5a,6,7,8-tetrahydro-5H-chromeno[3,2-d]xanthene | 1068436-65-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5a,6,7,8-tetrahydro-5H-chromeno[3,2-d]xanthene
• 英文别名: 2,22-Dioxapentacyclo[12.8.0.01,10.03,8.016,21]docosa-3,5,7,9,16,18,20-heptaene
• CAS: 1068436-65-6
• 化学式: C₂₀H₁₈O₂
• 分子量: 290.362
• InChiKey: NYRIGJDKJKWKGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-环己烯氧基三甲基硅烷 、 pentafluoro-N(o-hydroxybenzyliden)aniline 在 三氟化硼乙醚 作用下， 以 苯 为溶剂， 以48%的产率得到5a,6,7,8-tetrahydro-5H-chromeno[3,2-d]xanthene
  参考文献：
  名称：

  BF3-promoted cyclization reaction of imines and salicylaldehyde with silyl enol ethers: unexpected formation of dioxaspiro compounds

  摘要：

  Unexpected spiro cyclic products were formed from the reaction of imines and salicylaldehyde with silyl enol ethers in the presence of BF(3.)OEt(2). Different kinds of dioxaspiro products were afforded depending on the nature of starting materials. Furthermore, salicylaldehyde could also react directly with several silyl enol ethers. giving three products with different spiro cyclic structure Under the same reaction conditions. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.07.019

文献信息

• BF3-promoted cyclization reaction of imines and salicylaldehyde with silyl enol ethers: unexpected formation of dioxaspiro compounds
  作者：Yong Xin、Huiling Jiang、Jingwei Zhao、Shizheng Zhu

  DOI：10.1016/j.tet.2008.07.019

  日期：2008.9

  Unexpected spiro cyclic products were formed from the reaction of imines and salicylaldehyde with silyl enol ethers in the presence of BF(3.)OEt(2). Different kinds of dioxaspiro products were afforded depending on the nature of starting materials. Furthermore, salicylaldehyde could also react directly with several silyl enol ethers. giving three products with different spiro cyclic structure Under the same reaction conditions. (C) 2008 Elsevier Ltd. All rights reserved.