N'-(5-hydroxynaphthalen-1-yl)-N,N-dimethylimidoformamide | 195322-24-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N'-(5-hydroxynaphthalen-1-yl)-N,N-dimethylimidoformamide
• 英文别名: N'-(5-hydroxynaphthalen-1-yl)-N,N-dimethylmethanimidamide
• CAS: 195322-24-8
• 化学式: C₁₃H₁₄N₂O
• 分子量: 214.267
• InChiKey: TUXXEFYUXISDSC-UHFFFAOYSA-N

物化性质

• 沸点：
  387.9±34.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  α-(甲氨甲基)苯甲醇 、 3,5-二甲氧基苄基氯 、 N'-(5-hydroxynaphthalen-1-yl)-N,N-dimethylimidoformamide 生成 2-[(3,5-dimethoxyphenyl)methoxy]-N-methyl-2-phenylethanamine
  参考文献：
  名称：

  Annovel formamidine linker for use in solid-phase synthesis

  摘要：

  A variety of amidines have been evaluated as linkers for solid-supported synthesis. As a demonstration of its utility, an amidine linker was used to prepare a set of compounds involving amine exchange, oxidation, reduction and ether formation reactions. These compounds were successfully cleaved from the support to generate alpha-substituted, secondary amine derivatives, which were thoroughly characterized by spectroscopic methods. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)01200-8
• 作为产物：
  描述：

  1-氨基-5-萘酚 、 N,N-二甲基甲酰胺二甲基缩醛 以 甲醇 为溶剂， 反应 3.0h， 生成 N'-(5-hydroxynaphthalen-1-yl)-N,N-dimethylimidoformamide
  参考文献：
  名称：

  Annovel formamidine linker for use in solid-phase synthesis

  摘要：

  A variety of amidines have been evaluated as linkers for solid-supported synthesis. As a demonstration of its utility, an amidine linker was used to prepare a set of compounds involving amine exchange, oxidation, reduction and ether formation reactions. These compounds were successfully cleaved from the support to generate alpha-substituted, secondary amine derivatives, which were thoroughly characterized by spectroscopic methods. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)01200-8

文献信息

• Annovel formamidine linker for use in solid-phase synthesis
  作者：Paul S. Furth、Michael S. Reitman、Alan F. Cook

  DOI：10.1016/s0040-4039(97)01200-8

  日期：1997.8

  A variety of amidines have been evaluated as linkers for solid-supported synthesis. As a demonstration of its utility, an amidine linker was used to prepare a set of compounds involving amine exchange, oxidation, reduction and ether formation reactions. These compounds were successfully cleaved from the support to generate alpha-substituted, secondary amine derivatives, which were thoroughly characterized by spectroscopic methods. (C) 1997 Elsevier Science Ltd.