RU 24476 | 65049-45-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: RU 24476
• 英文别名: 9α,11β-Dichloro-21-hydroxy-16α-methyl-pregna-1,4-diene-3,20-dione；Locicortolone；(8S,9R,10S,11S,13S,14S,16R,17S)-9,11-dichloro-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
• CAS: 65049-45-8
• 化学式: C₂₂H₂₈Cl₂O₃
• 分子量: 411.369
• InChiKey: FKRMBGXNTOTQDI-IIEHVVJPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(三甲基硅烷基)苯甲酰氯 、 RU 24476 生成 [2-[(8S,9R,10S,11S,13S,14S,16R)-9,11-dichloro-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl] 3-trimethylsilylbenzoate
  参考文献：
  名称：

  TEUTSCH, J. G.;DERAEDT, R.;BENZONI, J.

  摘要：

  DOI：

文献信息

• TEUTSCH, J. G.;DERAEDT, R.;BENZONI, J.
  作者：TEUTSCH, J. G.、DERAEDT, R.、BENZONI, J.

  DOI：——

  日期：——
• CYTOTOXIC NUCLEOSIDE-CORTICOSTEROID PHOSPHODIESTERS
  申请人：Research Corporation

  公开号：EP0033341A1

  公开（公告）日：1981-08-12
• US4283394A
  申请人：——

  公开号：US4283394A

  公开（公告）日：1981-08-11
• [EN] CYTOTOXIC NUCLEOSIDE-CORTICOSTEROID PHOSPHODIESTERS
  申请人：——

  公开号：WO1981000410A1

  公开（公告）日：1981-02-19

  (EN) Nucleotides of nucleosides or bases having known cytotoxic activity are reacted with steroids, preferably corticosteroids, to form corresponding cytotoxic nucleoside-corticosteroid phosphodiester analogues of the formula: (FORMULA) wherein: steroid is the residue formed by removal of a hydrocyl hydrogen atom from a natural or synthetic adrenal corticosteroid containing the characteristic cyclopentanophenanthrene nucleus which is esterified to the phosphate moiety at the 21-position; sugar is a naturally occuring pentose or deoxypentose in the furanose form, preferably ribose, deoxyribose, lyxose, xylose or arabinose and especially ribose, deoxyribose or arabinose, which is esterified to the phosphate moiety at the 5"-position and covalently bonded to the heterocycle moiety at the 1"-position to form a nucleoside; and heterocycle is a purine, pyrimidine, hydrogenated pyrimidine, triazolopurine or similar nucleoside base. The conjugates exhibit an enhanced therapeutic index as compared to the parent nucleoside or base compounds, and are thus useful cytotoxic, antiviral and antineoplastic agents. (FR) On fait reagir des nucleotides de nucleosides ou bases ayant une activite cytotoxique connue avec des steroides, de preference des corticosteroides, pour former des produits analogues aux phosphodiesters de nucleosides-corticosteroides cytotoxiques de formule: steroide-O-P-O-sucre-heterocycle (FORMULE) ou le steroide est le residu forme par extraction d"un atome d"hydrogene hydroxyle a partir d"un corticosteroide adrenal naturel ou synthetique contenant le noyau caracteristique cyclopentanophenanthrene qui est esterifie a la moitie de phosphate en position 21; le sucre est un pentose ou deoxypentose se produisant naturellement sous la forme de furanose, de preference ribose, desoxyribose, lyxose, xylose ou arabinose et specialement ribose, desoxyribose ou arabinose, qui est esterifie a la moitie de phosphate en position (5") et lie par covalence a la moitie de l"etherocycle en position (1") pour former un nucleoside; et l"heterocycle est une purine, pyrimidine, pyrimidine hydrogenee, triazolopurine ou base nucleoside similaire. Les conjugues ont un meilleur index therapeutique en comparaison des composes nucleosides ou bases de la meme famille, et sont donc utiles comme agents cytotoxiques, antiviraux et antineoplastes.