(4-benzylpiperidin-1-yl)(4-(3,5-dibromo-4-hydroxyphenyl)thiazol-2-yl)methanone | 1192706-89-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (4-benzylpiperidin-1-yl)(4-(3,5-dibromo-4-hydroxyphenyl)thiazol-2-yl)methanone
• 英文别名: (4-benzylpiperidin-1-yl)[4-(3,5-dibromo-4-hydroxyphenyl)thiazol-2-yl]methanone；(4-benzylpiperidin-1-yl)-[4-(3,5-dibromo-4-hydroxyphenyl)-1,3-thiazol-2-yl]methanone
• CAS: 1192706-89-0
• 化学式: C₂₂H₂₀Br₂N₂O₂S
• 分子量: 536.287
• InChiKey: CLRCKAIESQSSCB-UHFFFAOYSA-N

物化性质

• 沸点：
  574.2±60.0 °C(predicted)
• 密度：
  1.617±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-bromo-1-(3,5-dibromo-4-hydroxyphenyl)ethanone 在 lithium hydroxide monohydrate 、 1-羟基苯并三唑 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 21.08h， 生成 (4-benzylpiperidin-1-yl)(4-(3,5-dibromo-4-hydroxyphenyl)thiazol-2-yl)methanone
  参考文献：
  名称：

  [EN] COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING THIAZOLE DERIVATIVES
  [FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS COMPRENANT DES DÉRIVÉS DE THIAZOLE

  摘要：

  公开号：

  WO2009131952A8

文献信息

• Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives
  申请人：Doyle Kevin James

  公开号：US20090318429A1

  公开（公告）日：2009-12-24

  The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及用于治疗动物患病的组合物和方法，该疾病对通过向需要的哺乳动物投予本文所定义的化合物的有效量（包括表1-14中列出的那些化合物或被I-XII公式所包含的化合物）或其组合物来抑制功能性囊性纤维化跨膜传导调节蛋白（CFTR）多肽作出反应，从而治疗该疾病。本发明特别涉及一种治疗腹泻和多囊性肾病的方法。
• Compounds, Compositions and Methods Comprising Thiazole Derivatives
  申请人：Doyle Kevin James

  公开号：US20100099677A1

  公开（公告）日：2010-04-22

  The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-V) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及用于治疗动物患有的对抑制功能性囊性纤维化跨膜传导调节因子（CFTR）多肽敏感的疾病的组合物和方法，通过向需要治疗的哺乳动物中投与本文所定义的化合物（包括表1-2中列出的化合物或由公式I-V所包含的化合物）或其组合物的有效量，从而治疗该疾病。本发明特别涉及治疗腹泻和多囊肾病的方法。
• Compounds, compositions and methods comprising heteroaromatic derivatives
  申请人：Doyle Kevin James

  公开号：US20100144733A1

  公开（公告）日：2010-06-10

  The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及用于治疗动物体内对抑制功能性囊性纤维化跨膜传导调节因子（CFTR）多肽敏感的疾病的组合物和方法，通过向需要治疗该疾病的哺乳动物中投与本文所定义的化合物的有效量（包括表1-14中列出的化合物或公式I-XII所包含的化合物）或其组合物，从而治疗该疾病。本发明特别涉及治疗腹泻和多囊肾病的方法。
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING THIAZOLE DERIVATIVES<br/>[FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS COMPRENANT DES DÉRIVÉS DE THIAZOLE
  申请人：INST ONEWORLD HEALTH

  公开号：WO2009131952A8

  公开（公告）日：2010-02-04