1,4-diacetylpiperazine-2,3-diol | 960507-67-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,4-diacetylpiperazine-2,3-diol
• 英文别名: 1,4-Diacetylpiperazine-2,3-diol；1-(4-acetyl-2,3-dihydroxypiperazin-1-yl)ethanone
• CAS: 960507-67-9
• 化学式: C₈H₁₄N₂O₄
• 分子量: 202.21
• InChiKey: GMEKWURFIBHZHU-UHFFFAOYSA-N

物化性质

• 熔点：
  107-112 °C(Solvent: Acetonitrile)
• 沸点：
  462.1±45.0 °C(Predicted)
• 密度：
  1.394±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  81.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,4-diacetylpiperazine-2,3-diol 在 吡啶 、 对甲苯磺酸 、 三乙胺 作用下， 反应 0.5h， 生成 N,N'-(1,4-diacetylpiperazine-2,3-diyl)diacetamide
  参考文献：
  名称：

  Derivatives of 1,1,2,2-tetraaminoethane: II. Condensation of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with nitrogen-containing nucleophiles

  摘要：

  Reactions of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with acetamide and ethyl carbamate gave 1,3-diacetyl-4,5-bis(acetylamino)imidazolidine, 1,4-diacetyl-2,3-bis(acetylamino)piperazine, 1,3-diacetyl-4,5-bis(ethoxycarbonylamino)imidazolidine, and 1,4-diacetyl-2,3-bis(ethoxycarbonylamino)piperazine, respectively. Condensation products of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with urea, furazan-3,4-diamine, and 4-phenylfurazan-3-amine were isolated.

  DOI：

  10.1134/s1070428007040185
• 作为产物：
  描述：

  草酸醛 、 N,N-二乙酰基乙二胺 在 sodium carbonate 作用下， 以 水 为溶剂， 以90%的产率得到1,4-diacetylpiperazine-2,3-diol
  参考文献：
  名称：

  Derivatives of 1,1,2,2-tetraaminoethane: II. Condensation of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with nitrogen-containing nucleophiles

  摘要：

  Reactions of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with acetamide and ethyl carbamate gave 1,3-diacetyl-4,5-bis(acetylamino)imidazolidine, 1,4-diacetyl-2,3-bis(acetylamino)piperazine, 1,3-diacetyl-4,5-bis(ethoxycarbonylamino)imidazolidine, and 1,4-diacetyl-2,3-bis(ethoxycarbonylamino)piperazine, respectively. Condensation products of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with urea, furazan-3,4-diamine, and 4-phenylfurazan-3-amine were isolated.

  DOI：

  10.1134/s1070428007040185

文献信息

• Derivatives of 1,1,2,2-tetraaminoethane: II. Condensation of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with nitrogen-containing nucleophiles
  作者：E. V. Sizova、V. V. Sizov、I. V. Tselinskii

  DOI：10.1134/s1070428007040185

  日期：2007.4

  Reactions of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with acetamide and ethyl carbamate gave 1,3-diacetyl-4,5-bis(acetylamino)imidazolidine, 1,4-diacetyl-2,3-bis(acetylamino)piperazine, 1,3-diacetyl-4,5-bis(ethoxycarbonylamino)imidazolidine, and 1,4-diacetyl-2,3-bis(ethoxycarbonylamino)piperazine, respectively. Condensation products of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with urea, furazan-3,4-diamine, and 4-phenylfurazan-3-amine were isolated.