2-Methyl-cyclobutylamin-(1) | 89381-05-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Methyl-cyclobutylamin-(1)
• 英文别名: 2-Methylcyclobutan-1-amine
• CAS: 89381-05-5
• 化学式: C₅H₁₁N
• mdl: MFCD19206689
• 分子量: 85.149
• InChiKey: YYMQZXMSPLVJJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  6
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Methyl-cyclobutylamin-(1) 在 sodium hydride 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationship of new 1-substituted derivatives

  摘要：

  A series of novel 7-piperazinyl-1-substituted-6-fluoroquinolones and naphthyridines have been prepared and their antibacterial activities evaluated. These derivatives are characterized by having alkyl, alkenyl, arylalkyl, cycloalkyl, and cycloalkenyl groups at the 1-position. As a result of this study, derivatives 7 and 26, which are substituted with tert-butyl groups at N-1, were found to possess excellent in vitro and in vivo potency, particularly against Staphylococcus aureus, comparable to that of norfloxacin or ciprofloxacin. Structure-activity relationships of N-1 substituted alkyls and cycloalkyls are also discussed.

  DOI：

  10.1021/jm00123a005
• 作为产物：
  描述：

  2-methylcyclobutane-1,1-dicarboxylic acid 在 sodium azide 、 硫酸 作用下， 以 氯仿 为溶剂， 生成 2-Methyl-cyclobutylamin-(1)
  参考文献：
  名称：

  小环化合物。三十五。甲基取代的环丁基-、环丙基羰基-和烯丙基羰基胺的亚硝酸脱氨基重排的研究1a,b

  摘要：

  已确定在环丙基甲基甲胺、(2-甲基环丙基)-甲胺、2-甲基环丁胺、3-甲基环丁胺、巴豆基甲胺和烯丙基甲基甲胺的亚硝酸脱氨基中形成的醇混合物的组成。这些结果和相应醇在强酸性介质中异构化条件下的行为可以通过假设形成三种不等价的、不对称的、非经典的阳离子中间体来解释，类似于先前为其他小环衍生物的碳正离子反应提出的那些。 .

  DOI：

  10.1021/ja01478a028

文献信息

• Small-Ring Compounds. XXXV. Studies of Rearrangements in the Nitrous Acid Deaminations of Methyl-substituted Cyclobutyl-, Cyclopropylcarbinyl- and Allylcarbinylamines^1a,b
  作者：Marc S. Silver、Marjorie C. Caserio、Howard E. Rice、John D. Roberts

  DOI：10.1021/ja01478a028

  日期：1961.9

  compositions of the alcohol mixtures formed in nitrous acid deaminations of cyclopropylmethylcarbinylamine, (2-methylcyclopropyl)-carbinylamine, 2-methylcyclobutylamine, 3-methylcyclobutylamine, crotylcarbinylamine and allylmethylcarbinylamine have been determined. These results and the behavior of the corresponding alcohols under isomerization conditions in strongly acidic media may be explained by assuming formation

  已确定在环丙基甲基甲胺、(2-甲基环丙基)-甲胺、2-甲基环丁胺、3-甲基环丁胺、巴豆基甲胺和烯丙基甲基甲胺的亚硝酸脱氨基中形成的醇混合物的组成。这些结果和相应醇在强酸性介质中异构化条件下的行为可以通过假设形成三种不等价的、不对称的、非经典的阳离子中间体来解释，类似于先前为其他小环衍生物的碳正离子反应提出的那些。 .
• Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationship of new 1-substituted derivatives
  作者：D. Bouzard、P. Di Cesare、M. Essiz、J. P. Jacquet、P. Remuzon、A. Weber、T. Oki、M. Masuyoshi

  DOI：10.1021/jm00123a005

  日期：1989.3

  A series of novel 7-piperazinyl-1-substituted-6-fluoroquinolones and naphthyridines have been prepared and their antibacterial activities evaluated. These derivatives are characterized by having alkyl, alkenyl, arylalkyl, cycloalkyl, and cycloalkenyl groups at the 1-position. As a result of this study, derivatives 7 and 26, which are substituted with tert-butyl groups at N-1, were found to possess excellent in vitro and in vivo potency, particularly against Staphylococcus aureus, comparable to that of norfloxacin or ciprofloxacin. Structure-activity relationships of N-1 substituted alkyls and cycloalkyls are also discussed.