(4-(2-chlorophenyl)piperazin-1-yl)(2-(4-methoxyphenyl)-4-vinyl-2,5-dihydrofuran-3-yl)methanone | 1358032-49-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (4-(2-chlorophenyl)piperazin-1-yl)(2-(4-methoxyphenyl)-4-vinyl-2,5-dihydrofuran-3-yl)methanone
• 英文别名: [4-(2-Chlorophenyl)piperazin-1-yl]-[4-ethenyl-2-(4-methoxyphenyl)-2,5-dihydrofuran-3-yl]methanone
• CAS: 1358032-49-1
• 化学式: C₂₄H₂₅ClN₂O₃
• 分子量: 424.927
• InChiKey: OGACMBPLTAURAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  42
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲氧基亚苄基丙二酸二乙酯 在 氯化亚砜 、 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 26.08h， 生成 (4-(2-chlorophenyl)piperazin-1-yl)(2-(4-methoxyphenyl)-4-vinyl-2,5-dihydrofuran-3-yl)methanone
  参考文献：
  名称：

  Synthesis of novel 2, 5-dihydrofuran derivatives and evaluation of their anticancer activity

  摘要：

  According to metal-catalyzed [3 + 2] cycloaddition reaction, we synthesized a series of novel 2, 5-dihydrofuran derivatives and evaluated their in vitro anti-cancer activities via MTT method. The bioassay showed that the majority of the resultant compounds exerted anti-tumor effect against four human cancer cell lines to various extents, which supported the rationale of the design. Compounds 9e and 10g showed the highest activity with broad anti-cancer spectrum, which were good candidates for further evaluation. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.11.036

文献信息

• Synthesis of novel 2, 5-dihydrofuran derivatives and evaluation of their anticancer activity
  作者：Yikai Zhang、Hanyu Zhong、Tiantian Wang、Dongping Geng、Mingfeng Zhang、Ke Li

  DOI：10.1016/j.ejmech.2011.11.036

  日期：2012.2

  According to metal-catalyzed [3 + 2] cycloaddition reaction, we synthesized a series of novel 2, 5-dihydrofuran derivatives and evaluated their in vitro anti-cancer activities via MTT method. The bioassay showed that the majority of the resultant compounds exerted anti-tumor effect against four human cancer cell lines to various extents, which supported the rationale of the design. Compounds 9e and 10g showed the highest activity with broad anti-cancer spectrum, which were good candidates for further evaluation. (C) 2011 Elsevier Masson SAS. All rights reserved.