1,4-Butanediamine, N-[3-(methylamino)propyl]- | 163405-02-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,4-Butanediamine, N-[3-(methylamino)propyl]-
• 英文别名: N'-[3-(methylamino)propyl]butane-1,4-diamine
• CAS: 163405-02-5
• 化学式: C₈H₂₁N₃
• 分子量: 159.27
• InChiKey: MPOZXEVERBOKDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.1
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] PHARMACEUTICAL OR COSMETIC COMPOSITION FOR TREATING ALOPECIA<br/>[FR] COMPOSITION PHARMACEUTIQUE OU COSMÉTIQUE DESTINÉE AU TRAITEMENT DE L'ALOPÉCIE
  申请人：GIULIANI SPA

  公开号：WO2014016407A1

  公开（公告）日：2014-01-30

  The present invention relates to a cosmetic or pharmaceutical composition for treating alopecia, and in general for counteracting excessive hair loss, comprising as an active ingredient a compound of formula (I) R-N1-spermidine, or 1,4-butanediamine,N-(3-aminopropyl)-N1-R. The compounds of general formula (I) are active in accordance with the objects of the present invention, and also sufficiently stable to allow effective application for topical use on the scalp without potentially being transformed into a different substance, which is no longer active, as a result of oxidation.

  本发明涉及一种用于治疗脱发，通常用于对抗过度脱发的化妆品或药用组合物，其活性成分为化合物R-N1-精胺，或1,4-丁二胺，N-(3-氨丙基)-N1-R的化合物。根据本发明的目的，通用式(I)的化合物是活性的，同时也足够稳定，可以有效地应用于头皮表面，而不会因为氧化而转化为不再活性的不同物质。
• PHARMACEUTICAL OR COSMETIC COMPOSITION FOR TREATING ALOPECIA
  申请人：GIULIANI S.P.A.

  公开号：US20150202132A1

  公开（公告）日：2015-07-23

  The present invention relates to a cosmetic or pharmaceutical composition for treating alopecia, and in general for counteracting excessive hair loss, comprising as an active ingredient a compound of formula (I) R—N 1 -spermidine, or 1,4-butane-diamine,N-(3-aminopropyl)-N 1 —R. The compounds of general formula (I) are active in accordance with the objects of the present invention, and also sufficiently stable to allow effective application for topical use on the scalp without potentially being transformed into a different substance, which is no longer active, as a result of oxidation.

  本发明涉及一种用于治疗脱发的化妆品或药用组合物，一般用于对抗过度脱发，包括作为活性成分的化合物，其化学式为(I) R—N1-精胺，或1,4-丁二胺，N-(3-氨基丙基)-N1-R。根据本发明的目的，一般式(I)的化合物是活性的，同时也足够稳定，可以在头皮上有效应用于局部使用，而不会由于氧化而可能转化为不再活性的不同物质。
• [EN] SURFACE TREATMENTS<br/>[FR] TRAITEMENTS DE SURFACE
  申请人：BOVIN NICOLAI VLADIMIROVICH

  公开号：WO2016185331A1

  公开（公告）日：2016-11-24

  Methods of treating surfaces to provide an antibacterial surface or a surface to which micro-dimensioned particles will adhere are disclosed. Water dispersible selenide-lipid and polycation-lipid constructs for use in the methods are also disclosed.

  公开了用于提供抗菌表面或微维粒子附着表面的处理表面的方法。还公开了用于这些方法的可水分散的硒脂和阳离子脂质构建物。
• [EN] MODULARLY ASSEMBLED SMALL MOLECULES FOR THE TREATMENT OF MYOTONIC DYSTROPHY TYPE 1<br/>[FR] PETITES MOLÉCULES ASSEMBLÉES DE MANIÈRE MODULAIRE POUR LE TRAITEMENT DE LA DYSTROPHIE MYOTONIQUE DE TYPE 1
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2015031819A1

  公开（公告）日：2015-03-05

  To study RNA function using small molecules, we designed bioactive, modularly assembled small molecules that target the noncoding expanded RNA repeat that causes myotonic dystrophy type 1 (Dml), r(CUG)exp. Different modular assembly scaffolds were investigated including polyamines, alpha-peptides, beta-peptides, and peptide tertiary amides (PT As). Based on activity as assessed by improvement of DM1 -associated defects, stability against proteases, cellular permeability, and toxicity, we discovered that constrained backbones, namely PT As, are optimal.

  为了研究使用小分子来研究RNA功能，我们设计了具有生物活性的模块化组装的小分子，以靶向导致肌无力型肌萎缩症1型（Dml）的非编码扩展RNA重复物质r(CUG)exp。我们研究了不同的模块化组装支架，包括聚胺、α-肽、β-肽和肽三级酰胺（PTAs）。根据通过改善DM1相关缺陷评估的活性、对蛋白酶的稳定性、细胞渗透性和毒性，我们发现受限的骨架，即PTAs，是最佳选择。
• AMIDE DERIVATIVES OF SQUALAMINE FOR THE TREATMENT OF INFECTIONS
  申请人：VIRBAC

  公开号：US20190262362A1

  公开（公告）日：2019-08-29

  A compound of formula (I) in which R′ represents a group —(CR a R b ) n —X—(CR c R d ) m —[Y—(CR e R f ) o ] t —NR 9 R 10 and X and Y independently represent a group —NR11-, a group —O— or a divalent 5-membered or 6-membered heterocyclic group comprising at least one nitrogen atom, and also the stereoisomers, mixtures of stereoisomers, and/or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical or veterinary compositions containing the compound of formula (I) and also to the use thereof as medicament, more particularly in the treatment of bacterial, fungal, viral or parasitic infections. Also further disclosed are pharmaceutical or veterinary compositions including the compound of formula (I) in combination with an antibiotic other than such a compound of formula (I).

  化合物的公式(I)，其中R′代表一个基团- (CRaRb)n-X-(CRcRd)m-[Y-(CReRf)o]t-NR9R10，X和Y分别代表一个基团-NR11-，一个基团-O-或者至少包含一个氮原子的二价五元或六元杂环基团，以及其立体异构体、立体异构体混合物和/或药学上可接受的盐。还公开了包含公式(I)化合物的制药或兽医组合物，以及在治疗细菌、真菌、病毒或寄生虫感染方面作为药物的用途。还公开了包含公式(I)化合物和除公式(I)化合物以外的抗生素的制药或兽医组合物。