2,4,4-trimethyl-2,3,4,5-tetrahydropyrimido<2,1-b>benzothiazole | 74204-93-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2,4,4-trimethyl-2,3,4,5-tetrahydropyrimido<2,1-b>benzothiazole
• 英文别名: 2,4,4-trimethyl-2,3-dihydropyrimido[2,1-b][1,3]benzothiazole
• CAS: 74204-93-6
• 化学式: C₁₃H₁₆N₂S
• 分子量: 232.349
• InChiKey: OUXDAGITAOMQBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-phenylthiocarbamoyl-2-phenyl-3,3,5-trimethylpyrazolidine 、 盐酸 生成 2,4,4-trimethyl-2,3,4,5-tetrahydropyrimido<2,1-b>benzothiazole
  参考文献：
  名称：

  DEEVA N. YU.; KOST A. N., XIMIYA GETEROTSIKL. SOEDIN., 1980, HO 2, 228-233

  摘要：

  DOI：

文献信息

• Aldehyde dehydrogenase (ALDH) isozymes in the gray short-tailed opossum (Monodelphis domestica): Tissue and subcellular distribution and biochemical genetics of ALDH3
  作者：Roger S. Holmes、Roland A. H. van Oorschot、John L. VandeBerg

  DOI：10.1007/bf00554209

  日期：1991.4

  Polyacrylamide gel isoelectric focusing (PAGE-IEF), cellulose acetate electrophoresis, and histochemical techniques were used to examine the tissue and subcellular distribution, genetics and biochemical properties of aldehyde dehydrogenase (ALDH) isozymes in a didelphid marsupial, the gray short-tail opossum (Monodelphis domestica). At least 14 zones of activity were resolved by PAGE-IEF and divided into five isozyme groups and three ALDH classes, based upon comparisons with properties previously reported for human, baboon, rat, and mouse ALDHs. Opossum liver ALDHs were distributed among cytosol (ALDHs 1 and 5) and large granular (mitochondrial) fractions (ALDHs 2 and 5). Similarly, kidney ALDHs were distributed between the cytosol (ALDH5) and the mitochondrial fractions (ALDHs 2, 4, and 5), whereas a major isozyme (ALDH3), found in high activity in cornea, esophagus, ear pinna, tail, and stomach extracts, was localized predominantly in the cytosol fraction. Phenotypic variants of the latter enzyme were shown to be inherited in a normal Mendelian fashion, with two alleles at a single locus (ALDH3) showing codominant expression. The data provided evidence for genetic identity of corneal, ear pinna, tail, and stomach ALDH3 and supported biochemical evidence from other mammalian species that this enzyme has a dimeric subunit structure.