2-n-Amylamino-benzthiazol | 51661-20-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-n-Amylamino-benzthiazol
• 英文别名: 2-n-Pentylamino-benzthiazol；benzothiazol-2-yl-pentyl-amine；N-pentyl-1,3-benzothiazol-2-amine
• CAS: 51661-20-2
• 化学式: C₁₂H₁₆N₂S
• mdl: MFCD11120524
• 分子量: 220.338
• InChiKey: MGGTVBAERMKNSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-戊基-N'-苯基硫脲 在 lead(II) dihydrogen orthophosphate 、 H2 、 buffer solution 作用下， 以 甲醇 为溶剂， 反应 1.5h， 生成 2-n-Amylamino-benzthiazol
  参考文献：
  名称：

  El-Meligy,M.S.A.; Mohamed,S.A., Journal fur praktische Chemie (Leipzig 1954), 1974, vol. 316, p. 154 - 158

  摘要：

  DOI：

文献信息

• METHOD FOR PRODUCING 2-HYDRAZINOBENZOTHIAZOLE DERIVATIVE
  申请人：DIC Corporation

  公开号：US20200165215A1

  公开（公告）日：2020-05-28

  The present invention provides a novel method for producing a 2-hydrazinobenzothiazole derivative. The present invention also provides a method for producing a compound by using the 2-hydrazinobenzothiazole derivative obtained by the production method, and a composition that contains the compound. The present invention also provides a polymerizable composition that is useful in producing film-shaped polymers and contains the compound obtained by the production method. The invention of the present application provides a method for producing a compound represented by general formula (I-C), the method including a step of reacting a compound represented by general formula (I-B) with a compound represented by general formula (I-A) in the presence of at least one compound selected from the group consisting of metal amides, metal hydrides, metal alkoxides, and organic alkali metals. A compound derived from the compound produced by the production method, and a composition that contains the compound are also provided.

  本发明提供一种生产2-联苯并噻唑酮衍生物的新方法。本发明还提供一种通过使用通过生产方法获得的2-联苯并噻唑酮衍生物生产化合物的方法，以及含有该化合物的组合物。本发明还提供一种可用于生产膜状聚合物的可聚合组合物，其中包含通过生产方法获得的化合物。本申请的发明提供了一种生产通式(I-C)所代表的化合物的方法，该方法包括在至少选择自金属胺、金属氢化物、金属烷氧化物和有机碱金属组成的群体中，通过将通式(I-B)所代表的化合物与通式(I-A)所代表的化合物在存在下反应的步骤。还提供了通过生产方法产生的化合物衍生物以及含有该化合物的组合物。
• Benzothiazolyl derivatives
  申请人：——

  公开号：US20040266845A1

  公开（公告）日：2004-12-30

  The present invention relates to compounds of formula (I) 1 wherein R 1 , R 2 , R 3° R 3a and R 3b are as provided in the description, and pharmaceutically acceptable salts thereof, for use in the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors such as obesity.

  本发明涉及式(I)1的化合物，其中R1、R2、R3°R3a和R3b如描述中所述，并且其药学上可接受的盐，用于治疗和/或预防与调节CB1受体相关的疾病，如肥胖。
• Novel pyridine compounds, process for their preparation and compositions containing them
  申请人：Pal Manojit

  公开号：US20060084644A1

  公开（公告）日：2006-04-20

  The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

  本发明提供了新的杂环化合物，特别是取代的吡啶，制备和使用这些杂环化合物的方法和组合物，以及治疗各种疾病和疾病状态的方法，包括动脉粥样硬化、关节炎、再狭窄、糖尿病肾病或血脂异常，或由Perlecan低表达介导的疾病状态。
• Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals
  申请人：Aventis Pharma Deutschland GmbH

  公开号：EP1388341A1

  公开（公告）日：2004-02-11

  The present invention relates to acylamino-substituted heteroaromatic compounds of the formula I, in which R1, R2, R3, R4 and R5 and X have the meanings indicated in the claims. The compounds of formula I are valuable pharmaceutically active compounds which are useful in the treatment of various disease states including cardiovascular disorders such as atherosclerosis, thrombosis, coronary artery disease, hypertension and cardiac insufficiency. They upregulate the expression of the enzyme endothelial nitric oxide (NO) synthase and can be applied in conditions in which an increased expression of said enzyme or an increased NO level or the normalization of a decreased NO level is desired. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

  本发明涉及式 I 的酰氨基取代的杂芳香族化合物、 其中 R1、R2、R3、R4 和 R5 以及 X 具有权利要求中所述的含义。式 I 化合物是有价值的药物活性化合物，可用于治疗各种疾病，包括心血管疾病，如动脉粥样硬化、血栓形成、冠状动脉疾病、高血压和心功能不全。它们能上调内皮一氧化氮（NO）合成酶的表达，可用于需要增加所述酶的表达或提高 NO 水平或使降低的 NO 水平恢复正常的情况。本发明还涉及式 I 化合物的制备工艺、其用途（尤其是作为药物的活性成分）以及包含它们的药物制剂。
• Method for producing polymerizable compound
  申请人：DIC Corporation

  公开号：US10927087B2

  公开（公告）日：2021-02-23

  The polymerizable compound has a hydrazone moiety. The present invention also provides a polymerizable composition in which discoloration and reduction of aligning property do not easily occur. Furthermore, the present invention provides a polymer obtained by polymerizing a polymerizable composition containing a compound obtained by the production method and an optically anisotropic body using the polymer. The present invention provides a method for producing a polymerizable compound including a step of reacting a compound represented by General Formula (I-B-a) with a compound represented by General Formula (I-B-b) to obtain a compound represented by General Formula (I-C), and provides a composition which contains a compound obtained by this production method.

  可聚合化合物具有腙分子。本发明还提供了一种不易发生变色和对准性能降低的可聚合组合物。此外，本发明还提供了一种通过聚合含有通过上述生产方法获得的化合物的可聚合组合物和使用该聚合物的光学各向异性体而获得的聚合物。本发明提供了一种生产可聚合化合物的方法，包括通式(I-B-a)代表的化合物与通式(I-B-b)代表的化合物反应得到通式(I-C)代表的化合物的步骤，并提供了一种含有通过该生产方法得到的化合物的组合物。