3'-脱氧杀结核菌素 | 40725-89-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 中文名称: 3'-脱氧杀结核菌素
• 英文名称: 2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolan-3-ol
• CAS: 40725-89-1
• 化学式: C₁₁H₁₄N₄O₃
• 分子量: 250.25
• InChiKey: GAKDEQRUZQIUER-UHFFFAOYSA-N

物化性质

• 沸点：
  601.3±55.0 °C(Predicted)
• 密度：
  1.75±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] NUCLEOSIDE ANALOGUES FOR THE TREATMENT OF PARASITIC INFECTIONS<br/>[FR] ANALOGUES DE NUCLÉOSIDE POUR LE TRAITEMENT D'INFECTIONS PARASITAIRES
  申请人：UNIV GENT

  公开号：WO2019076633A1

  公开（公告）日：2019-04-25

  The present invention relates to novel nucleoside analogues and compositions containing said nucleoside analogues. Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the diagnosis, prevention and/or treatment of parasitic infections, more specifically for use in the diagnosis, prevention and/or treatment of a Trypanosoma infection.

  本发明涉及新型核苷类似物和含有所述核苷类似物的组合物。此外，本发明提供了制备所述化合物的方法，以及使用它们的方法，例如作为药物，特别是用于诊断、预防和/或治疗寄生虫感染，更具体地用于诊断、预防和/或治疗Trypanosoma感染。
• ADENOSINE ANALOG AND ITS USE IN REGULATING THE CIRCADIAN CLOCK
  申请人：NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING

  公开号：US20210338706A1

  公开（公告）日：2021-11-04

  The present invention provides a kind of nucleoside analogue compounds, and a composition comprising the compound and pentostatin, their use for modulating circadian rhythm, preferably, for shifting circadian phase, and methods for modulating circadian rhythm, preferably, for shifting circadian phase via the compound or the composition.
• [EN] ADENOSINE ANALOG AND ITS USE IN REGULATING THE CIRCADIAN CLOCK<br/>[FR] ANALOGUE D'ADÉNOSINE ET SON UTILISATION DANS LA RÉGULATION DE L'HORLOGE CIRCADIENNE
  申请人：NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING

  公开号：WO2018133854A1

  公开（公告）日：2018-07-26

  Provided are a kind of nucleoside analogue compounds, and compositions comprising these compounds and pentostatin, their use for modulating circadian rhythm, preferably, for shifting circadian phase, and methods for modulating circadian rhythm, preferably, for shifting circadian phase via these compounds or the compositions.