26,27-二去甲-5beta-胆甾烷-24-酮 | 14949-16-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 26,27-二去甲-5beta-胆甾烷-24-酮
• 英文名称: 26,27-Dinor-5beta-cholestan-24-one
• 英文别名: 5-(10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)hexan-2-one
• CAS: 14949-16-7
• 化学式: C₂₅H₄₂O
• 分子量: 358.6
• InChiKey: LMGRIFIYAJHRKP-UHFFFAOYSA-N

物化性质

• 沸点：
  427.3±13.0 °C(Predicted)
• 密度：
  0.961±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• HYALURONIC ACID DERIVATIVE HAVING CATIONIC GROUP AND HYDROPHOBIC GROUP INTRODUCED THEREIN
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP3456745A1

  公开（公告）日：2019-03-20

  The present invention provides hyaluronic acid derivatives into which a certain cationic group and a certain hydrophobic group are introduced, the hyaluronic acid derivatives including one or more repeating units represented by the formula (Ia) and one or more repeating units represented by the formula (Ib).

  本发明提供了引入一定阳离子基团和一定疏水基团的透明质酸衍生物，透明质酸衍生物包括一个或多个由式（Ia）表示的重复单元和一个或多个由式（Ib）表示的重复单元。
• HYALURONIC ACID DERIVATIVE MODIFIED WITH POLY(ETHYLENE GLYCOL)
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP3712181A1

  公开（公告）日：2020-09-23

  The present invention provides hyaluronic acid derivatives including one or more of each of repeating units represented by the formulae (Ia), (Ib), and (Ic) in which certain cationic sites, certain hydrophobic sites, and certain hydrophilic sites have been introduced. In addition, the present invention provides complexes of the hyaluronic acid derivatives with a drug and pharmaceutical compositions including the hyaluronic acid derivatives, in particular, complexes of the hyaluronic acid derivatives with a drug.

  本发明提供了透明质酸衍生物，包括式(Ia)、(Ib)和(Ic)所代表的重复单元中的每个单元中的一个或多个，其中引入了某些阳离子位点、某些疏水位点和某些亲水位点。此外，本发明还提供了透明质酸衍生物与药物的复合物以及包括透明质酸衍生物的药物组合物，特别是透明质酸衍生物与药物的复合物。
• HYALURONIC ACID DERIVATIVES INTO WHICH CATIONIC AND HYDROPHOBIC GROUPS ARE INTRODUCED
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：US20190142959A1

  公开（公告）日：2019-05-16

  The present invention provides hyaluronic acid derivatives into which a certain cationic group and a certain hydrophobic group are introduced, the hyaluronic acid derivatives including one or more repeating units represented by the formula (Ia) and one or more repeating units represented by the formula (Ib).
• HYALURONIC ACID DERIVATIVE MODIFIED WITH POLYETHYLENE GLYCOL
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：US20210371548A1

  公开（公告）日：2021-12-02

  The present invention provides hyaluronic acid derivatives including one or more of each of repeating units represented by the formulae (Ia), (Ib), and (Ic) in which certain cationic sites, certain hydrophobic sites, and certain hydrophilic sites have been introduced. In addition, the present invention provides complexes of the hyaluronic acid derivatives with a drug and pharmaceutical compositions including the hyaluronic acid derivatives, in particular, complexes of the hyaluronic acid derivatives with a drug.
• [EN] HYALURONIC ACID DERIVATIVE HAVING CATIONIC GROUP AND HYDROPHOBIC GROUP INTRODUCED THEREIN<br/>[FR] DÉRIVÉ D'ACIDE HYALURONIQUE AYANT UN GROUPE CATIONIQUE ET UN GROUPE HYDROPHOBE INTRODUIT DANS CELUI-CI<br/>[JA] カチオン性基および疎水性基が導入されたヒアルロン酸誘導体
  申请人：CHUGAI PHARMACEUTICAL CO LTD

  公开号：WO2017195880A1

  公开（公告）日：2017-11-16

  式（Ｉａ）で表される１以上の繰り返し単位、および式（Ｉｂ）で表される１以上の繰り返し単位を含む、特定のカチオン性基と特定の疎水性基を導入したヒアルロン酸誘導体を提供する。