3'-O-triisopropylsilyl-5'-O-(4,4'-dimethoxytrityl)thymidine | 167147-49-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 3'-O-triisopropylsilyl-5'-O-(4,4'-dimethoxytrityl)thymidine
• 英文别名: 1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-tri(propan-2-yl)silyloxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
• CAS: 167147-49-1
• 化学式: C₄₀H₅₂N₂O₇Si
• 分子量: 700.948
• InChiKey: LGLVLCBCERZRTR-HKIDPNTFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.72
• 重原子数：
  50
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  95.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  三氟乙酸 、 3'-O-triisopropylsilyl-5'-O-(4,4'-dimethoxytrityl)thymidine 、 吡啶 在 ice 、 碳酸氢钠 、 Sodium sulfate-III 、 silica gel 作用下， 以 氯仿 为溶剂， 反应 0.17h， 以to give 0.9965 g (yield 94%) of the title compound的产率得到O^3'-triisopropylsilanyl-thymidine
  参考文献：
  名称：

  Composition and method for the treatment or prophylaxis of viral

  摘要：

  提供了哺乳动物，如人类的病毒感染的组合物和治疗或预防方法。组合物中的化合物以及在方法中被管理的化合物是公式（1）的寡脱氧核糖核酸衍生物：##STR1##其中R.sub.1，R.sub.2和R.sub.3是氢原子，烷基，芳基和蒽醌基；Z是碳或硅；或R.sub.2，R.sub.3和Z一起代表芴基或黄酮基；R.sub.4是氢原子，烷基或芳基；Y.sub.1，Y.sub.3和Y.sub.4是氧，硫或>NH；Y.sub.2是氧，硫，>NH，烷基或苯基；X是烷基；m和n分别为0至10；B是链长为3至9的寡脱氧核糖核酸或其盐。

  公开号：

  US05807837A1
• 作为产物：
  描述：

  三异丙基氯硅烷 、 保护胸苷 在 N-甲基咪唑 、 碘 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 生成 3'-O-triisopropylsilyl-5'-O-(4,4'-dimethoxytrityl)thymidine
  参考文献：
  名称：

  Iodine-promoted silylation of alcohols with silyl chlorides. Synthetic and mechanistic studies

  摘要：

  An efficient silylating system for 1 degrees, 2 degrees, and 3 degrees, alcohols, consisting of a silyl chloride/N-methylimidazole/iodine, was developed. Synthetic and mechanistic aspects of this new reagent system, and particularly the role of iodine were investigated in detail using H-1 NMR spectroscopy. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.06.070

文献信息

• Modified oligodeoxyribonucleoditides
  申请人：Sankyo Company, Limited

  公开号：US05674856A1

  公开（公告）日：1997-10-07

  Compounds for the treatment or prophylaxis of a viral infection in a mammal, which may be human, are provided. The compounds are oligodeoxyribonucleic acid derivatives, and a novel route to such compounds is also provided together with intermediates of more general utility. The active compounds are of the general formula (1): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms, alkyl groups, aryl groups as defined, and anthraquinonyl groups as defined; Z is carbon or silicon; or R.sub.2, R.sub.3 and Z together represent fluorenyl or xanthenyl; R.sub.4 is a hydrogen atom, an alkyl group as defined, an aryl group as defined; Y.sub.1, Y.sub.3 and Y.sub.4 are oxygen, sulfur or >NH; Y.sub.2 is oxygen, sulfur, >NH, alkylene or phenylene; X is alkylene group as defined; m and n are 0 to 10; and B is an oligodeoxyribonucleotide of chain length 3 to 9; or salts thereof.

  提供用于治疗或预防哺乳动物（可能是人类）病毒感染的化合物。这些化合物是寡脱氧核糖核酸衍生物，并提供了一种新颖的合成这些化合物的途径，以及更普遍有用的中间体。活性化合物的一般结构式为（1）：其中R.sub.1、R.sub.2和R.sub.3是氢原子、烷基、所定义的芳基和蒽醌基；Z是碳或硅；或者R.sub.2、R.sub.3和Z一起代表芴基或蒽基；R.sub.4是氢原子、所定义的烷基、所定义的芳基；Y.sub.1、Y.sub.3和Y.sub.4是氧、硫或>NH；Y.sub.2是氧、硫、>NH、烷基或苯基；X是所定义的烷基；m和n为0至10；B是链长为3至9的寡脱氧核糖核苷酸；或其盐。
• Iodine-promoted silylation of alcohols with silyl chlorides. Synthetic and mechanistic studies
  作者：Agnieszka Bartoszewicz、Marcin Kalek、Jacek Stawinski

  DOI：10.1016/j.tet.2008.06.070

  日期：2008.9

  An efficient silylating system for 1 degrees, 2 degrees, and 3 degrees, alcohols, consisting of a silyl chloride/N-methylimidazole/iodine, was developed. Synthetic and mechanistic aspects of this new reagent system, and particularly the role of iodine were investigated in detail using H-1 NMR spectroscopy. (C) 2008 Elsevier Ltd. All rights reserved.
• Composition and method for the treatment or prophylaxis of viral
  申请人：Sankyo Company, Limited

  公开号：US05807837A1

  公开（公告）日：1998-09-15

  A composition and method of treatment or prophylaxis of a viral infection in a mammal, such as a human, are provided. The compounds in the composition and which are administered in the method, are oligodeoxyribonucleic acid derivatives of the formula (1): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms, alkyl groups, aryl groups, and anthraquinonyl groups; Z is carbon or silicon; or R.sub.2, R.sub.3 and Z together represent fluorenyl or xanthenyl; R.sub.4 is a hydrogen atom, an alkyl group or an aryl group; Y.sub.1, Y.sub.3 and Y.sub.4 are oxygen, sulfur or >NH; Y.sub.2 is oxygen, sulfur, >NH, alkylene or phenylene; X is an alkylene group; m and n are each 0 to 10; and B is an oligodeoxyribonucleotide of a chain length of 3 to 9, or salts thereof.

  提供了哺乳动物，如人类的病毒感染的组合物和治疗或预防方法。组合物中的化合物以及在方法中被管理的化合物是公式（1）的寡脱氧核糖核酸衍生物：##STR1##其中R.sub.1，R.sub.2和R.sub.3是氢原子，烷基，芳基和蒽醌基；Z是碳或硅；或R.sub.2，R.sub.3和Z一起代表芴基或黄酮基；R.sub.4是氢原子，烷基或芳基；Y.sub.1，Y.sub.3和Y.sub.4是氧，硫或>NH；Y.sub.2是氧，硫，>NH，烷基或苯基；X是烷基；m和n分别为0至10；B是链长为3至9的寡脱氧核糖核酸或其盐。