5-<1-(4-chlorophenyl)-2-phenylethyl>-2,4,6-trichloropyrimidine | 170955-72-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 5-<1-(4-chlorophenyl)-2-phenylethyl>-2,4,6-trichloropyrimidine
• 英文别名: 5-[1-(4-Chlorophenyl)-2-phenylethyl]-2,4,6-trichloropyrimidine；2,4,6-trichloro-5-[1-(4-chlorophenyl)-2-phenylethyl]pyrimidine
• CAS: 170955-72-3
• 化学式: C₁₈H₁₂Cl₄N₂
• 分子量: 398.119
• InChiKey: FZIDXCSMFNKDLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-<1-(4-chlorophenyl)-2-phenylethyl>-2,4,6-trichloropyrimidine 在 ammonium hydroxide 作用下， 以 乙醇 为溶剂， 反应 0.25h， 以84%的产率得到2-amino-5-<1-(4-chlorophenyl)-2-phenylethyl>-4,6-dichloropyrimidine
  参考文献：
  名称：

  Synthesis and antibacterial activity of 2-substituted 5-(1,2-diarylethyl)-4,6-dichloropyrimidine derivatives

  摘要：

  A series of 5-(1,2-diarylethyl)-2,4,6-trichloropyrimidines and 2-amino- and 2-(1-piperazinyl)-5-(1,2-diarylethyl)-4,6-dichloropyrimidines were synthesized via organozinc reagents. These new pyrimidine derivatives were tested against human bacterial flora. Biological tests showed that 5-[1-(4-chlorophenyl)-2-phenylethyl]-2,4,6-trichloropyrimidine is very active against a wide range of bacterial flora of the axilla and foot, while 2-amino and 2-(1-piperazinyl)-4,6- dichloropyrimidine derivatives display a great selectivity against Corynebacterium xerosis and Arcanobacterium haemolyticum of the human axilla.

  DOI：

  10.1016/0223-5234(96)88279-1
• 作为产物：
  描述：

  5-[(4-氯苯基)亚甲基]-1,3-二嗪农-2,4,6-三酮 在 盐酸 、 五氯化磷 、 三氯氧磷 作用下， 生成 5-<1-(4-chlorophenyl)-2-phenylethyl>-2,4,6-trichloropyrimidine
  参考文献：
  名称：

  Growth inhibition of Cryptococcus neoformans by 2-(1-piperazinyl)-5-(1,2-diarylethyl)-4,6-dichloropyrimidines: synthesis and in vitro studies

  摘要：

  2-(1-Piperazinyl)-5-[1-(4-chlorophenyl)-2-phenylethyl]-4,6-dichloropyrimidine and 2-(1-piperazinyl)-5-[1-(4-chlorophenyl)-2-(3-chlorophenyl)ethyl] -4,6-dichloropyrimidine were synthesized via organozinc reagents. These new pyrimidine derivatives were tested against human mycoflora. Biological tests showed that these compounds are selective growth inhibitors of Cryptococcus neoformans.

  DOI：

  10.1016/s0223-5234(96)80010-9

文献信息

• Synthesis and antibacterial activity of 2-substituted 5-(1,2-diarylethyl)-4,6-dichloropyrimidine derivatives
  作者：Y Fellahi、P Dubois、D Mandin、JE Ombetta-Goka、J Guenzet、JP Chaumont、Y Frangin

  DOI：10.1016/0223-5234(96)88279-1

  日期：1995.1

  A series of 5-(1,2-diarylethyl)-2,4,6-trichloropyrimidines and 2-amino- and 2-(1-piperazinyl)-5-(1,2-diarylethyl)-4,6-dichloropyrimidines were synthesized via organozinc reagents. These new pyrimidine derivatives were tested against human bacterial flora. Biological tests showed that 5-[1-(4-chlorophenyl)-2-phenylethyl]-2,4,6-trichloropyrimidine is very active against a wide range of bacterial flora of the axilla and foot, while 2-amino and 2-(1-piperazinyl)-4,6- dichloropyrimidine derivatives display a great selectivity against Corynebacterium xerosis and Arcanobacterium haemolyticum of the human axilla.
• Growth inhibition of Cryptococcus neoformans by 2-(1-piperazinyl)-5-(1,2-diarylethyl)-4,6-dichloropyrimidines: synthesis and in vitro studies
  作者：Y Fellah、D Mandin、P Dubois、JE Ombetta-Goka、J Guenzet、JP Chaumont、Y Frangin

  DOI：10.1016/s0223-5234(96)80010-9

  日期：1996.1

  2-(1-Piperazinyl)-5-[1-(4-chlorophenyl)-2-phenylethyl]-4,6-dichloropyrimidine and 2-(1-piperazinyl)-5-[1-(4-chlorophenyl)-2-(3-chlorophenyl)ethyl] -4,6-dichloropyrimidine were synthesized via organozinc reagents. These new pyrimidine derivatives were tested against human mycoflora. Biological tests showed that these compounds are selective growth inhibitors of Cryptococcus neoformans.