N~1~,N~4~-Didecyl-N~1~,N~1~,N~4~,N~4~-tetramethylbutane-1,4-bis(aminium) dibromide | 87723-15-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N~1~,N~4~-Didecyl-N~1~,N~1~,N~4~,N~4~-tetramethylbutane-1,4-bis(aminium) dibromide
• 英文别名: decyl-[4-[decyl(dimethyl)azaniumyl]butyl]-dimethylazanium;dibromide
• CAS: 87723-15-7
• 化学式: C28H62Br2N2
• 分子量: 586.6
• InChiKey: HKAKXBFSZZJPGZ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  2.21
• 重原子数：
  32
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,4-二溴丁烷 、 癸叔胺 以92%的产率得到
  参考文献：
  名称：

  IMAM, T.;DEVINSKY, F.;LACKO, I.;MLYNARCIK, D.;KRASNEC, L., PHARMAZIE, 1983, 38, N 5, 308-310

  摘要：

  DOI：

文献信息

• CATIONIC REAGENTS OF TRANSFECTION
  申请人：——

  公开号：US20010048939A1

  公开（公告）日：2001-12-06

  Cationic cytofectins and liposomes comprising the same are disclosed which are especially useful for delivering exogenous compounds into cells in vitro and in vivo. The liposomes may comprise (a) a neutral lipid such as dioleoylphosphatidyl-ethanolamine (DOPE) or similar lipid-like compounds such as 1,2-dioleoyl-oxiphosphatidylethanolamine or other lipid-like structures and (b) one or more of the cationic cytofectins provided herein. The invention provides transfection kits and methods for delivery of exogenous compounds into cells.

  本发明公开了阳离子细胞感染素和包含阳离子细胞感染素的脂质体，它们特别适用于在体外和体内将外源化合物输送到细胞中。脂质体可包括：(a) 中性脂质，如二油酰磷脂酰乙醇胺（DOPE）或类似的类脂化合物，如 1,2-二油酰-氧磷脂酰乙醇胺或其他类脂结构；(b) 本文提供的一种或多种阳离子细胞感染素。本发明提供了将外源化合物递送到细胞中的转染试剂盒和方法。
• Cationic reagents for transfection
  申请人：——

  公开号：US20040077582A1

  公开（公告）日：2004-04-22

  Cationic cytofectins and liposomes comprising the same are disclosed which are especially useful for delivering exogenous compounds into cells in vitro and in vivo. The liposomes may comprise (a) a neutral lipid such as dioleoylphosphatidyl-ethanolamine (DOPE) or similar lipid-like compounds such as 1,2-dioleoyl-oxiphosphatidylethanolamine or other lipid-like structures and (b) one or more of the cationic cytofectins provided herein. The invention provides transfection kits and methods for delivery of exogenous compounds into cells.

  本发明公开了阳离子细胞感染素和包含阳离子细胞感染素的脂质体，它们特别适用于在体外和体内将外源化合物输送到细胞中。脂质体可包括：(a) 中性脂质，如二油酰磷脂酰乙醇胺（DOPE）或类似的类脂化合物，如 1,2-二油酰-氧磷脂酰乙醇胺或其他类脂结构；(b) 本文提供的一种或多种阳离子细胞感染素。本发明提供了将外源化合物递送到细胞中的转染试剂盒和方法。
• CATIONIC REAGENTS FOR TRANSFECTION
  申请人：QIAGEN GmbH

  公开号：EP1003556A2

  公开（公告）日：2000-05-31
• US6733777B2
  申请人：——

  公开号：US6733777B2

  公开（公告）日：2004-05-11
• [EN] CATIONIC REAGENTS FOR TRANSFECTION<br/>[FR] REACTIFS CATIONIQUES POUR TRANSFECTION
  申请人：——

  公开号：WO1998019709A2

  公开（公告）日：1998-05-14

  [EN] The present invention relates to cationic cytofectins and liposomes comprising the same for use in delivering exogenous compounds into cells in vitro and in vivo. The liposome may comprise: (a) a neutral lipid such as dioleoylphosphatidylethanolamine (DOPE) or similar lipid-like compounds such as 1,2-dioleoyloxiphosphatidylethanolamine or other lipid-like structures and (b) one or more of the cationic cytofectins provided herein. The present invention also provides transfection kits and methods of delivery comprising the same.
  [FR] L'invention concerne des cytofectines cationiques et des liposomes comprenant lesdites cytofectines, qui permettent d'introduire des composés exogènes dans des cellules in vitro et in vivo. Le liposome peut comprendre: (a) un lipide neutre tel que la dioléoylphosphatidyléthanolamine (DOPE) ou des composés de type lipidique similaires, tels que la 1,2-dioléoyloxyphosphatidyléthanolamine ou d'autres structures de type lipidique, et (b) une ou plusieurs cytofectines cationiques décrites ici. L'invention concerne également des trousses de transfection et des méthodes de délivrance les comprenant.