3--aminopropanol | 62237-10-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3--aminopropanol
• 英文别名: 3-{[3-(Dimethylamino)propyl](methyl)amino}propan-1-OL；3-[3-(dimethylamino)propyl-methylamino]propan-1-ol
• CAS: 62237-10-9
• 化学式: C₉H₂₂N₂O
• 分子量: 174.286
• InChiKey: YNRLEYANFPVBJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3--aminopropanol 、 碘甲烷 、 9H-氧杂蒽-9-甲酰氯 以40%的产率得到
  参考文献：
  名称：

  FELFOELDI K.; LASZLAVIK M.; BARTOK M.; KARPATI E., ACTA PHYS. ET CHEM. SZEGED, 1980, 26, NO 3-4, 163-169

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N-二甲基-3-氯丙胺 、 3-(甲胺基)-1-丙醇 以43%的产率得到
  参考文献：
  名称：

  FELFOELDI K.; LASZLAVIK M.; BARTOK M.; KARPATI E., ACTA PHYS. ET CHEM. SZEGED, 1980, 26, NO 3-4, 163-169

  摘要：

  DOI：

文献信息

• Sulfonamide compound
  申请人：Matsubara Koki

  公开号：US20090048223A1

  公开（公告）日：2009-02-19

  A compound represented by the formula (1) [A represents a nitrogen-containing saturated ring; m represents an integer of 0 to 2; n represents an integer of 1 to 4; G 1 represents hydrogen atom, chlorine atom, hydroxyl group, an alkoxy group, or amino group; G 2 represents a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, an amino group, an alkylsulfinyl group, an alkylsulfonyl group, or an aryl group; G 3 represents hydrogen atom, a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, an amino group, an alkoxycarbonyl group, an acyl group, an acyloxy group, an alkylsulfinyl group, an alkylsulfonyl group, or an aryl group; Y represents a single bond, or —C(R 3 )(R 4 )— (R 3 and R 4 represent hydrogen atom, or an alkyl group, or alkylene groups which combine together to form a saturated hydrocarbon ring group); G 4 represents hydroxyl group (Y is a single group), or —N(R 1 )(R 2 ) (R 1 and R 2 represent hydrogen atom, an alkyl group, an aralkyl group, an alkenyl group, an alkynyl group, a saturated heterocyclic group, an alkylsulfonyl group, an acyl group, or an amidino group); G 5 is a substituent on a ring-constituting carbon atom of A, and represents hydrogen atom, fluorine atom, or an alkyl group] or a salt thereof, or a derivative thereof that is a prodrug, which potently inhibits Rho kinase.

  由以下化学式表示的化合物：[A代表含氮饱和环；m表示0到2的整数；n表示1到4的整数；G1代表氢原子、氯原子、羟基、烷氧基或氨基；G2代表卤原子、羟基、氰基、羧基、烷基、烯基、炔基、烷氧基、烷硫基、氨基、烷氧羰基、酰基、乙酰氧基、烷基磺基、烷基磺酰基或芳基；G3代表氢原子、卤原子、羟基、氰基、羧基、烷基、烯基、炔基、烷氧基、烷硫基、氨基、烷氧羰基、酰基、乙酰氧基、烷基磺基、烷基磺酰基或芳基；Y代表单键，或-C(R3)(R4)-（R3和R4代表氢原子、烷基或烷烯基，它们结合在一起形成饱和碳氢环基）；G4代表羟基（Y是单个基），或-N(R1)(R2)（R1和R2代表氢原子、烷基、芳基、烯基、炔基、饱和杂环基、烷基磺酰基、酰基或胺基）；G5是A的环构成碳原子上的取代基，代表氢原子、氟原子或烷基]或其盐、或作为前药的衍生物，其强力抑制Rho激酶。
• Amide derivatives
  申请人：ASTRAZENECA AB

  公开号：US20030186966A1

  公开（公告）日：2003-10-02

  This invention concerns amide derivatives of Formula (I) wherein X is CH or N; Y is CH or N; m is 0-3; R 1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-3; R 2 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and (1-6C)alkoxycarbonyl; R 3 is hydrogen, halogeno, (1-6C)alkyl or (1-6C)alkoxy; q is 0-4; and Q is a group such as aryl, aryloxy, aryl-(1-6C)alkoxy, arylamino, N-(1-6C)alkyl-arylamino and aryl-(1-6C)alkylamino; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

  本发明涉及式（I）的酰胺衍生物，其中X为CH或N; Y为CH或N; m为0-3; R1为羟基、卤素、三氟甲基、氰基、巯基、硝基、氨基、羧基和氨基甲酰基等基团; n为0-3; R2为羟基、卤素、三氟甲基、氰基、巯基、硝基、氨基、羧基和(1-6C)烷氧基甲酰基等基团; R3为氢、卤素、(1-6C)烷基或(1-6C)烷氧基; q为0-4; Q为芳基、芳氧基、芳基-(1-6C)烷氧基、芳基氨基、N-(1-6C)烷基芳基氨基和芳基-(1-6C)烷基氨基等基团; 或其药学上可接受的盐或体内可降解的酯; 以及制备它们的方法、含有它们的制药组合物以及它们在通过细胞因子介导的疾病或医疗状况的治疗中的应用。
• N'-(2-Hydroxyalkyl)-N, N, N'-trimethyl-propylene diamines as catalysts
  申请人：Abbott Laboratories

  公开号：US04430455A1

  公开（公告）日：1984-02-07

  New ditertiary aminoalcohols are useful as catalysts in the preparation of polyurethane foams. The new catalysts are particularly stable in the presence of polyols and other components often used in the conjunction with such polyols.

