methyl dibenzo[b,d]furan-4-carboxylate | 92151-89-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: methyl dibenzo[b,d]furan-4-carboxylate
• 英文别名: Methyl dibenzofuran-4-carboxylate；dibenzofuran-4-carboxylic acid methyl ester；Dibenzofuran-4-carbonsaeure-methylester
• CAS: 92151-89-8
• 化学式: C₁₄H₁₀O₃
• 分子量: 226.232
• InChiKey: ZBKHXDCUAQMZNR-UHFFFAOYSA-N

物化性质

• 熔点：
  142-144 °C
• 沸点：
  361.4±15.0 °C(Predicted)
• 密度：
  1.268±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl dibenzo[b,d]furan-4-carboxylate 在 喹啉 、 盐酸 、 硝酸 、 铜 、 溶剂黄146 作用下， 生成 3-硝基双苯并呋喃
  参考文献：
  名称：

  Dibenzofuran. VIII. Heteronuclear Substitution

  摘要：

  DOI：

  10.1021/ja01872a030
• 作为产物：
  描述：

  methyl 3-nitro-2-phenoxybenzoate 在 potassium phosphate 、 2-(二环己基膦)3,6-二甲氧基-2′,4′,6′-三异丙基-1,1′-联苯 、 palladium(II) acetylacetonate 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以96%的产率得到methyl dibenzo[b,d]furan-4-carboxylate
  参考文献：
  名称：

  Pd催化反式分子内CH芳基化

  摘要：

  已经开发了钯催化的硝基芳烃的分子内C–H芳基化反应。硝基芳烃轴承拴系的芳基在邻位-位可以在从2-halonitroarenes一个步骤通过亲核芳族取代（S容易地制备Ñ AR）。在Pd / BrettPhos催化下，芳烃上C–NO 2键以及C–H键的活化产生了相应的联芳基键合，产率中等至极佳。

  DOI：

  10.1021/acs.orglett.9b01593

文献信息

• Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents
  作者：N. Lakshminarayana、Y. Rajendra Prasad、Laxmikant Gharat、Abraham Thomas、Shridhar Narayanan、A. Raghuram、C.V. Srinivasan、Balasubramanian Gopalan

  DOI：10.1016/j.ejmech.2010.05.020

  日期：2010.9

  A series of novel dibenzo[b,d]furan mono-carboxylic acid derivatives were synthesized, characterized and evaluated for their ability to inhibit Protein Tyrosine Phosphatase 1B (PTP1B) in vitro in order to use them as potential anti-diabetic agents. Structure–activity relationship study led to the identification of potent compound 5E which inhibited PTP1B with IC50 value of 82 ± 0.43 nM. Compound 5E

  合成，表征和评估了一系列新颖的二苯并[ b，d ]呋喃单羧酸衍生物，以在体外抑制蛋白酪氨酸磷酸酶1B（PTP1B）的能力，以便将其用作潜在的抗糖尿病药。结构-活性关系研究导致鉴定出有效化合物5E，该化合物抑制PTP1B，IC 50值为82±0.43 nM。使用马来酸罗格列酮作为标准品，在体内筛选化合物5E作为抗糖尿病活性的候选药物。化合物5E结果显示，ob / ob小鼠的体重，摄食状态全血糖（WBG），禁食WBG，血浆葡萄糖和血浆胆固醇水平显着降低，而禁食血浆甘油三酸酯水平无明显降低。
• [EN] NOVEL DIBENZOFURANYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE<br/>[FR] NOUVEAUX DÉRIVÉS DE DIBENZOFURANYL-OXADIAZOLYL-DIAZABICYCLONONANE, ET UTILISATION MÉDICALE DE CEUX-CI
  申请人：NEUROSEARCH AS

  公开号：WO2010086279A1

  公开（公告）日：2010-08-05

  This invention relates to novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  这项发明涉及新型的二苯并呋喃基-噁二唑基-二氮杂双环壬烷衍生物及其在制备药物组合物中的应用。该发明的化合物被发现是胆碱能受体的胆碱能配体，同时也是单胺受体和转运体的调节剂。由于它们的药理特性，该发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩、内分泌疾病、神经退行性疾病、炎症、疼痛以及由于滥用化学物质终止而引起的戒断症状等各种疾病或紊乱具有用处。
• NOVEL DIBENZOFURANYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE
  申请人：Peters Dan

  公开号：US20120028968A1

  公开（公告）日：2012-02-02

  This invention relates to novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型的二苯并呋喃基-噁唑啉基-二氮杂双环壬烷衍生物及其在制造药物组合物方面的应用。本发明的化合物被发现是乙酰胆碱受体的胆碱能配体和单胺受体及转运体的调节剂。由于它们的药理特性，本发明的化合物对于治疗与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统相关的疾病或疾病，与平滑肌收缩有关的疾病或疾病，内分泌疾病或疾病，与神经退行性有关的疾病或疾病，与炎症、疼痛和由于化学物质滥用终止而引起的戒断症状等多种疾病或疾病可能有用。
• Dibenzofuran. XIII. Orientation and Substituted Amines
  作者：Henry. Gilman、Paul T. Parker、James C. Bailie、George E. Brown

  DOI：10.1021/ja01265a080

  日期：1939.10.1
• Culture wars in the classroom: Prospective teachers question science
  作者：Karen Sullenger、Steve Turner、Hart Caplan、Joe Crummey、Rick Cuming、Cynthia Charron、Beth Corey

  DOI：10.1002/1098-2736(200011)37:9<895::aid-tea3>3.0.co;2-3

  日期：2000.11

  Does studying about the nature(s) of science contribute to a prospective teachers' effectiveness as a science teacher? This research grew out of a course created by a science educator and historian of science who believed prospective teachers needed more complex understandings of the cultural wars surrounding science. The research team consisted of five prospective teachers who participated in the course as well as the two instructors. This paper describes the experience of participating in the course from both perspectives. We argue that studying the cultural wars over science contributes to prospective teachers' professional growth as much because the course elicits tacit beliefs about school science as it introduces more complex understandings of science. We found that prospective teachers' tacit beliefs about school science were their greatest barrier to developing more complex understandings about the nature(s) of science. We contend that willingness to grapple with complexity and developing a professional identity by locating oneself in the conversations about the nature(s) of science are better criteria for determining the professional growth of prospective teachers than knowledge measures. Finally, we argue that prospective teachers should be viewed as professionals who are responsible for finding their own voice, making their own decisions, and considering the consequences of their beliefs on their practice. This study raises questions critical to teacher education programs for prospective teachers and teacher-educators alike. (C) 2000 John Wiley & Sons, Inc.