)methanone
• CAS: 1393956-11-0
• 化学式: C₃₅H₂₅NO₉
• 分子量: 603.585
• InChiKey: WCWDHWIVQONFQH-UHFFFAOYSA-N

物化性质

• 熔点：
  211-213 °C
• 密度：
  1.47±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  45
• 可旋转键数：
  6
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  111
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  吡啶 、 6-乙酰基-1,4-苯并二氧杂环 在 碘 、 二甲基亚砜 作用下， 反应 36.0h， 以73%的产率得到indolizine-1,2,3-triyltris((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanone)
  参考文献：
  名称：

  Convergent domino synthesis of 1,2,3-triaroylindolizines from methyl ketones and pyridines via self-division of labor strategy

  摘要：

  A highly efficient method for the synthesis of 1,2,3-triaroylindolizines has been established from readily available methyl ketones and pyridines in the presence of iodine. This reaction also examplified the self-division of labor strategy in convergent domino synthesis. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.06.091

文献信息

• Convergent domino synthesis of 1,2,3-triaroylindolizines from methyl ketones and pyridines via self-division of labor strategy
  作者：Yan Yang、Meng Gao、Dong-Xue Zhang、Liu-Ming Wu、Wen-Ming Shu、An-Xin Wu

  DOI：10.1016/j.tet.2012.06.091

  日期：2012.9

  A highly efficient method for the synthesis of 1,2,3-triaroylindolizines has been established from readily available methyl ketones and pyridines in the presence of iodine. This reaction also examplified the self-division of labor strategy in convergent domino synthesis. (C) 2012 Elsevier Ltd. All rights reserved.