2-phenyl-4-(thiophen-2-yl)-2,3-dihydro-1,5-benzothiazepine | 101895-73-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: 2-phenyl-4-(thiophen-2-yl)-2,3-dihydro-1,5-benzothiazepine
• 英文别名: 2-Phenyl-4-thiophen-2-yl-2,3-dihydro-1,5-benzothiazepine
• CAS: 101895-73-2
• 化学式: C₁₉H₁₅NS₂
• 分子量: 321.467
• InChiKey: OBGNGFGYESRQNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  65.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基苯硫醇盐酸盐 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 作用下， 生成 2-phenyl-4-(thiophen-2-yl)-2,3-dihydro-1,5-benzothiazepine
  参考文献：
  名称：

  Ried; Marx, Chemische Berichte, 1957, vol. 90, p. 2683,2686

  摘要：

  DOI：

文献信息

• A practical synthesis of 2,3-dihydro-1,5-benzothiazepines
  作者：Domenico C. M. Albanese、Nicoletta Gaggero、Meng Fei

  DOI：10.1039/c7gc02097j

  日期：——

  2,3-Dihydro-1,5-benzothiazepines have been obtained through a domino process involving a Michael addition of 2-aminothiophenols to chalcones, followed by in situ cyclization. Up to 98% chemical yields have been obtained at room temperature under essentially neutral conditions by using hexafluoro-2-propanol as an efficient medium.

  已经通过多米诺法获得了2，3-二氢-1，5-苯并硫氮杂s，该方法包括将2-氨基硫酚的迈克尔加成至查耳酮，然后进行原位环化。使用六氟-2-丙醇作为有效介质，在基本上中性的室温下，室温下可获得高达98％的化学收率。
• Catalyst-free synthesis of 2,3-dihydro-1,5-benzothiazepines in a renewable and biodegradable reaction medium
  作者：Neetu Yadav、Vijay B. Yadav、Mohd Danish Ansari、Hozeyfa Sagir、Ankit Verma、I. R. Siddiqui

  DOI：10.1039/c8nj05611k

  日期：——

  A clean and efficient strategy for the synthesis of benzothiazepines from chalcone and ortho-aminothiophenol has been reported.

  一种从查尔酮和邻氨基硫酚合成苯噻吩的清洁高效策略已被报道。
• ‘On water’ synthesis of 2,4-diaryl-2,3-dihydro-1,5-benzothiazepines catalysed by sodium dodecyl sulfate (SDS)
  作者：Gaurav Sharma、Raj Kumar、Asit K. Chakraborti

  DOI：10.1016/j.tetlet.2008.04.146

  日期：2008.6

  An efficient synthesis of 1,3-diaryl-2,3-dihydro-1,5-benzothiazepines has been developed by the reaction of various 1,3-diaryl-2-propenones with 2-aminothiophenol in water under neutral conditions catalysed by SDS. Excellent chemoselectivity was observed for substrates possessing halogen atoms or nitro/alkoxy/thioalkyl groups which did not undergo competitive aromatic nucleophilic substitution of the halogen atoms or the nitro group, reduction of the nitro or the a,p-unsaturated carbonyl group, or dealkylation of the alkoxy/thioalkoxy groups. (C) 2008 Elsevier Ltd. All rights reserved.
• [EN] PHENYLTHIOPHENYLDIHYDROBENZOTHIAZEPINE INHIBITORS OF STORE OPERATED CALCIUM RELEASE<br/>[FR] INHIBITEURS PHÉNYLTHIOPHÉNYLDIHYDROBENZOTHIAZÉPINE DE LIBÉRATION DE CALCIUM CAPACITIF
  申请人：CALCIMEDICA INC

  公开号：WO2010034011A9

  公开（公告）日：2010-09-30

  [EN] Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.
  [FR] L'invention concerne des composés, et des compositions pharmaceutiques contenant de tels composés, qui modulent l'activité de canaux calciques capacitifs (SOC). L'invention concerne également des procédés pour utiliser de tels modulateurs de canal SOC, seuls ou en combinaison avec d'autres composés, pour traiter des maladies, des troubles ou des états qui bénéficieraient d'une inhibition de l'activité de canal SOC.