Chinazolin-4-on-2-yl-essigsaeureamid | 21417-20-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: Chinazolin-4-on-2-yl-essigsaeureamid
• 英文别名: 2-(4-Oxo-3,4-dihydro-2-quinazolinyl)acetamide；2-(4-oxo-3H-quinazolin-2-yl)acetamide
• CAS: 21417-20-9
• 化学式: C₁₀H₉N₃O₂
• mdl: MFCD05664568
• 分子量: 203.2
• InChiKey: HLGWEIMMQZUCMM-UHFFFAOYSA-N

物化性质

• 熔点：
  265-266 °C(Solv: N,N-dimethylformamide (68-12-2))
• 沸点：
  474.6±47.0 °C(Predicted)
• 密度：
  1.47±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  84.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  靛红酸酐 、 丙二酰脒盐酸盐 在 吡啶 作用下， 反应 5.0h， 以74%的产率得到Chinazolin-4-on-2-yl-essigsaeureamid
  参考文献：
  名称：

  Suesse, Manfred; Johne, Siegfried, Zeitschrift fur Chemie, 1983, vol. 23, # 11, p. 406 - 407

  摘要：

  DOI：

文献信息

• [EN] 1,4-DICARBONYL-PIPERIDYL DERIVATIVES<br/>[FR] DÉRIVÉS DE 1,4-DICARBONYLE-PIPÉRIDYLE
  申请人：MERCK PATENT GMBH

  公开号：WO2017076484A1

  公开（公告）日：2017-05-11

  Compounds of the formula I in which Z, W, Q, R and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

  式I中Z、W、Q、R和Y具有权利要求1中指示的含义的化合物是坦克酶的抑制剂，可用于治疗癌症、心血管疾病、中枢神经系统损伤和不同形式的炎症等疾病。
• DYEING COMPOSITION, DYED PRODUCT, AND AZO COLORING AGENT
  申请人：FUJIFILM Corporation

  公开号：US20200354576A1

  公开（公告）日：2020-11-12

  Provided are a dyeing composition which contains an azo coloring agent represented by Formula 1 or 2, a dyed product which is obtained by being dyed with the dyeing composition, and a novel azo coloring agent. In Formulae 1 and 2, C 1 represents a heteroaromatic group, A 1 and B 1 each independently represent a heteroaromatic group, an aromatic group, or a group having a methine structure, and at least one of A 1 or B 1 represents a heteroaromatic group, D 1 represents an anthraquinonyl group, and E 1 represents a heteroaromatic group, an aromatic group, or a group having a methine structure. A 1 -N═N—C 1 —N═N—B 1 Formula 1 D 1 -N═N-E 1 Formula 2

  提供了一种染料组合物，其中包含由式1或2表示的偶氮着色剂，用该染料组合物染色后获得的染色产品，以及一种新型偶氮着色剂。在式1和2中，C1代表杂芳族基，A1和B1各自独立地表示杂芳族基、芳香族基或具有亚甲基结构的基团，且A1或B1中至少一个代表杂芳族基，D1代表蒽醌基，E1代表杂芳族基、芳香族基或具有亚甲基结构的基团。A1-N═N—C1—N═N—B1（式1），D1-N═N-E1（式2）。
• Hair dye composition
  申请人：Kao Corporation

  公开号：EP1366752A1

  公开（公告）日：2003-12-03

  The present invention is directed to a hair dyeing composition comprising an azo dye of the following general formula (I)A - N = N - B    where A = monovalent, optionally substituted heterocyclic group binding via the carbon atom to the azo group, that does not contain carboxy (-CO2H) or sulfo groups (SO3H) or quaternary ammonium groups and B = heterocyclic, aromatic or alkyl group containing a dissociative proton and, which is free of carboxy (-CO2H) or sulfo groups (-SO3H) or quaternary ammonium groups. Additionally, the present invention describes a method of dyeing human or animal hair by using such a dye and the use of this direct azo dye for dyeing human or animal hair. The use of this direct azo dye can impart the hair with an extremely vivid colour and has a less colour fade over the time.