  新的二级胺醇类化合物在聚氨酯泡沫的制备中作为催化剂具有重要作用。这些新的催化剂在聚醚醇和其他常与聚醚醇一起使用的组分的存在下尤其稳定。
• Benzamide derivatives for the treatment of diseases mediated by cytokines
  申请人：ASTRAZENECA AB

  公开号：US20030212068A1

  公开（公告）日：2003-11-13

  1 The invention concerns amide derivatives of Formula (I), wherein R 3 is (1-6C)alkyl or halogeno; m is 1-3 and R 1 is selected from substituents such as: (A) hydroxy, halogeno, (1-6C)alkyl, (1-6C)alkoxy, aryl, heteroaryl and heterocyclyl; and (B) di-[(1-6C)alkyl]amino-(1-6C)alkyl, (1-6C)alkoxy-(2-6C)alkoxy, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, aryloxy, heteroaryloxy, heteroaryl-(1-6C)alkoxy, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; p is 0-2 and R 2 is a substituent such as hydroxy and halogeno; q is 0-4; and R 4 is aryl or cycloalkyl which bears 1-3 substituents such as: (C) hydrogen, hydroxy, halogeno and heterocyclyl; and (D) heteroaryl-(1-6C)alkoxy and heterocyclyl-(1-6C)alkoxy, provided that a substituent on R 4 is selected from paragraph (C) only if at least one R 1 group is selected from paragraph (B); processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

  该发明涉及式(I)的酰胺衍生物，其中R3是(1-6C)烷基或卤素；m为1-3，R1被选择为以下取代基之一：(A)羟基、卤素、(1-6C)烷基、(1-6C)烷氧基、芳基、杂芳基和杂环基；和(B)二-[(1-6C)烷基]氨基-(1-6C)烷基、(1-6C)烷氧基-(2-6C)烷氧基、二-[(1-6C)烷基]氨基-(2-6C)烷氧基、芳氧基、杂芳氧基、杂芳基-(1-6C)烷氧基、杂环氧基和杂环基-(1-6C)烷氧基；p为0-2，R2是羟基和卤素等取代基；q为0-4；R4是芳基或环烷基，其带有1-3个取代基，例如：(C)氢、羟基、卤素和杂环基；和(D)杂芳基-(1-6C)烷氧基和杂环基-(1-6C)烷氧基，但仅当至少一个R1基团选择自段(B)时，才从段(C)中选择R4上的取代基；制备它们的方法，含有它们的制药组合物，以及它们在治疗由细胞因子介导的疾病或医疗状况中的应用。
• Substituted anilino-quinoline compounds and use thereof
  申请人：ASTRAZENECA AB

  公开号：US20030216417A1

  公开（公告）日：2003-11-20

  The invention concerns amide derivatives of Formula (I), wherein: G is N or CH; R 1 is a group such as hydroxy, halo, trifluoromethyl, C 1-6 alkyl and C 1-6 alkoxy; each of R 2 and R 3 is hydrogen, halo, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl; R 4 is a group such as hydrogen, hydroxy, C 1-6 alkyl, C 1-6 alkoxy and C 3-7 cycloalkyl, or R 4 is of the Formula (IC): —K-J, wherein J is aryl, heteroaryl or heterocyclyl and K is a bond or a group such as oxy and imino, R 5 is a group such as hydrogen, halo and trifluoromethyl; m is 1-3 and q is 0-4; or pharmaceutically acceptable salts or in vivo cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

  本发明涉及公式（I）的酰胺衍生物，其中：G为N或CH；R1为羟基、卤素、三氟甲基、C1-6烷基和C1-6烷氧基等基团；R2和R3中的每一个是氢、卤素、C1-6烷基、C2-6烯基或C2-6炔基；R4为氢、羟基、C1-6烷基、C1-6烷氧基和C3-7环烷基等基团，或者R4为公式（IC）中的基团：—K-J，其中J为芳基、杂芳基或杂环基，K为键或氧和亚胺等基团；R5为氢、卤素和三氟甲基等基团；m为1-3，q为0-4；或其药学上可接受的盐或体内可水解的酯。本发明还涉及制备这些化合物的方法、含有它们的制药组合物以及它们在治疗由细胞因子介导的疾病或医疗情况中的用途。