2-tert-Butyl-2H-thiopyran | 68883-87-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫吡喃类
• 英文名称: 2-tert-Butyl-2H-thiopyran
• CAS: 68883-87-4
• 化学式: C₉H₁₄S
• 分子量: 154.27
• InChiKey: LSJPQAWUIFNKJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-H-Thiopyran 、 溴代叔丁烷 、 氨 以54%的产率得到
  参考文献：
  名称：

  GRAEFING R.; VERKRUIJSSE H. D.; BRANDSMA L., J. CHEM. SOC. CHEM. COMMUN., 1978, NO 14, 596-597

  摘要：

  DOI：

文献信息

• Orally Bioavailable Caffeic Acid Related Anticancer Drugs
  申请人：Priebe Waldemar

  公开号：US20070232668A1

  公开（公告）日：2007-10-04

  The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2/STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines.

  本发明涉及化合物及其用于治疗细胞增殖性疾病如癌症的用途。本发明的化合物作为Jak2/STAT3途径和下游靶点的抑制剂显示出显著的效力，并抑制癌细胞系的生长和存活。
• Novel Inhibitors of Proliferation and Activation of Signal Transducer and Activator of Transcription (STATS)
  申请人：Priebe Waldemar

  公开号：US20110053992A1

  公开（公告）日：2011-03-03

  Pyridine compounds effective in modulation STAT3 and/or STAT5 activation are provided that are useful in the prevention and treatment of proliferative disease and conditions including cancer, inflammation and proliferative skin disorders.

  提供有效调节STAT3和/或STAT5激活的吡啶化合物，可用于预防和治疗增生性疾病和病症，包括癌症、炎症和增生性皮肤疾病。
• NOVEL INHIBITORS OF PROLIFERATION AND ACTIVATION OF SIGNAL TRANSDUCER AND ACTIVATORS OF TRANSCRIPTION (STATS)
  申请人：Priebe Waldemar

  公开号：US20120149738A1

  公开（公告）日：2012-06-14

  Pyridine compounds effective in modulation STAT3 and/or STAT5 activation are provided that are useful in the prevention and treatment of proliferative disease and conditions including cancer, inflammation and proliferative skin disorders.

  提供了能够有效调节STAT3和/或STAT5激活的吡啶化合物，可用于预防和治疗增生性疾病和病症，包括癌症、炎症和增生性皮肤疾病。
• NOVEL INHIBITORS OF PROLIFERATION AND ACTIVATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STATS)
  申请人：Board of Regents, The University of Texas System

  公开号：US20140228414A1

  公开（公告）日：2014-08-14

  Pyridine compounds effective in modulation STAT3 and/or STAT5 activation are provided that are useful in the prevention and treatment of proliferative disease and conditions including cancer, inflammation and proliferative skin disorders.

  提供了在调节STAT3和/或STAT5激活方面有效的吡啶化合物，这些化合物在预防和治疗增生性疾病和病症中包括癌症、炎症和增生性皮肤疾病方面具有用处。
• ORALLY BIOAVAILABLE CAFFEIC ACID RELATED ANTICANCER DRUGS
  申请人：The Board of Regents of the University of Texas System

  公开号：US20150094343A1

  公开（公告）日：2015-04-02

  The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2/STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines.

  本发明涉及化合物及其用于治疗细胞增殖性疾病，例如癌症。本发明的化合物作为Jak2 / STAT3途径及下游靶点的抑制剂具有显著的效力，并抑制癌细胞系的生长和存活。