4-(3-bromophenyl)tetralen-2-ol phenylacetate | 1187323-12-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(3-bromophenyl)tetralen-2-ol phenylacetate
• 英文别名: [4-(3-Bromophenyl)-3,4-dihydronaphthalen-2-yl] 2-phenylacetate
• CAS: 1187323-12-1
• 化学式: C₂₄H₁₉BrO₂
• 分子量: 419.318
• InChiKey: UJFSZFXJYBPCTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(3-bromophenyl)tetralen-2-ol phenylacetate 、 苯硼酸 在 potassium phosphate 、 palladium diacetate 、 2-(二环己基膦基)联苯 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以70%的产率得到4-(biphenyl-3-yl)tetralen-2-ol phenylacetate
  参考文献：
  名称：

  New approach to 4-phenyl-β-aminotetralin from 4-(3-halophenyl)tetralen-2-ol phenylacetate

  摘要：

  Mixed trifluoroacetyl phenylacetyl anhydride and 3-halostyrenes (fluoro, chloro, and bromo) or vinylcycloalkanes (cyclohexyl and cyclooctyl), undergo cascade Friedel-Crafts cycli-acylalkylation. enolization, and O-acylation to give 4-substituted tetralen-2-ol phenylacetates, Without additional solvent in good yields. Base alcoholysis of 4-phenyltetralen-2-ol phenyl acetate reveals the tetral-2-one for asymmetric transfer hydrogenation. Bromophenyltetralen-2-ol phenylacetate undergoes Suzuki coupling, and provides a short route to trans-4-phenyl-beta-aminotetralin. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.099
• 作为产物：
  描述：

  苯乙酸 、 3-溴苯乙烯 在 三氟乙酸酐 作用下， 反应 24.08h， 以50%的产率得到4-(3-bromophenyl)tetralen-2-ol phenylacetate
  参考文献：
  名称：

  New approach to 4-phenyl-β-aminotetralin from 4-(3-halophenyl)tetralen-2-ol phenylacetate

  摘要：

  Mixed trifluoroacetyl phenylacetyl anhydride and 3-halostyrenes (fluoro, chloro, and bromo) or vinylcycloalkanes (cyclohexyl and cyclooctyl), undergo cascade Friedel-Crafts cycli-acylalkylation. enolization, and O-acylation to give 4-substituted tetralen-2-ol phenylacetates, Without additional solvent in good yields. Base alcoholysis of 4-phenyltetralen-2-ol phenyl acetate reveals the tetral-2-one for asymmetric transfer hydrogenation. Bromophenyltetralen-2-ol phenylacetate undergoes Suzuki coupling, and provides a short route to trans-4-phenyl-beta-aminotetralin. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.099

文献信息

• THERAPEUTIC COMPOUNDS
  申请人：Booth Raymond G.

  公开号：US20120149693A1

  公开（公告）日：2012-06-14

  The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C and/or RSK disorders, including diseases and disorders mediated by GPCRs and/or RSKs.

  本发明涉及蛋白质结合相互作用/结合化合物及其鉴定和使用方法。本发明还涉及制药组合物和治疗5-HT2C和/或RSK障碍的方法，包括由GPCR和/或RSK介导的疾病和障碍。
• Therapeutic tetrahydronaphthalene compounds
  申请人：University of Florida Research Foundation, Inc.

  公开号：US10017458B2

  公开（公告）日：2018-07-10

  The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C and/or RSK disorders, including diseases and disorders mediated by CPCRs and/or RSKs.

  本发明涉及蛋白结合相互作用/结合化合物及其鉴定和使用方法。本发明还涉及治疗 5-HT2C 和/或 RSK 疾病（包括由 CPCR 和/或 RSK 介导的疾病和失调）的药物组合物和方法。
• US9024071B2
  申请人：——

  公开号：US9024071B2

  公开（公告）日：2015-05-05
• [EN] THERAPEUTIC COMPOUNDS<br/>[FR] COMPOSÉS THÉRAPEUTIQUES
  申请人：UNIV FLORIDA

  公开号：WO2010129048A2

  公开（公告）日：2010-11-11

  The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C and/or RSK disorders, including diseases and disorders mediated by GPCRs and/or RSKs.
• New approach to 4-phenyl-β-aminotetralin from 4-(3-halophenyl)tetralen-2-ol phenylacetate
  作者：Adam S. Vincek、Raymond G. Booth

  DOI：10.1016/j.tetlet.2009.06.099

  日期：2009.9

  Mixed trifluoroacetyl phenylacetyl anhydride and 3-halostyrenes (fluoro, chloro, and bromo) or vinylcycloalkanes (cyclohexyl and cyclooctyl), undergo cascade Friedel-Crafts cycli-acylalkylation. enolization, and O-acylation to give 4-substituted tetralen-2-ol phenylacetates, Without additional solvent in good yields. Base alcoholysis of 4-phenyltetralen-2-ol phenyl acetate reveals the tetral-2-one for asymmetric transfer hydrogenation. Bromophenyltetralen-2-ol phenylacetate undergoes Suzuki coupling, and provides a short route to trans-4-phenyl-beta-aminotetralin. (C) 2009 Elsevier Ltd. All rights reserved.