23-表-26-去羟基阿科特素 | 501938-01-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 23-表-26-去羟基阿科特素
• 英文名称: 23-epi-26-Deoxyactein
• 英文别名: [(1R,1'R,3'R,4R,4'R,5R,5'R,6'R,10'S,12'S,13'S,16'R,18'S,21'R)-1,4',6',12',17',17'-hexamethyl-18'-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyspiro[3,6-dioxabicyclo[3.1.0]hexane-4,8'-9-oxahexacyclo[11.9.0.01,21.04,12.05,10.016,21]docosane]-3'-yl] acetate
• CAS: 501938-01-8
• 化学式: C₃₇H₅₆O₁₀
• 分子量: 660.8
• InChiKey: GCMGJWLOGKSUGX-WUHYQCRDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  47
• 可旋转键数：
  4
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• Plant extraction method and extract
  申请人：Brattstrom Axel

  公开号：US20050271756A1

  公开（公告）日：2005-12-08

  A plant extract from a medical plant, preferably from Cimicifuga racemosa , is produced by treating a solid plant material with an extraction agent. preferably an aqueous alcanol, to obtain an extraction liquid containing the extract dissolved in said extraction agent; separating said extraction liquid from said solid plant material; and concentrating said extraction liquid by at least partially removing said extraction agent to produce a concentrated extract. According to the invention, concentrating the extraction liquid is effected in the presence of an effective amount of a pharmacologically acceptable and physiologically inert solution mediator. This yields a novel extract and avoids loss of constituents of the extract liquid upon concentration thereof. The extract obtained is can be used as a medication capable of binding estrogen receptors as well as progesterone receptors and is effective for treating climacteric and post menopausal distress.

  一种药用植物的植物提取物，最好来自 Cimicifuga racemosa 本发明的制备方法是：用萃取剂（最好是烷醇水溶液）处理固体植物材料，得到含有溶解在所述萃取剂中的提取物的萃取液；将所述萃取液与所述固体植物材料分离；通过至少部分去除所述萃取剂浓缩所述萃取液，得到浓缩提取物。根据本发明，提取液的浓缩是在有效量的药理学上可接受的生理惰性溶液介质存在下进行的。这样可以得到一种新的提取物，并避免提取液中的成分在浓缩时流失。获得的萃取液可用作药物，能够结合雌激素受体和孕酮受体，对治疗更年期和绝经后的痛苦有效。
• Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents
  申请人：Wilson Michelle

  公开号：US20050276836A1

  公开（公告）日：2005-12-15

  A vaginal device for delivering therapeutical and/or health-promoting agents. The vaginal device partly or completely coated by, covered by or combined with a coating or covering comprising a film, foam, strip, cap, cup or particles. The coating of the device comprises a mucoadhesive composition comprising a therapeutical and/or health-promoting agent.

  一种用于输送治疗和/或促进健康药物的阴道装置。该阴道装置部分或全部由薄膜、泡沫、条、盖、杯或颗粒组成的涂层或覆盖物涂覆、覆盖或结合。该装置的涂层包括一种粘液粘合剂组合物，其中含有治疗剂和/或促进健康剂。
• PLANT EXTRACTION METHOD AND EXTRACT
  申请人：Max Zeller Söhne AG

  公开号：EP1644015A1

  公开（公告）日：2006-04-12
• COATED VAGINAL DEVICES FOR VAGINAL DELIVERY OF THERAPEUTICALLY EFFECTIVE AND/ OR HEALTH-PROMOTING AGENTS
  申请人：UMD, Inc.

  公开号：EP1776071A2

  公开（公告）日：2007-04-25
• METHOD FOR ISOLATING CIMIRACEMATE A
  申请人：PuraPharm Company Limited

  公开号：EP2445859B1

  公开（公告）日：2014-09-24