2-萘基硫酸盐 | 13146-59-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2-萘基硫酸盐
• 英文名称: 2-Naphthol sulfate
• 英文别名: sulfuric acid mono-[2]naphthyl ester；Naphthyl-(2)-hydrogensulfat；Schwefelsaeure-mono-[2]naphthylester；Mono-β-naphthylsulfat；Schwefelsaeure-mono-β-naphthylester；β-Naphthyl-schwefelsaeure；2-Naphthyl sulfate；naphthalen-2-yl hydrogen sulfate
• CAS: 13146-59-3
• 化学式: C₁₀H₈O₄S
• 分子量: 224.237
• InChiKey: HXEZIDSFDHEIIQ-UHFFFAOYSA-N

物化性质

• 密度：
  1.499±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2906299090

反应信息

• 作为反应物：
  描述：

  2-萘基硫酸盐 在 hepatopancreas β-glucosidase of Homarus americanus 作用下， 以 acetate buffer 为溶剂， 反应 0.75h， 生成 2-萘酚
  参考文献：
  名称：

  Pharmacokinetics of 2-naphthol following intrapericardial administration, and formation of 2-naphthyl- beta --glucoside and 2-naphthyl sulphate D in the American lobster, Homarus americanus

  摘要：

  1. Following a 0.25-mg/kg intrapericardial dose of the phenolic compound, 2-naphthol, to the American lobster, Homarus americanus, a two-compartment model best described the disposition of parent [C-14]-2-naphthol in the haemolymph, Male and female lobsters had similar a-phase half lives of 26 +/- 19 min (mean +/- SD, n = 4) and 29 +/- 15 min respectively. The P-phase half lives were significantly longer in males, 63.9 +/- 30.9 h, than in females, 30.6 +/- 6.8 h (p < 0.05). The total body clearance for females was 26.4 +/- 6.5 ml x h(-1) x kg(-1) and was higher than that of males, 11.1 +/- 5.9 ml x h(-1) x kg(-1) (p < 0.05).2. 2-Naphthol was converted to 2-naphthyl-beta-D-glucoside (major metabolite) and 2-naphthyl sulphate (minor metabolite) such that at 24 h 39-60.6% of the radioactivity in haemolymph was 2-naphthyl-beta-D-glucoside, 38.6-58.9% 2-naphthol and 0.5-4% 2-naphthyl sulphate.3. The 2-naphthol-derived radioactivity was > 99% bound to haemolymph proteins at 1 min and > 90% bound al 1 day after the dose, indicating that both 2-naphthol and 2-naphthyl l-P-D-glucoside were highly protein bound.4. 2-Naphthyl-beta-D-glucoside was slowly eliminated from haemolymph in both males and females, with elimination half lives of 34-78 h. 2-Naphthyl-beta-D-glucoside was the major metabolite in urine samples collected at 5 days after the dose. Hepatopancreas and antennal gland contained glucosidase activities, and the long half life of 2-naphthyl-beta-D-glucoside could be explained by conjugation-deconjugation cycling.5. 2-Naphthyl sulphate was eliminated from haemolymph with a half-life < 10 h and was excreted in urine.

  DOI：

  10.1080/004982597240389
• 作为产物：
  描述：

  萘-2-酚钾 、 alkaline earth salt of/the/ methylsulfuric acid 在 potassium carbonate 作用下， 生成 2-萘基硫酸盐
  参考文献：
  名称：

  Manufacture of sulphuric ester salts of phenols

  摘要：

  公开号：

  US02402647A1

文献信息

• Studies of hypolipidemic agents. I. Syntheses and hypolipidemic activities of 1-substituted 2-alkanone derivatives.
  作者：KAZUO OGAWA、TADAFUMI TERADA、YOSHIYUKI MURANAKA、TOSHIHIRO HAMAKAWA、SADAO HASHIMOTO、SETSURO FUJII

  DOI：10.1248/cpb.34.1118

  日期：——

  Many 1-substituted 2-alkanone derivatives were synthesized and their inhibitory activities toward pancreatic lipase and esterase were examined in order to obtain hypolipidemic agents. 1-Benzenesulfonyloxy-2-pentanone (VI-2a) and 1-(2, 4, 6-trimethylbenzenesulfonyloxy)-2-pentanone (VI-2q) exhibited not only potent and selective esterase inhibitions (IC50 : 9.0×10-7M and 1.0×10-6M, respectively), but also potent hypolipidemic action (90 and 92% reductions of plasma triglyceride, and 53 and 90% reductions of plasma total cholesterol, respectively). A novel working hypothesis is presented to account for the lowering of the plasma lipids level, i.e., that inhibition of esterase and lipase activities in the small intestinal lumen may be responsible for the decrease in the plasma lipids level.

