(1R,2S)-1,2-diphenylpropylamine | 24435-41-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (1R,2S)-1,2-diphenylpropylamine
• 英文别名: (2S,3R)-2,3-Diphenyl-3-aminopropan；(1R,2S)-1,2-diphenylpropan-1-amine
• CAS: 24435-41-4
• 化学式: C₁₅H₁₇N
• 分子量: 211.307
• InChiKey: ONMSXYYIRIBHOQ-SWLSCSKDSA-N

物化性质

• 沸点：
  304.6±11.0 °C(Predicted)
• 密度：
  1.032±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (1R,2S)-N-(2,4,6-trimethoxyphenyl)-1-phenyl-2-{2-[(S)-p-tolylsulfinyl]phenyl}propylamine 在 镍 ammonium cerium(IV) nitrate 作用下， 以 四氢呋喃 、 水 、 乙腈 为溶剂， 反应 4.0h， 生成 (1R,2S)-1,2-diphenylpropylamine
  参考文献：
  名称：

  Pi-pi堆积与立体选择性控制中的空间效应：合成高syn-1,2-二芳基丙胺的非对映选择性。

  摘要：

  N-芳基亚烷基胺与衍生自2-（对甲苯基亚磺酰基）甲苯（S）-1和（S）-2的亚磺酰基苄基碳负离子反应，在C1处提供1,2-二芳基乙基-和1,2-二芳基丙胺衍生物的差向异构混合物。亚磺酰基完全控制（S）-2反应中C2处的构型。C1处的构型取决于与亚氨基碳原子相邻的环的电子密度，该电子密度通过与环连接至碳负离子中心的pi-pi堆积相互作用进行调节。通过用适当的取代基修饰亚芳基胺环的受体特性来控制立体选择性，通过给电子基团可以在C1上形成高选择性（R）构型。N-（2,4，

  DOI：

  10.1002/chem.200601893

文献信息

• RUTHENIUM-DIAMINE COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND
  申请人：Touge Taichiro

  公开号：US20140051871A1

  公开（公告）日：2014-02-20

  Provided is a ruthenium complex that is represented by general formula (1*) and is useful as an asymmetric reduction catalyst. (In the formula, * is an asymmetric carbon atom; R 1 is an arenesulfonyl group, and the like; R 2 and R 3 are a phenyl group, and the like; R 10 through R 14 are selected from a hydrogen atom, C 1-10 alkyl group, and the like, but R 10 through R 14 are not simultaneously hydrogen atoms; X is a halogen atom and the like; j and k are each either 0 or 1; and j+k is 0 or 2.)

  提供一个钌配合物，其由通式(1*)表示，可用作不对称还原催化剂。 (在公式中，*是不对称碳原子；R1是芳基磺酰基团等；R2和R3是苯基团等；R10至R14选自氢原子、C1-10烷基团等，但R10至R14不同时为氢原子；X是卤素原子等；j和k都是0或1；j+k为0或2。)
• METHOD FOR PREPARING A METAL CATALYST
  申请人：Abdur-Rashid Kamaluddin

  公开号：US20120046479A1

  公开（公告）日：2012-02-23

  The present disclosure relates to a method for preparing a metal catalyst comprising at least one ligand that is coordinated to the metal through at least one phosphorous (P) atom and at least one nitrogen (N) atom, the method comprising reacting a metal pre-cursor complex with an acid ad salt of an aminophosphine, diaminophosphine, aminodiphosphine or diaminodiphosphine, in the presence of a base.

  本公开涉及一种制备金属催化剂的方法，该方法包括至少一种通过至少一个磷（P）原子和至少一个氮（N）原子配位到金属的配体，所述方法包括在碱的存在下，将金属前体配合物与氨基膦、二氨基膦、氨基双膦或二氨基双膦的酸和盐反应。
• METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND, AND NOVEL METAL-DIAMINE COMPLEX
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20160347678A1

  公开（公告）日：2016-12-01

  The present invention pertains to a method for producing an optically active compound which includes a step for reducing an imino group of an imine compound or a step for reducing an unsaturated bond of a heterocyclic compound, while in the presence of hydrogen gas as a hydrogen donor and one or more types of complexes selected from a group consisting of a complex represented by general formula (1), a complex represented by general formula (2), a complex represented by general formula (3), and a complex represented by general formula (4) (the general formulas (1)-(4) are as stipulated by claim 1 ).

  本发明涉及一种制备光学活性化合物的方法，其中包括在氢气作为氢供体和从一组中选择的一种或多种类型的配合物的存在下，对亚胺化合物的亚胺基进行还原或对杂环化合物的不饱和键进行还原的步骤，所述配合物的选择自一组由一般式（1）表示的配合物、一般式（2）表示的配合物、一般式（3）表示的配合物和一般式（4）表示的配合物（一般式（1）-（4）如权利要求1所规定）。
• NOVEL DIAMINE COMPOUND AND METAL COMPLEXES, AND METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUNDS
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20150094468A1

  公开（公告）日：2015-04-02

  The present invention relates to a novel diamine compound represented by the general formula (1), a ruthenium-diamine complex, an iridium-diamine complex, and a rhodium-diamine complex having the diamine compound as a ligand. Furthermore, the present invention relates to methods for selectively producing optically active compounds by using any of these complexes as a catalyst. wherein R 1 , R 2 , R 3 , X, Y, and Z are as defined in claim 1.

  本发明涉及一种由通式（1）表示的新型二胺化合物，一种以该二胺化合物为配体的钌-二胺络合物、铱-二胺络合物和铑-二胺络合物。此外，本发明涉及利用这些络合物中的任何一种作为催化剂选择性生产光学活性化合物的方法。其中，R1、R2、R3、X、Y和Z的定义如权利要求1所述。
• METHOD FOR PRODUCING DIAMINE COMPOUND
  申请人：Touge Taichiro

  公开号：US20140039220A1

  公开（公告）日：2014-02-06

  The present invention provides a method for producing a compound represented by general formula (1) (wherein R 1 , R 2 , R 3 , R 10 -R 14 , A 1 -A 3 , n 1 and n 2 are as defined in the description), which is characterized by reacting a compound represented by general formula (2) (wherein R 10 -R 14 , A 1 -A 3 , n 1 , n 2 and B are as defined in the description) with a diamine compound represented by general formula (3) (wherein R 1 -R 3 are as defined in the description). The present invention is a method for producing a diamine compound, which is useful for the formation of a ruthenium-diamine complex, under mild conditions, said method being able to be put in industrial practice.

  本发明提供了一种生产通式（1）所代表的化合物的方法（其中R1、R2、R3、R10-R14、A1-A3、n1和n2如说明书所定义），其特征在于将通式（2）所代表的化合物（其中R10-R14、A1-A3、n1、n2和B如说明书所定义）与通式（3）所代表的二胺化合物（其中R1-R3如说明书所定义）反应。本发明是一种生产二胺化合物的方法，该方法适用于在温和条件下形成钌-二胺配合物，且能够在工业实践中应用。