(-)-(2R,3R)-2-phenyl-3-(4-trifluoromethylphenyl)-1,4-butanediol | 474317-49-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (-)-(2R,3R)-2-phenyl-3-(4-trifluoromethylphenyl)-1,4-butanediol
• 英文别名: (2R,3R)-2-phenyl-3-[4-(trifluoromethyl)phenyl]butane-1,4-diol
• CAS: 474317-49-2
• 化学式: C₁₇H₁₇F₃O₂
• 分子量: 310.316
• InChiKey: KYCLQWICFHXTGW-HOTGVXAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  甲氧基-三氟甲基苯 、 (-)-(2R,3R)-2-phenyl-3-(4-trifluoromethylphenyl)-1,4-butanediol 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Asymmetric C C bond formation by the mixed oxidative coupling of 1,1′-bi-2-naphthyl esters

  摘要：

  Asymmetric C-C bond formation was effected by the oxidative coupling of two different ester enolates using (R)-(+)-1,1'-bi(2-naphthol) as a common tether which served to link together both ester moieties in an asymmetric environment. Reduction of the corresponding succinates afforded diastereomerically pure 2,3-disubstituted-1,4-butanediols. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00173-8
• 作为产物：
  描述：

  (R_a)-phenylacetic acid 2'-[2-(4-trifluoromethylphenyl)acetoxy][1,1']binaphthalen-2-yl ester 在 lithium aluminium tetrahydride 、 四氯化钛 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.5h， 生成 (-)-(2R,3R)-2-phenyl-3-(4-trifluoromethylphenyl)-1,4-butanediol
  参考文献：
  名称：

  Asymmetric C C bond formation by the mixed oxidative coupling of 1,1′-bi-2-naphthyl esters

  摘要：

  Asymmetric C-C bond formation was effected by the oxidative coupling of two different ester enolates using (R)-(+)-1,1'-bi(2-naphthol) as a common tether which served to link together both ester moieties in an asymmetric environment. Reduction of the corresponding succinates afforded diastereomerically pure 2,3-disubstituted-1,4-butanediols. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00173-8

文献信息

• Asymmetric C C bond formation by the mixed oxidative coupling of 1,1′-bi-2-naphthyl esters
  作者：Aurelio G. Csákÿ、M.Belén Mula、Myriam Mba、Joaquı́n Plumet

  DOI：10.1016/s0957-4166(02)00173-8

  日期：2002.5

  Asymmetric C-C bond formation was effected by the oxidative coupling of two different ester enolates using (R)-(+)-1,1'-bi(2-naphthol) as a common tether which served to link together both ester moieties in an asymmetric environment. Reduction of the corresponding succinates afforded diastereomerically pure 2,3-disubstituted-1,4-butanediols. (C) 2002 Published by Elsevier Science Ltd.