2,3-di(naphth-2-yl)butane | 218131-26-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2,3-di(naphth-2-yl)butane
• 英文别名: 2,2'-(butane-2,3-diyl)dinaphthalene；dl-2,3-Bis<2-naphthyl>butan；meso-2,3-Bis<2-naphthyl>butan；2,3-di-[2]naphthyl-butane；2,3-Di-[2]naphthyl-butan；2-(3-Naphthalen-2-ylbutan-2-yl)naphthalene
• CAS: 218131-26-1
• 化学式: C₂₄H₂₂
• 分子量: 310.439
• InChiKey: IYJXLPLPTKMKAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  (+/-)-1-(2-naphthyl)ethyl benzyl sulfone 生成 2,3-di(naphth-2-yl)butane
  参考文献：
  名称：

  GIVENS, R. S.;HRINCZENKO, B.;LIU, J. H. -S.;MATUSZEWSKI, B.;THOLEN-COLLIS+, J. AMER. CHEM. SOC., 1984, 106, N 6, 1779-1789

  摘要：

  DOI：

文献信息

• Nickel/Photo-Cocatalyzed Regioselective Ring Opening of <i>N</i>-Tosyl Styrenyl Aziridines with Aldehydes
  作者：Pei Fan、Youxiang Jin、Jiawei Liu、Rui Wang、Chuan Wang

  DOI：10.1021/acs.orglett.1c02514

  日期：2021.10.1

  Aldehydes and aziridines are both intrinsic electrophilic reagents, and thus the coupling reaction between these two compounds is highly challenging. In this protocol, the merger of nickel and hydrogen-atom-transfer photocatalysis successfully enables the ring opening of N-tosyl styrenyl aziridines with aldehydes, providing a novel and atom-economical access to a variety of β-amino ketones with complete

  醛和氮丙啶都是固有的亲电试剂，因此这两种化合物之间的偶联反应极具挑战性。在该协议中，镍和氢原子转移光催化的合并成功地使N-甲苯磺酰基苯乙烯基氮丙啶与醛开环，为获得具有完全区域控制的各种 β-氨基酮提供了一种新颖且原子经济的途径。初步机理研究表明，开环反应以协同催化模式进行：醛在辐照下被四丁基十钨酸铵转化为酰基，而镍催化剂参与氮丙啶的开环和以下碳-碳键的形成步。
• Mechanistic studies of the photodecomposition of arylmethyl sulfones in homogeneous and micellar solutions
  作者：Ian R. Gould、Chen Ho Tung、Nicholas J. Turro

  DOI：10.1021/ja00318a038

  日期：1984.3

  The mechanism of photodecomposition of aryl sulfones has been investigated by using both steady-state and time-resolved techniques. Direct evidence for radical and triplet-state intermediates is provided. A correlation is found between the dynamics of reaction of the intermediate triplet states with the stabilities of the intermediate radicals.

  使用稳态和时间分辨技术研究了芳基砜的光分解机理。提供了自由基和三重态中间体的直接证据。发现中间三重态的反应动力学与中间自由基的稳定性之间存在相关性。
• Cobalt‐Catalyzed Enantioselective Hydroamination of Arylalkenes with Secondary Amines
  作者：Huanran Miao、Meihui Guan、Tao Xiong、Ge Zhang、Qian Zhang

  DOI：10.1002/anie.202213913

  日期：2023.1.9

  An excellent enantioselective hydroamination of arylalkenes with Lewis basic secondary amines was developed, via an elegant cobalt-hydride mediated oxidative hydrogen atom transfer (MHAT) process, leading to the synthesis of a series of valuable α-chiral tertiary amines in good to excellent yields and enantioselectivities.

  通过优雅的钴氢化物介导的氧化氢原子转移 (MHAT) 过程，开发了芳基烯烃与路易斯碱性仲胺的出色对映选择性加氢胺化反应，从而以良好至优异的产率合成了一系列有价值的 α-手性叔胺和对映选择性。
• Electroreductive formylation of activated alcohols<i>via</i>radical–polar crossover
  作者：Jungtaek Kang、Heyjin Cho、Hyunwoo Kim

  DOI：10.1039/d3cc01529g

  日期：——

  The direct synthesis of sterically hindered aldehydes is highly challenging. Herein, we report a direct approach to generate such compounds via electroreductive cleavage of the C(sp3)–O bond of activated alcohols. Under the established reaction conditions, benzylic radical intermediates were efficiently generated. A subsequent radical–polar crossover generated carbanions that further reacted with N

  空间位阻醛的直接合成极具挑战性。在此，我们报告了一种通过活化醇的 C(sp 3 )–O 键的电还原裂解生成此类化合物的直接方法。在既定的反应条件下，有效地生成了苄基自由基中间体。随后的自由基-极性交叉产生的碳负离子进一步与N , N-二甲基甲酰胺反应，形成各种具有叔或季苄基碳中心的醛。还证明了克级合成的可行性。该反应也在一个简单的未分隔电池中进行，避免使用任何过渡金属催化剂、有毒气体和还原剂。
• Methods of preparing alpha, beta-diaryl ethanes
  申请人：LILLY CO ELI

  公开号：US02392595A1

  公开（公告）日：1946-01-08