2-羟基-1-萘磺酸 | 567-47-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2-羟基-1-萘磺酸
• 英文名称: 2-hydroxy-naphthalene-1-sulfonic acid
• 英文别名: 1-Naphthalenesulfonic acid, 2-hydroxy-；2-hydroxynaphthalene-1-sulfonic acid
• CAS: 567-47-5
• 化学式: C₁₀H₈O₄S
• 分子量: 224.237
• InChiKey: SGBQUMZTGSQNAO-UHFFFAOYSA-N

物化性质

• 沸点：
  335.63°C (rough estimate)
• 密度：
  1.4643 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  4

制备方法与用途

化学性质上，它能溶于水。主要用作萘普生的中间体。

反应信息

• 作为反应物：
  描述：

  2-羟基-1-萘磺酸 在 ammonium disulfite 、 氨 作用下， 生成 2-萘胺-1-磺酸
  参考文献：
  名称：

  I. G. Farbenind., Manufacture of Intermediates for Dyestuffs, Bios Final Report Nr. 986, S. 393

  摘要：

  DOI：
• 作为产物：
  描述：

  1-氯-2-萘酚 在 sodium persulfate 、 sodium sulfite 作用下， 以 水 为溶剂， 生成 2-羟基-1-萘磺酸
  参考文献：
  名称：

  Ivanov, V. L.; Savvina, V. S.; Eggert, L., Journal of Organic Chemistry USSR (English Translation), 1989, vol. 25, # 10.2, p. 1941 - 1944

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS<br/>[FR] SULFONAMIDES SUBSTITUÉS UTILES COMME INHIBITEURS DE BCL ANTI-APOPTOTIQUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2012162365A1

  公开（公告）日：2012-11-29

  Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.

  揭示了式（I）的化合物或其药学上可接受的盐，其中：W、Q和G在此处被定义。还揭示了将这些化合物用作Bcl-2家族抗凋亡蛋白的抑制剂以治疗癌症的方法；以及包含这些化合物的药物组合物。
• Erianin Salts, Their Preparation Methods and Pharmaceutical Compositions Containing the Same
  申请人：Li Yiping

  公开号：US20080306028A1

  公开（公告）日：2008-12-11

  This invention relates to a kind of Erianin salt and the preparing process thereof. The said Erianin salt is a compound with the following general formula (I), wherein R is the salt formed by monobasic acid radical of inorganic oxacid combining with metals, ammonium salts, organic amine. This invention also relates to a pharmaceutical composition comprising Erianin salt. Compared with Erianin, the said Erianin salt has far better solubility, which can improve the bioavailability and show better antineoplastic efficacy.

  这项发明涉及一种Erianin盐及其制备过程。所述的Erianin盐是具有以下一般化学式（I）的化合物，其中R是由无机氧酸的一元酸基与金属、铵盐、有机胺结合形成的盐。该发明还涉及一种包含Erianin盐的药物组合物。与Erianin相比，所述的Erianin盐具有更好的溶解性，可提高生物利用度并显示更好的抗肿瘤效果。
• MACROMOLECULAR CONJUGATES OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREFOR
  申请人：Verkman Alan S.

  公开号：US20080171793A1

  公开（公告）日：2008-07-17

  Provided herein are bioactive agents comprising a compound that inhibits the ion transport activity of a cystic fibrosis transmembrane conductance regulator (CFTR) and that is linked to a macromolecule that interacts with a cell that expresses CFTR. The bioactive agents described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, secretory diarrhea.

  本文提供了生物活性剂，其中包括一种抑制囊性纤维化跨膜导电调节因子（CFTR）离子传输活性的化合物，并且与与表达CFTR的细胞相互作用的大分子相连。本文所描述的生物活性剂可用于治疗与CFTR活性异常增加相关的疾病、疾病后遗症和疾病、疾病后遗症和病症，例如分泌性腹泻。
• [EN] FIBRE-REACTIVE AZO DYES, THEIR PREPARATION AND THEIR USE<br/>[FR] COLORANTS AZO REACTIFS, LEUR PREPARATION ET LEUR UTILISATION
  申请人：CIBA SC HOLDING AG

  公开号：WO2004013235A1

  公开（公告）日：2004-02-12

  Reactive dyes of formula (I), wherein A is the radical of a monoazo, polyazo, metal complex azo, anthraquinone, phthalocyanine, formazan or dioxazine chromophore, Q1, and Q2 are each independently of the other hydrogen or unsubstituted or substituted C1,-C4alkyl, (Q3)n denotes n substituents selected from the group C1,-C4alkyl, C1-C4alkoxy, halogen and sulfo, X is halogen, 3-carboxypyridin-1-yl, 3-carbamoylpyridin-1-yl, hydroxy, C1-C4alkoxy unsubstituted or substituted in the alkyl moiety, phenoxy unsubstituted or substituted in the phenyl moiety, C1-C4alkylthio unsubstituted or substituted in the alkyl moiety, unsubstituted or substituted amino, or an N-heterocycle which may or may not contain further hetero atoms, Y is vinyl or a radical -CH2-CH2-U and U is a group removable under alkaline conditions, k is a number 2, 3, 4, 5 or 6, m is a number 0 or 1, and n is a number 0, 1 or 2, with the proviso that when A denotes a monoazo chromophore it is not directly linked to the triazinyl radical through a hydroxynaphthalenesulfonic acid coupling component and does not denote a radical of formula (II), are suitable for dyeing cellulosic or nitrogen-containing fibre materials.

  式(I)的反应染料中，其中A是单偶氮基团、多偶氮基团、金属络合偶氮基团、蒽醌基团、酞菁基团、福尔马赞基团或二氧嗪基团的基团，Q1和Q2各自独立地是氢或未取代或取代的C1-C4烷基，(Q3)n表示从C1-C4烷基、C1-C4烷氧基、卤素和磺酸基团组中选择的n个取代基团，X是卤素、3-羧基吡啶-1-基、3-氨基甲酰基吡啶-1-基、羟基、未取代或取代的C1-C4烷氧基、未取代或取代的苯氧基、未取代或取代的C1-C4烷硫基、未取代或取代的氨基或可能包含进一步杂原子的N-杂环，Y是乙烯基或基团-CH2-CH2-U，U是在碱性条件下可除去的基团，k是数字2、3、4、5或6，m是数字0或1，n是数字0、1或2，但是当A表示单偶氮基团时，它不是通过羟基萘磺酸偶联组分直接连接到三嗪基团，并且不表示式(II)的基团，适用于染色纤维素或含氮纤维材料。
• INK JET INK COMPOSITION
  申请人：Seiko Epson Corporation

  公开号：US20180094153A1

  公开（公告）日：2018-04-05

  An ink jet ink composition contains a disperse dye, and a compound represented by the following formula (1): In the formula, Ar 1 and Ar 2 each independently represent an aryl group; R 1 and R 2 each independently represent a chemical species selected from the group consisting of hydrogen, alkyl groups having a carbon number of 1 to 3, a sulfo group, —O—SO 3 H, a carboxy group, and a hydroxy group; and n's each independently represent an integer of 0 to 5.

  一种喷墨墨水组成包含一种分散染料和一种由以下式子（1）表示的化合物： 在式子中，Ar1和Ar2各自独立地表示一个芳基基团；R1和R2各自独立地表示从氢、碳数为1到3的烷基基团、磺基、—O—SO3H、羧基和羟基组成的化学物种；n各自独立地表示0到5的整数。