  本发明涉及一种染发组合物，包括以下通用式(I)A - N = N - B的偶氮染料，其中A = 通过碳原子与偶氮基结合的一价的、可选地取代的杂环基团，不含羧基（-CO2H）或磺酸基（SO3H）或季铵基团；B = 含有可解离质子的杂环、芳香或烷基团，且不含羧基（-CO2H）或磺酸基（-SO3H）或季铵基团。此外，本发明描述了一种通过使用这种染料来染色人类或动物头发的方法，以及使用这种直接偶氮染料来染色人类或动物头发。使用这种直接偶氮染料可以使头发呈现极为鲜艳的颜色，并且随着时间的推移，颜色褪色较少。
• Hair dye composition comprising an azo dye containing a dissociative proton, method and use
  申请人：Kao Corporation

  公开号：EP1398020A1

  公开（公告）日：2004-03-17

  The present invention is directed to a hair dyeing composition comprising a dissociative azo dye of the following general formula (I)         A-N=N-B     (1)    wherein A represents a phenyl or naphthyl group, wherein these groups may be substituted, wherein these phenyl or naphthyl groups do not contain sulfo or carboxyl groups or quaternary ammonium groups; and B represents an aromatic group required for the compound represented by the general formula (I) to form a dissociative azo dye which is free from anionic sulfo or carboxyl groups and quaternary ammonium groups. Additionally, the present invention describes a method of dyeing human or animal hair by using such a dye and the use of this direct azo dye for dyeing human or animal hair. The use of this direct azo dye can impart the hair with an extremely vivid color and has a less color fade over the time.

  本发明涉及一种染发组合物，该组合物包含以下通式 (I) 的离解型偶氮染料 A-N=N-B (1) 其中 A 代表苯基或萘基，这些基团可以被取代，其中这些苯基或萘基不含有硫基或羧基或季铵基；B 代表芳香基团，这些芳香基团是通式(I)所代表的化合物形成不含阴离子硫基或羧基及季铵基的离解型偶氮染料所必需的。此外，本发明还介绍了使用这种染料染人或动物毛发的方法，以及使用这种直接偶氮染料染人或动物毛发的方法。使用这种直接偶氮染料可以赋予头发极其鲜艳的颜色，并且随着时间的推移褪色较少。
• STAINING COMPOSITION, STAINED ARTICLE, AND AZO DYE
  申请人：FUJIFILM Corporation

  公开号：EP3747956A1

  公开（公告）日：2020-12-09

  Provided are a dyeing composition which contains an azo coloring agent represented by Formula 1 or 2, a dyed product which is obtained by being dyed with the dyeing composition, and a novel azo coloring agent. In Formulae 1 and 2, C1 represents a heteroaromatic group, A1 and B1 each independently represent a heteroaromatic group, an aromatic group, or a group having a methine structure, and at least one of A1 or B1 represents a heteroaromatic group, D1 represents an anthraquinonyl group, and E1 represents a heteroaromatic group, an aromatic group, or a group having a methine structure.         A1-N=N-C1-N=N-B1     Formula 1         D1-N=N-E1     Formula 2

  本发明提供了一种染色组合物，其中含有一种由式 1 或式 2 表示的偶氮染料；一种由该染色组合物染色得到的染色产品；以及一种新型偶氮染料。在式 1 和 2 中，C1 代表杂芳香族基团，A1 和 B1 各自独立地代表杂芳香族基团、芳香族基团或具有甲基结构的基团，A1 或 B1 中至少有一个代表杂芳香族基团，D1 代表蒽醌基团，E1 代表杂芳香族基团、芳香族基团或具有甲基结构的基团。 A1-N=N-C1-N=N-B1 分子式 1 D1-N=N-E1 分子式 2