甲基-亚胂二碘化物 | 7207-97-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 中文名称: 甲基-亚胂二碘化物
• 中文别名: 甲基二碘胂
• 英文名称: methyldiiodoarsine
• 英文别名: Diiod-methyl-arsin；diiodo(methyl)arsine；diiodo(methyl)arsane
• CAS: 7207-97-8
• 化学式: CH₃AsI₂
• 分子量: 343.765
• InChiKey: ZKGSUVMABCXPKK-UHFFFAOYSA-N

物化性质

• 熔点：
  28°C
• 沸点：
  80.5°C
• 溶解度：
  可溶于氯仿（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  1.94
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  甲基-亚胂二碘化物 在 碘 作用下， 生成 甲基胂酸
  参考文献：
  名称：

  Bougault, Chemisches Zentralblatt, 1907, p. II,1359

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基胂酸 在 盐酸 、 二氧化硫 、 potassium iodide 作用下， 以 水 为溶剂， 反应 4.0h， 以56%的产率得到甲基-亚胂二碘化物
  参考文献：
  名称：

  Comparative Inhibition of Yeast Glutathione Reductase by Arsenicals and Arsenothiols

  摘要：

  Tri(gamma-glutamylcysteinylglycinyl)trithioarsenite (As-III(GS)(3)) is formed in cells and is a more potent mixed-type inhibitor of the reduction of glutathione disulfide (GSSG) by yeast glutathione (GSH) reductase than either arsenite (As-III) or GSH. The present work examines the effects of valence and complexation of arsenicals with GSH or L-cysteine (Cys) upon potency as competitive inhibitors of the reduction of GSH disulfide (GSSG) by yeast GSH reductase. Trivalent arsenicals were more potent inhibitors than their pentavalent analogs, and methylated trivalent arsenicals were more potent inhibitors than was inorganic trivalent As. Complexation of either inorganic trivalent As or methylarsonous diiodide ((CH3AsI2)-I-III) with Cys or GSH produced inhibitors of GSH reductase that were severalfold more potent than the parent arsenicals. In contrast, dimethylarsinous iodide ((CH3)(2)(AsI)-I-III) was a more potent inhibitor than its complexes with either GSH or Cys. Complexes of CH3AsIII with GSH (CH3AsIII(GS)(2)) or with Cys (CH3AsIII(Cys)(2)) were the most potent inhibitors, with K-i's of 0.009 and 0.018 mM, respectively. Inhibition of GSH reductase by arsenicals or arsenothiols was prevented by addition of meso-2,3-dimercaptosuccinic acid (DMSA) to a mixture of enzyme, GSSG, and inhibitor before addition of NADPH. DMSA added to the reaction mixture after NADPH reversed inhibition by (CH3)(2)(AsI)-I-III but had little effect on inhibition by (CH3AsI2)-I-III, CH3AsIII(GS)(2), CH3AsIII(Cys)(2), Or AS(III)(GS)(3). Partial redox inactivation of the enzyme with NADPH increased the inhibitory potency of (CH3AsI2)-I-III and (CH3)(2)(AsI)-I-III and changed the mode of inhibition for (CH3AsI2)-I-III from competitive to noncompetitive. The greater potency of methylated trivalent arsenicals and arsenothiols than of inorganic trivalent As suggests that biomethylation of As could yield species that inhibit reduction of GSSG and alter the redox status of cells.

  DOI：

  10.1021/tx960139g
• 作为试剂：
  描述：

  己基溴化镁 在 乙醚 、 甲基-亚胂二碘化物 作用下， 生成 十二烷
  参考文献：
  名称：

  Jones et al., Journal of the Chemical Society, 1932, p. 2284,2289

  摘要：

  DOI：

文献信息

• PERFLUOROALKYL ARSENICALS: PART IV. SOME REACTIONS OF TRIFLUOROIODOMETHANE WITH ALKYL ARSINES
  作者：W. R. Cullen

  DOI：10.1139/v62-067

  日期：1962.3.1

  trimethylarsine. Trifluoroiodomethane also reacts with the compounds (CH3)2AsX (X = C6H5, Cl, I) and CH3AsI2 to give CH3As(CF3)2; and in most of these reactions the compound CH3As(CF3)I is also formed, which is converted to the compound CH3As(CF3)Cl by reaction with silver chloride.

  三氟碘甲烷与三乙基和三正丁基胂以及三正丁基膦反应生成 R2MCF3 型产物。七氟碘丙烷与三甲基胂的反应类似。三氟碘甲烷还与化合物 (CH3)2AsX (X = C6H5, Cl, I) 和 CH3AsI2 反应生成 CH3As(CF3)2；在大多数这些反应中，还会形成化合物 CH3As(CF3)I，通过与氯化银反应将其转化为化合物 CH3As(CF3)Cl。
• In-situ Iodination of Organoarsenic Homocycles: Facile Synthesis of 9-Arsafluorene
  作者：Takuji Kato、Susumu Tanaka、Kensuke Naka

  DOI：10.1246/cl.150657

  日期：2015.11.5

  We developed an in-situ iodination of organoarsenic homocycles for facile and general As–C bond formation. Quantitative in-situ generations of arsenic diiodides from organoarsenic homocycles and iodine were confirmed by 1H NMR analysis. 9-Phenyl- and 9-methyl-9-arsafluorenes were prepared by this method and their optical properties were studied.