  合成了许多1-取代的2-酮烷基衍生物，并考察了它们对胰脂肪酶和酯酶的抑制活性，以期获得降脂药物。1-苯磺酰氧基-2-戊酮（VI-2a）和1-(2, 4, 6-三甲基苯磺酰氧基)-2-戊酮（VI-2q）不仅表现出显著且具有选择性的酯酶抑制（IC50：9.0×10^-7M 和 1.0×10^-6M），而且还具有强效的降脂作用（血浆甘油三脂分别减少90%和92%，血浆总胆固醇分别减少53%和90%）。提出了一个新的工作假设来解释血浆脂质水平的降低，即小肠腔内酯酶和脂肪酶活性的抑制可能是导致血浆脂质水平下降的原因。
• Sulfonation of 1- and 2-naphthol and their methanesulfonate esters with sulfur trioxide. The influence of initial sulfation on the sulfo-product composition
  作者：Harold R. W. Ansink、Erwin Zelvelder、Hans Cerfontain

  DOI：10.1002/recl.19931120302

  日期：——

  The sulfonation of 1- and 2-naphthol with sulfur trioxide in C2H3NO2 has been studied by using 1H NMR. 1-Naphthol (1) yields, upon reaction with 1.0 mol-equiv of SO3, a mixture of 2- and 4-sulfonic acids (2- and 4-S); upon increasing the reaction temperature, the relative amount of 2-S increases. Upon reaction with 4.0 mol-equiv of SO3, the initially observed products are the hydrogen sulfate 1-O,2

  使用1 H NMR研究了1-萘酚和2-萘酚在C 2 H 3 NO 2中被三氧化硫磺化。1-萘酚（1）与1.0摩尔当量的SO 3反应，得到2-和4-磺酸（2-和4-S）的混合物。随着反应温度的升高，2-S的相对量增加。与4.0摩尔当量的SO 3反应后，最初观察到的产物是硫酸氢盐1 - O，2,4-S 3和一些相应的磺酸酐。在延长反应时间后，大约1 - O -4,7-S 3， 形成了。
• Selected acid generating agents and their use in processes for imaging radiation-sensitive elements
  申请人：——

  公开号：US20030219673A1

  公开（公告）日：2003-11-27

  An acid generating agent useful for imaging photosensitive elements selected from compounds of formulae (I), (II) and (III). 1 wherein R 1 is selected from the group consisting of an unsubstituted and substituted hydrocarbon or aryl group; wherein X is selected from the group consisting of oxygen, sulfur and selenium; wherein Y is selected from the group consisting of sulfur, selenium and tellurium; wherein Ar 1 is selected from the group consisting of an unsubstituted and substituted aryl group; wherein R 2 , R 3 and R 4 are individually selected from the group consisting of an unsubstituted and substituted hydrocarbon or aryl group or any two of them are bonded together to form a ring structure; and wherein R 5 and R 6 are individually selected from the group of an unsubstituted and substituted hydrocarbon or aryl group, or are bonded to each other to form a ring structure.

  一种酸发生剂，用于成像光敏元素，所选化合物的公式为（I），（II）和（III）。 其中，R1选自未取代和取代的烃基或芳基组； 其中，X选自氧、硫和硒组； 其中，Y选自硫、硒和碲组； 其中，Ar1选自未取代和取代的芳基组； 其中，R2、R3和R4分别选自未取代和取代的烃基或芳基组，或其中任意两个结合形成环状结构； 其中，R5和R6分别选自未取代和取代的烃基或芳基组，或结合形成环状结构。
• 有机金属亲核试剂的制造方法及使用有机金属亲核试剂的反应方法
  申请人：国立大学法人北海道大学

  公开号：CN115485255A

  公开（公告）日：2022-12-16

  第一课题是提供一种有机金属亲核试剂的制造方法，该方法通过降低有机溶剂的使用来降低环境负荷，通过不需要调整气氛和水分(湿分)从而无需使用大规模的装置，被认为是简便的手段，第二课题是提供一种能够通过一锅法等有效且简便的手段进行有机金属亲核试剂与各种有机亲电试剂的反应并在成本方面有利的反应方法，第三课题是提供一种反应性更优异的有机金属亲核试剂的简便的制造方法。作为解决手段，提供一种如下的有机金属亲核试剂的制造方法：在相对于有机卤化物1当量为0.5～10.0当量的醚化合物的存在下，通过机械化学法使有机卤化物与金属或金属化合物反应。
• Verfahren zur Herstellung von Naphthalinsulfochlorid
  申请人：BAYER AG

  公开号：EP0022538A2

  公开（公告）日：1981-01-21

  Die Erfindung betrifft ein Verfahren zur Herstellung von Naphthalinsulfochloriden durch Umsetzung der Alkalimetall-oder Ammoniumsalze der Naphthalinsulfonsäuren mit Thionylchlorid in Gegenwart von katalytisch wirksamen Substanzen und gegebenenfalls in Gegenwart von inerten Lösungs-oder Verdünnungsmitteln, das dadurch gekennzeichnet ist, daß man die Umsetzung in Gegenwart von gegebenenfalls substituierten Pyridinen, tert. aliphatischen Aminen, sekundären Amidinen und/oder quartären Ammoniumsalzen durchführt. Die Naphthalinsulfochloride dienen u.a. als Ausgangsprodukte für die Herstellung von Azofarbstoffen.

  本发明涉及一种制备萘磺酰氯的工艺，该工艺是通过萘磺酸的碱金属盐或铵盐与亚硫酰氯在催化活性物质存在下，以及任选在惰性溶剂或稀释剂存在下进行反应，其特征在于反应是在任选取代的吡啶、叔脂肪胺、仲胺和/或季铵盐存在下进行的。萘磺酰氯可作为生产偶氮染料的起始产品。