3',6'-二(二甲基氨基)-5-(异硫氰酸基)螺[异苯并呋喃-1(3H),9'-[9H]氧杂蒽]-3-酮 | 20746-54-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 3',6'-二(二甲基氨基)-5-(异硫氰酸基)螺[异苯并呋喃-1(3H),9'-[9H]氧杂蒽]-3-酮
• 英文名称: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-bis(dimethylamino)-5-isothiocyanato-
• 英文别名: 3',6'-bis(dimethylamino)-6-isothiocyanatospiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 20746-54-7
• 化学式: C₂₅H₂₁N₃O₃S
• 分子量: 443.5
• InChiKey: GKMSREGJMYNJMR-UHFFFAOYSA-N

物化性质

• 沸点：
  686.8±55.0 °C(Predicted)
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  86.5
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• POLYANIONIC MULTIVALENT MACROMOLECULES FOR INTRACELLULAR TARGETING OF PROLIFERATION AND PROTEIN SYNTHESIS
  申请人：Licha Kai

  公开号：US20130095035A1

  公开（公告）日：2013-04-18

  The present invention relates generally to methods and compositions for targeting of intracellular molecules involved in proliferation and protein synthesis of activated cells using polyanionic multivalent macromolecules. In particular aspect, multiple sulfate groups linked to polyol are specifically targeted to the cytoplasm and nucleus of proliferating and activated cells. The invention further comprises novel polyanionic macromolecular compounds and formulations.
• US8877171B2
  申请人：——

  公开号：US8877171B2

  公开（公告）日：2014-11-04