FTY720 phosphonate | 402615-93-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: FTY720 phosphonate
• 英文别名: 3-Amino-3-hydroxymethyl-5-(4-octylphenyl)pentylphosphonic acid；[3-Amino-3-hydroxymethyl-5-(4-octyl-phenyl)-pentyl]-phosphonic acid；[3-amino-3-(hydroxymethyl)-5-(4-octylphenyl)pentyl]phosphonic acid
• CAS: 402615-93-4
• 化学式: C₂₀H₃₆NO₄P
• 分子量: 385.484
• InChiKey: XDSPSYJWGHPIAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  26
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Phosphate derivatives as immunoregulatory agents
  申请人：——

  公开号：US20020091105A1

  公开（公告）日：2002-07-11

  Immunoregulatory compounds are disclosed of the formula: 1 and 2 as well as the pharmaceutically acceptable salts and hydrates thereof, are disclosed. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.

  揭示了具有以下式子的免疫调节化合物：1和2以及其药用盐和水合物。这些化合物可用于治疗免疫介导的疾病和状况，如骨髓、器官和组织移植排斥。包括药物组成和使用方法。
• [EN] PHOSPHATE DERIVATIVES AS IMMUNOREGULATORY AGENTS<br/>[FR] DERIVES DE PHOSPHATES UTILISES EN TANT QU'AGENTS IMMUNO-REGULATEURS
  申请人：MERCK & CO INC

  公开号：WO2002018395A1

  公开（公告）日：2002-03-07

  Immunoregulatory compounds are disclosed of the formula: and as well as the pharmaceutically acceptable salts and hydrates thereof, are disclosed. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.

  公开了如下式的免疫调节化合物：以及其药学上可接受的盐和水合物。该化合物可用于治疗免疫介导的疾病和病况，如骨髓、器官和组织移植排斥反应。还包括制药组合物和使用方法。
• Method Of Treating Acute Lung Injury Using Sphingosine 1 Phosphate Analogs Or Sphingosine 1 Phosphate Receptor Agonists
  申请人：Garcia Joe G.N.

  公开号：US20130079309A1

  公开（公告）日：2013-03-28

  The invention provides methods for treating or reducing the risk of developing acute lung injury manifested by increased vascular permeability. Also provided are pharmaceutical compositions comprising an FTY720 analog or derivative and/or SEW 2871 for use in the disclosed methods. The invention also provides methods for treating or reducing the risk of developing acute lung injury resulting from dysregulation of ceramide/sphingolipid pathway, more specifically, acute lung injury resulting from radiation.

  本发明提供了治疗或减少因增加血管通透性而表现为急性肺损伤的方法。还提供了包含FTY720类似物或衍生物和/或SEW 2871的药物组合物，用于所述方法。本发明还提供了治疗或减少因鞘氨醇/鞘脂代谢通路失调而导致的急性肺损伤的方法，更具体地说，是由放射线引起的急性肺损伤。
• Stabilization of alcohol intoxication-induced cardiovascular instability
  申请人：Breslin Jerome William

  公开号：US10111841B2

  公开（公告）日：2018-10-30

  The present invention concerns use of an agent that increases sphingosine-1-phosphate (S1P) receptor activity, such as S1P, or an S1P receptor agonist, for treatment of alcohol-intoxicated subjects will help stabilize blood pressure and improve resuscitation efforts in alcohol-intoxicated subjects, including alcohol-intoxicated trauma patients. Another aspect concerns a kit for stabilization of alcohol-intoxicated subjects, comprising an agent that increases S1P receptor activity.

  本发明涉及一种增加鞘氨醇-1-磷酸（S1P）受体活性的药剂，如 S1P 或 S1P 受体激动剂，用于治疗酒精中毒者，将有助于稳定血压和改善酒精中毒者（包括酒精中毒的创伤患者）的复苏工作。另一个方面涉及一种用于稳定酒精中毒受试者的试剂盒，其中包含一种能提高 S1P 受体活性的制剂。
• PHOSPHATE DERIVATIVES AS IMMUNOREGULATORY AGENTS
  申请人：Merck & Co., Inc.

  公开号：EP1315735A1

  公开（公告）日：2003-06-04