8-thia-bicyclo[3.2.1]octane | 280-24-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻烷
• 英文名称: 8-thia-bicyclo[3.2.1]octane
• 英文别名: 8-Thia-bicyclo[3.2.1]octan；8-Thiabicyclo[3.2.1]octane
• CAS: 280-24-0
• 化学式: C₇H₁₂S
• 分子量: 128.238
• InChiKey: URTHIYWIPBAWNZ-UHFFFAOYSA-N

物化性质

• 熔点：
  172-173 °C
• 沸点：
  194.5 °C(Press: 769 Torr)
• 密度：
  1.047±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  8-thia-bicyclo[3.2.1]octane 、 碘甲烷 生成 8-methyl-8-thionia-bicyclo[3.2.1]octane; iodide
  参考文献：
  名称：

  Preparation and Physical Properties of Sulfur Compounds Related to Petroleum. VII. 2-, 6- and 8-Thiabicyclo[3.2.1]octane and 2-Thiabicyclo[2.2.2]octane

  摘要：

  DOI：

  10.1021/jo01363a015
• 作为产物：
  描述：

  1,3-环庚二烯 在 lithium aluminium tetrahydride 、 乙醚 、 N-苯基-2-萘胺 、 二氧化硫 、 镍 作用下， 生成 8-thia-bicyclo[3.2.1]octane
  参考文献：
  名称：

  Preparation and Physical Properties of Sulfur Compounds Related to Petroleum. VII. 2-, 6- and 8-Thiabicyclo[3.2.1]octane and 2-Thiabicyclo[2.2.2]octane

  摘要：

  DOI：

  10.1021/jo01363a015

文献信息

• PYRAZOLE COMPOUND
  申请人：Sasaki Izumi

  公开号：US20130116296A1

  公开（公告）日：2013-05-09

  The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT 2C antagonistic action (antidepressive and anxiolytic effects), in particular, 5-HT 2C inverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereof wherein R 1 , R 2 , R 3 and R 4 are independently hydrogen or C 1-6 alkyl etc.; R 5 is C 4-7 alkyl or —(CR 8 R 9 ) r -E; R 6 , R 7 , R 8 and R 9 are independently hydrogen, fluorine or C 1-6 alkyl; A is C 6-10 aryl or heteroaryl etc.; r is 1, 2, 3 or 4; E is C 3-8 cycloalkyl or C 6-10 aryl etc.; L is oxygen, sulfur or —NR 10 —; n is 1, 2 or 3; R 10 is hydrogen or C 1-6 alkyl etc.; and X is hydrogen or halogen etc.

  本发明涉及一种新型的血清素再摄取抑制剂，同时还表现出5-HT2C拮抗作用（抗抑郁和抗焦虑效果），特别是包括化合物（1）的5-HT2C逆作动作：或其药学上可接受的盐，其中R1、R2、R3和R4独立地为氢或C1-6烷基等；R5为C4-7烷基或—(CR8R9)r-E；R6、R7、R8和R9独立地为氢、氟或C1-6烷基；A为C6-10芳基或杂环芳基等；r为1、2、3或4；E为C3-8环烷基或C6-10芳基等；L为氧、硫或—NR10—；n为1、2或3；R10为氢或C1-6烷基等；X为氢或卤素等。
• [EN] MONOBACTAMS AND METHODS OF THEIR SYNTHESIS AND USE<br/>[FR] MONOBACTAMES ET PROCÉDÉS DE SYNTHÈSE ET D'UTILISATION DE CES DERNIERS
  申请人：HARVARD COLLEGE

  公开号：WO2015103583A1

  公开（公告）日：2015-07-09

  Described herein are monobactam antibiotics of Formula (I), (Ι'), (II), and (II'), along with methods and intermediates for preparing these compounds. Pharmaceutical compositions and methods of treating infectious diseases using the monobactams are also provided.

  本文描述了单环内酰胺抗生素的化学式(I)、(Ι')、(II)和(II')，以及制备这些化合物的方法和中间体。还提供了使用单环内酰胺治疗传染病的药物组合物和方法。
• THERAPEUTIC AGENT FOR NON-MOTOR SYMPTOMS ASSOCIATED WITH PARKINSON'S DISEASE
  申请人：Sumitomo Dainippon Pharma Co., Ltd.

  公开号：EP3569233A1

  公开（公告）日：2019-11-20

  The purpose of the present invention is to provide: a therapeutic agent or a recurrence preventive agent for serotonergic system- or dopaminergic system-related diseases, in particular, mental dysfunction symptoms and other non-motor symptoms of Parkinson's disease; and a method for treating the aforesaid symptoms or preventing the recurrence of the same. A compound represented by formula (1) [wherein each symbol is as defined in the description] or a pharmaceutically acceptable salt thereof can exhibit an effect of treating serotonergic system- or dopaminergic system-related diseases, in particular, mental dysfunction symptoms and other non-motor symptoms of Parkinson's disease and/or an effect of preventing the recurrence of the same.

  本发明的目的是提供：一种治疗5-羟色胺能系统或多巴胺能系统相关疾病，特别是帕金森病的精神功能障碍症状和其他非运动症状的治疗剂或复发预防剂；以及一种治疗上述症状或预防上述症状复发的方法。由式(1)代表的化合物[其中各符号如描述中所定义]或其药学上可接受的盐可以显示出治疗血清素能系统或多巴胺能系统相关疾病的效果，特别是精神功能障碍症状和帕金森病的其他非运动症状，和/或防止其复发的效果。
• UYEHARA, TADAO;TAKAHASHI, MASAYUKI;KATO, TADAHIRO, TETRAHEDRON LETT., 1984, 25, N 36, 3999-4002
  作者：UYEHARA, TADAO、TAKAHASHI, MASAYUKI、KATO, TADAHIRO

  DOI：——

  日期：——
• MONOBACTAMS AND METHODS OF THEIR SYNTHESIS AND USE
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20160326157A1

  公开（公告）日：2016-11-10

  Described herein are monobactam antibiotics of Formula (I), (I′), (II), and (II′), along with methods and intermediates for preparing these compounds. Pharmaceutical compositions and methods of treating infectious diseases using the monobactams are also provided.