2-苯基-1,4-二氮杂双环[2.2.2]辛烷 | 115609-00-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 2-苯基-1,4-二氮杂双环[2.2.2]辛烷
• 英文名称: 2-Phenyl-1,4-diazabicyclo[2.2.2]octane
• CAS: 115609-00-2
• 化学式: C₁₂H₁₆N₂
• 分子量: 188.27
• InChiKey: FCCQUKLZAKFQEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-Boc-2-苯基哌嗪 在 盐酸 、 sodium cyanoborohydride 、 碳酸氢钠 、 溶剂黄146 、 sodium iodide 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 生成 2-苯基-1,4-二氮杂双环[2.2.2]辛烷
  参考文献：
  名称：

  10.1002/anie.202406883

  摘要：

  Consuming a substantial quantum of energy (~165 TW h), the chlor‐alkali industry garners considerable scholarly and industrial interest, with the anode reaction involving the oxidation of chloride ions being a paramount determinant of reaction rates. While the dimensionally stable anode (DSA) displays commendable catalytic activity and longevity, they rely on precious metals and exhibit a non‐negligible side reaction in sodium hypochlorite (NaClO) production, underscoring the appeal of metal‐free alternatives. However, the molecules and systems currently available are characterized by intricate complexity and are not amenable to large‐scale production. Herein, we have successfully developed an economical and highly efficient molecular catalyst, demonstrating superior performance compared with the former organic molecules in the chloride ion oxidation process (COP) for the production of both chlorine gas (Cl2) and NaClO. The molecule of 2N only needs 92 mV to reach a current density of 1000mA cm‐2, with a small cost of only 0.002 $ g‐1. Furthermore, we propose a novel mechanism underpinned by non‐covalent interactions, serving as the foundation for an innovative approach to the design of efficient anodes for the COP.

  DOI：

  10.1002/anie.202406883

文献信息

• CHIRAL FLUORINATING REAGENTS
  申请人：ISIS INNOVATION LIMITED

  公开号：US20150284401A1

  公开（公告）日：2015-10-08

  This invention relates to fluorinating agents and, more particularly, to chiral non-racemic fluorinating agents useful for enantioselective fluorination, as well as to their synthesis and use and other subject matter. The fluorinating agents are based on a substituted 1,4-diazabicyclo[2.2.2]octane (DABCO) skeleton and provide electrophillic fluorine enantioselectively.

  本发明涉及氟化剂，更具体地涉及手性非外消旋氟化剂，可用于对映选择性氟化，以及它们的合成、使用和其他相关主题。该氟化剂基于取代的1,4-二氮杂双环[2.2.2]辛烷（DABCO）骨架，并提供电子亲和性氟的对映选择性。
• Crystalline complex compounds of propargyl alcohols and tertiary diamines, and process of separation and purification of propargyl alcohols using the same
  申请人：UBE INDUSTRIES, LTD.

  公开号：EP0256745A2

  公开（公告）日：1988-02-24

  Disclosed are a crystalline complex compound of a propargyl alcohol represented by Formula (I): wherein each of R₁ and R₂ represents a substituent which is different from each other and a tertiary diamine represented by Formula (II): wherein A represents a group having two carbon atoms as a chain member which may be branched; each of R₃, R₄ R₅ and R₆ may be the same or different and represents an aralkyl group or an alkyl group having l to 6 carbon atoms; and A, R₃, R₄, R₅ and R₆ may be bonded to each other, and a process of separation and purification of the propargyl alcohol using the crystalline complex compound described above.

  本发明公开了一种由式(I)代表的丙炔醇的结晶络合物： 其中 R₁ 和 R₂ 各自代表一个互不相同的取代基 和由式 (II) 代表的叔二胺： 其中 A 代表具有两个碳原子的基团作为链成员，该链成员可以是支链；R₃、R₄、R₅ 和 R₆ 中的每一个可以相同或不同，并且代表芳烷基或具有 l 至 6 个碳原子的烷基；并且 A、R₃、R₄、R₅ 和 R₆ 可以相互键合、 以及使用上述结晶复合物分离和纯化丙炔醇的工艺。
• METHOD OF PRODUCING AMMONIUM SALT COMPOUND, METHOD OF PRODUCING COMPOUND, AND COMPOUND, POLYMERIC COMPOUND, ACID GENERATOR, RESIST COMPOSITION AND METHOD OF FORMING RESIST PATTERN
  申请人：c/o Tokyo Ohka Kogyo Co., Ltd.

  公开号：US20140017617A1

  公开（公告）日：2014-01-16

  A method of producing an ammonium salt compound, including reacting a first ammonium salt compound containing a first ammonium cation which is a primary, secondary or tertiary ammonium cation with a nitrogen-containing compound having a lone pair to obtain a second ammonium salt compound which contains a conjugated acid of the nitrogen-containing compound, the conjugated acid of the nitrogen-containing compound having a larger pKa than the pKa of the first ammonium cation; and a method of producing a compound, including a step of salt exchange between the ammonium salt compound obtained by the aforementioned production method and a sulfonium cation or iodonium cation which has a higher hydrophobicity than the hydrophobicity of the conjugated acid of the nitrogen-containing compound.
• US4918190A
  申请人：——

  公开号：US4918190A

  公开（公告）日：1990-04-17
• US5043495A
  申请人：——

  公开号：US5043495A

  公开（公告）日：1991-08-27