  我们开发了一种原位碘化有机砷同环化合物的简便且通用的As–C键形成方法。通过1H核磁共振（NMR）分析确认了从有机砷同环化合物和碘原位定量生成的二碘化砷。通过这种方法制备了9-苯基-9-砷杂芴和9-甲基-9-砷杂芴，并研究了它们的光学性质。
• Die komplexchemie polyfunktioneller liganden
  作者：Jochen Ellermann、Horst Schössner、Armin Haag、Hanns Schödel

  DOI：10.1016/s0022-328x(00)83884-x

  日期：1974.1

  The phenylalkyl arsines (CH3)2AsC6H5, CH3As(C6H5)2, C2H5As(C6H5)2, (CH2)n [As(C6H5)2]2 (n = 1, 2), and C[CH2As(C6H5)2]4 react with liquid or gaseous HI in nonaqueous solvents by selective cleavage of the arsenicphenyl bonds yielding (CH3)2AsI, CH3AsI2, C2H5AsI2, (CH2)n(AsI2)2 and C(CH2AsI2)4. The latter forms the tetradentate ligand C[CH2As(CH3)2]4 with CH3MgI. The electron impact mass spectra of

  苯基烷基a（CH 3）2 AsC 6 H 5，CH 3 As（C 6 H 5）2，C 2 H 5 As（C 6 H 5）2，（CH 2）n [As（C 6 H 5）2 ] 2（n = 1，2）和C [CH 2 As（C 6 H 5）2 ] 4通过选择性裂解砷苯基键，与液态或气态HI在非水溶剂中反应，生成（CH 3）2 AsI，CH 3 AsI 2，C 2 H 5 AsI 2，（CH 2）n（AsI 2）2和C （CH 2 AsI 2）4。后者与CH 3形成四齿配体C [CH 2 As（CH 3）2 ] 4MgI。这些化合物的电子冲击质谱图显示出清晰的碎片图谱，主要是由于形成具有AsAs键或（As）n团簇（n = 3，4 ）的碎片而引起的。由CH 3 AsI 2和C 2 H 5 AsI 2组成的无碘环砷化物（AsCH 3）3，（AsC 2 H 5）3，（AsC 2 H 5）4，As 3（C
• Dibenzoarsepins: Planarization of 8π‐Electron System in the Lowest Singlet Excited State
  作者：Ikuo Kawashima、Hiroaki Imoto、Masatoshi Ishida、Hiroyuki Furuta、Shunsuke Yamamoto、Masaya Mitsuishi、Susumu Tanaka、Toshiki Fujii、Kensuke Naka

  DOI：10.1002/anie.201904882

  日期：2019.8.19

  dual photoluminescence in the green‐to‐red region (500–700 nm) and the near‐ultraviolet region (<380 nm), which could be attributed to the planarization of the arsepin core in the lowest singlet excited (S1) state. The computational approach for the assessment of the aromatic indices revealed that the dibenzoarsepins studied show aromaticity (8π system) in the S1 states in line with Baird's rule. The

  合成了与其他异源销相比，具有严重扭曲的核的二苯并[b，f] arsepin。这些衍生物在绿色至红色区域（500-700 nm）和近紫外线区域（<380 nm）具有双重光致发光，这可能归因于在最低的单线态激发下，arsepin核心的平面化（S 1） 状态。评估芳香指数的计算方法表明，所研究的二苯并arsepins在S 1态下显示出芳香性（8π体系），符合贝尔德法则。砷原子的孤对电子在S 1态的芳香性中起着至关重要的作用。
• Reactions of alkylphosphorus, arsenic, and antimony hydrides and halides with dibenzylmercury. An improved procedure for cyclopolyarsines
  作者：Arnold L. Rheingold、Pranab Choudhury

  DOI：10.1016/s0022-328x(00)90118-9

  日期：1977.3

  Dibenzylmercury is a convenient and general reagant for the formation of homoatomic catenates from primary alkyl phosphines, arsines and stibines. From CH3PH2, CH3AsH2 and C2H5AsH2, the products are Hgo and the cyclopentamers, (CH3P)5, (CH3As)5 and (C2H5As)5, respectively. From CH3SbH2, the solid, polymeric product, (CH3Sb)x, is obtained. With (CH3)2AsH, both the condensation product, (CH3)2AsAs(CH3)2

  二苄基汞是用于由伯烷基膦，rs和stibines形成同原子链烯酸酯的方便且通用的试剂。由CH 3 PH 2，CH 3 AsH 2和C 2 H 5 AsH 2生成的产物为Hg o和环戊二烯，（CH 3 P）5，（CH 3 As）5和（C 2 H 5 As）5，分别。从CH 3 SbH 2，获得固体聚合物产物（CH 3 Sb）x。带有（CH3）2 AsH，既得到缩合产物（CH 3）2 AsAs（CH 3）2，又得到了取代产物（CH 3）2 AsCH 2 C 6 H 5。对于二苄基汞，CH 3 PCl 2，CH 3 AsCl 2和CH 3 SbCl 2仅给出单取代产物CH 3 E（Cl）CH 2 C 6 H 5（E = P，As或Sb）和HgCl 2。带有CH 3AsI 2会发生分解，从而产生（除HgI 2之外）CH 3 As（CH 2 C 6 H 5）2，并与（CH 3）2 AsI，（CH 3）2