2-(4-dimethylamino-phenyl)-3,6-dimethyl-benzothiazolium; bromide | 47070-04-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-(4-dimethylamino-phenyl)-3,6-dimethyl-benzothiazolium; bromide
• 英文别名: 2-(p-Dimethylamino-phenyl)-3,6-dimethyl-benzothiazolium-bromide；2-[4-(Dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium bromide；4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline;bromide
• CAS: 47070-04-2
• 化学式: Br*C₁₇H₁₉N₂S
• 分子量: 363.321
• InChiKey: WMPDQLXFSCRILT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.77
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  35.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-dimethylamino-phenyl)-3,6-dimethyl-benzothiazolium; bromide 生成 Bis-<2-(p-dimethylamino-benzamido)-5-methyl-phenyl>-disulfid
  参考文献：
  名称：

  驱虫性季盐。3.苯并噻唑盐。

  摘要：

  DOI：

  10.1021/jm00301a008

文献信息

• [EN] DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR<br/>[FR] AGENTS DE MODULATION DE LA DIFFERENCIATION ET UTILISATIONS ASSOCIEES
  申请人：UNIV QUEENSLAND

  公开号：WO2005065686A1

  公开（公告）日：2005-07-21

  This invention discloses methods and agents for modulating the differentiation potential and/or proliferation of preadipocytes. More particularly, the present invention discloses methods and agents for modulating a fibroblast growth factor (FGF) signalling pathway, especially the FGF-1 or FGF-2 signalling pathway, for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma and lipomatosis.

  该发明揭示了调节前脂肪细胞分化潜能和/或增殖的方法和药剂。更具体地，本发明揭示了调节成纤维细胞生长因子（FGF）信号通路的方法和药剂，特别是FGF-1或FGF-2信号通路，用于治疗或预防与脂肪相关的疾病，包括但不限于肥胖、脂肪瘤和脂肪增生。
• Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes
  申请人：——

  公开号：US20030023089A1

  公开（公告）日：2003-01-30

  Novel heterocyclic compounds which generate chemiluminescence on reaction with a phosphatase enzyme are provided as well as a process for their preparation and intermediates useful therein. The compounds comprise a nitrogen, oxygen or sulfur-containing heterocyclic ring system bearing an exocyclic carbon-carbon double bond. The double bond is further substituted at the distal carbon with a phosphate group and an oxygen or sulfur atom-containing group. Novel compositions further comprising a cationic aromatic compound (CAC) in addition to the heterocyclic phosphate compound are provided. The addition of the CAC in the composition greatly increases the production of chemiluminescence and provides improved detection sensitivity. Compositions further comprising an anionic surfactant and a non-ionic surfactant provide additional improvements in detection sensitivity. The novel chemiluminescent compounds and compositions are useful in methods for producing light and in assays for phosphatase enzymes and enzyme inhibitors and in assays employing enzyme-labeled specific binding pairs.

  本发明提供了产生化学发光的新型杂环化合物，其与磷酸酶酶反应时会产生化学发光，以及用于其制备和有用中间体的方法。该化合物包括带有外向碳-碳双键的氮、氧或硫含杂环环系统。双键在远端碳上进一步取代为一个磷酸酯基团和一个含氧或硫原子的基团。此外，本发明还提供了进一步包括阳离子芳香化合物（CAC）的新型组合物，除了杂环磷酸酯化合物外。在组合物中加入CAC可以大大增加化学发光的产生，并提供改进的检测灵敏度。进一步包括阴离子表面活性剂和非离子表面活性剂的组合物提供了额外的检测灵敏度改进。新型化学发光化合物和组合物在产生光的方法、磷酸酶酶和酶抑制剂的检测方法以及使用酶标记的特异性结合对的检测方法中均有用途。
• Chemiluminescent substrates
  申请人：Beckman Coulter, Inc.

  公开号：US10703971B2

  公开（公告）日：2020-07-07

  Alkaline phosphatase chemiluminescent substrate formulations are provided exhibiting rapid incubation periods and improved stability for use in immunoassays.

  碱性磷酸酶化学发光底物制剂具有快速孵育期和更高的稳定性，可用于免疫测定。
• COMPOUNDS, COMPOSITIONS AND METHODS FOR GENERATING CHEMILUMINESCENCE WITH PHOSPHATASE ENZYMES
  申请人：LUMIGEN, INC.

  公开号：EP0819119A1

  公开（公告）日：1998-01-21
• EP0819119A4
  申请人：——

  公开号：EP0819119A4

  公开（公告）日：1999-04-14