(2-Dimethyl-amino-ethyl)-guanidin | 13845-75-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2-Dimethyl-amino-ethyl)-guanidin
• 英文别名: 1-[2-(dimethylamino)ethyl]guanidine
• CAS: 13845-75-5
• 化学式: C₅H₁₄N₄
• 分子量: 130.193
• InChiKey: JKCZLILBALEVRB-UHFFFAOYSA-N

物化性质

• 沸点：
  189.3±42.0 °C(Predicted)
• 密度：
  1.08±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  67.6
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-二氯苯乙酸甲酯 、 (2-Dimethyl-amino-ethyl)-guanidin 以 异丙醇 为溶剂， 生成 N-[2-(2,6-Dichloro-phenyl)-acetyl]-N'-(2-dimethylamino-ethyl)-guanidine
  参考文献：
  名称：

  Bream; Lauener; Picard, Arzneimittel-Forschung/Drug Research, 1975, vol. 25, # 10, p. 1477 - 1482

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N-二甲基乙二胺 生成 (2-Dimethyl-amino-ethyl)-guanidin
  参考文献：
  名称：

  Pharmacologically active guanidine compounds

  摘要：

  这些化合物是取代的硫代烷基、氨基烷基和氧烷基胍，它们是组胺活性的抑制剂。

  公开号：

  US03950333A1

文献信息

• Compounds
  申请人：SMITH KLINE & FRENCH LABORATORIES LIMITED

  公开号：EP0403198A3

  公开（公告）日：1992-02-12

  Polymers of structure: in which, R¹ and R² are each C₁₋₄alkyl, or one is C₁₋₄alkyl and the other is -(CH₂)nR³; n is 2 to 12;R3 is NR4R5 or R6R7R8 X R⁴ and R⁵ are the same or different and are each hydrogen, C₁₋₄alkyl, C(=NH)NH₂, or together with the nitrogen atom to which they are attached form a saturated or unsaturated ring optionally containing one or more further heteroatoms. R⁶, R⁷ and R⁸ are the same or different and are each hydrogen, C₁₋₄alkyl or one of R⁶, R⁷ and R⁸ is C₁₋₄alkyl and the other two together with the nitrogen atom to which they are attached form a saturated or unsaturated ring optionally containing one or more further heteroatoms; a, b and c are numbers which indicate the relative molar percentages of the units present in said polymer, (b) being from 1 to 10 molar percent, and (c) being from 30 to 98 molar percent; and X⊖ is a counter ion, processes for their preparation, pharmaceutical compositions containing them and their use in therapy as cholesterol lowering agents.

  结构聚合物：其中，R¹和R²各自是C₁₋₄烷基，或者一个是C₁₋₄烷基，另一个是-(CH₂)nR³；n为2到12；R³为NR4R5或R6R7R8中的一种；R⁴和R⁵相同或不同，分别为氢、C₁₋₄烷基、C(=NH)NH₂，或者与它们连接的氮原子一起形成一个饱和或不饱和的环，可选地含有一个或多个进一步的杂原子；R⁶、R⁷和R⁸相同或不同，分别为氢、C₁₋₄烷基，或者R⁶、R⁷和R⁸中的一个是C₁₋₄烷基，另外两个与它们连接的氮原子一起形成一个饱和或不饱和的环，可选地含有一个或多个进一步的杂原子；a、b和c是相对摩尔百分比指示所述聚合物中存在的单元，其中(b)为1到10摩尔百分比，(c)为30到98摩尔百分比；X⊖是一个计数离子，它们的制备方法，含有它们的制药组合物及其作为降低胆固醇药物的用途。
• Certain thiazole, isothiazole, oxazole, and isoxazole compounds
  申请人：Smith Kline & French Laboratories Limited

  公开号：US04022797A1

  公开（公告）日：1977-05-10

  The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-guanidines which are inhibitors of histamine activity.

  这些化合物是替代硫代烷基、氨基烷基和氧基烷基鸟氨酸，它们是组胺活性的抑制剂。
• Pharmacologically active guanidine compounds for inhibiting H-2
  申请人：Smith Kline & French Laboratories Limited

  公开号：US04221802A1

  公开（公告）日：1980-09-09

  The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-guanidines which are inhibitors of histamine activity.

  这些化合物是取代的硫代烷基、氨基烷基和氧烷基胍，它们是组胺活性的抑制剂。
• Pharmacologically active thiadiazole guanidine compounds
  申请人：Smith Kline & French Laboratories Limited

  公开号：US04228291A1

  公开（公告）日：1980-10-14

  The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-guanidines which are inhibitors of histamine activity.

  这些化合物是取代的硫代烷基、氨基烷基和氧烷基鸟氨酸，它们是组胺活性的抑制剂。
• Pharmacologically active guanidine compounds as H-2 histamine receptor
  申请人：Smith Kline & French Laboratories Limited

  公开号：US04070475A1

  公开（公告）日：1978-01-24

  The compounds are substituted thioalkyl-, aminoalkyl-, and oxyalkyl-guanidines which are inhibitors of histamine activity.

  这些化合物是取代的硫代烷基、氨基烷基和氧烷基胍，它们是组胺活性的抑制剂。