[9]-demethoxyshogaol | 1057075-33-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: [9]-demethoxyshogaol
• 英文别名: (E)-1-(4-hydroxyphenyl)dodec-4-en-3-one
• CAS: 1057075-33-8
• 化学式: C₁₈H₂₆O₂
• 分子量: 274.403
• InChiKey: XBDRXFITAAAGKD-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-Hydroxy-1-{4-[(trimethylsilyl)oxy]phenyl}dodecan-3-one 在 碳酸氢钠 、 盐酸 作用下， 以 甲醇 为溶剂， 生成 [9]-demethoxyshogaol
  参考文献：
  名称：

  Pharmaceutical compositions useful in prevention and treatment of beta-Amyloid protein-induced disease

  摘要：

  这项发明提供了用于治疗β-淀粉样蛋白诱导疾病的方法，以及用于相同目的的药物组合物和化合物，以及利用这些化合物制造治疗该疾病的药物的用途。更具体地说，该发明涉及利用从姜黄、银杏和姜中分离的天然产物化合物以及其合成化学类似物，用于治疗β-淀粉样蛋白诱导的疾病。

  公开号：

  US06887898B1

文献信息

• Synergistic pharmaceutical compositions useful in prevention and treatment of beta-amyloid protein-induced disease
  申请人：Kim S. H. L. Darrick

  公开号：US20070003641A1

  公开（公告）日：2007-01-04

  Disclosed are combinations of natural and synthetic turmeric, ginger, ginko biloba, sage, and rosemary compounds suitable for treatment of beta-amyloid-disease induced disease that have synergistic anti-βA peptide effects when members of the five groups of compounds are combined. Suitable members of the compounds include both natural compounds derived from extracts of each of Curcuma sp., Zingiber sp., Ginkgo biloba, Salvia sp., or Rosmarinus sp. as well as synthetic homologues and analogues of such natural compounds. Sage and rosemary derived compounds suitable alone for treatment of beta-amyloid induced disease is also described.
• Pharmaceutical Compositions Useful In Prevention and Treatment of Beta-Amyloid Protein-Induced Disease
  申请人：Kim S.H.L. Darrick

  公开号：US20080085932A1

  公开（公告）日：2008-04-10

  The invention provides methods for treating beta-Amyloid protein-induced disease, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated from turmeric, gingko biloba , and ginger, and synthetic chemical analogues thereof, for the treatment of a beta-Amyloid protein-induced disease.
• US7572829B2
  申请人：——

  公开号：US7572829B2

  公开（公告）日：2009-08-11
• US7728043B2
  申请人：——

  公开号：US7728043B2

  公开（公告）日：2010-06-01
• Pharmaceutical compositions useful in prevention and treatment of beta-Amyloid protein-induced disease
  申请人：Kim Darrick S. H. L.

  公开号：US06887898B1

  公开（公告）日：2005-05-03

  The invention provides methods for treating beta-Amyloid protein-induced disease, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated from turmeric, gingko biloba, and ginger, and synthetic chemical analogues thereof, for the treatment of a beta-Amyloid protein-induced disease.

  这项发明提供了用于治疗β-淀粉样蛋白诱导疾病的方法，以及用于相同目的的药物组合物和化合物，以及利用这些化合物制造治疗该疾病的药物的用途。更具体地说，该发明涉及利用从姜黄、银杏和姜中分离的天然产物化合物以及其合成化学类似物，用于治疗β-淀粉样蛋白诱导的疾病。