(1R,3R)-3-(4-bromophenyl)-1-[(1R,3R)-3-(4-bromophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]-1,2,3,4-tetrahydroisoquinoline | 1275550-44-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (1R,3R)-3-(4-bromophenyl)-1-[(1R,3R)-3-(4-bromophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]-1,2,3,4-tetrahydroisoquinoline
• CAS: 1275550-44-1
• 化学式: C₃₀H₂₆Br₂N₂
• 分子量: 574.358
• InChiKey: CFFXWERTSGCVCI-SKKKGAJSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  34
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (3R)-3-(4-bromophenyl)-3,4-dihydroisoquinoline 在 三甲基氯硅烷 、 锌 作用下， 以76%的产率得到(1R,3R)-3-(4-bromophenyl)-1-[(1R,3R)-3-(4-bromophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]-1,2,3,4-tetrahydroisoquinoline
  参考文献：
  名称：

  Synthesis of Gold Complexes Bearing Sterically Highly Encumbered, Chiral Carbene Ligands

  摘要：

  The synthesis of chiral carbene ligands derived from bis(tetrahydroisoquinoline) bearing sterically highly demanding, rigid substituents is described. Their corresponding gold complexes were structurally elucidated and successfully employed as catalysts for the desymmetrization of 1,4-diynamides.

  DOI：

  10.1021/om101192k

文献信息

• Synthesis of Gold Complexes Bearing Sterically Highly Encumbered, Chiral Carbene Ligands
  作者：Kristina Wilckens、Dieter Lentz、Constantin Czekelius

  DOI：10.1021/om101192k

  日期：2011.3.28

  The synthesis of chiral carbene ligands derived from bis(tetrahydroisoquinoline) bearing sterically highly demanding, rigid substituents is described. Their corresponding gold complexes were structurally elucidated and successfully employed as catalysts for the desymmetrization of 1,4-diynamides.