3,3'-二乙基硫代三碳菁高氯酸盐

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 中文名称: 3,3'-二乙基硫代三碳菁高氯酸盐
• 中文别名: 3,3’-二乙基硫代三碳菁高氯酸盐；3,3"-二乙基硫代三碳菁高氯酸盐
• 英文名称: 3-ethyl-2-[(2E,6E)-7-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)hepta-2,4,6-trienylidene]-1,3-benzothiazole;perchlorate
• 化学式: C25H25ClN2O4S2
• 分子量: 517.1
• InChiKey: PZQHZVAROUTGBU-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.05
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  135
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] IMAGING AGENTS AND METHODS<br/>[FR] AGENTS ET PROCÉDÉS D'IMAGERIE
  申请人：VS CHEMICKO TECHNOLOGICKA V PRAZE

  公开号：WO2018206126A1

  公开（公告）日：2018-11-15

  The invention provides methods for imaging biological tissue. The disclosed polymethenium salts show activity as two photon imaging agents, having a greater imaging depth and photostability than known agents, whilst having lower toxicity. The methods show great selectivity for mitochondria. The methods have utility in both in vitro and in vivo imaging, for example, imaging of tumours.

  本发明提供了成像生物组织的方法。所述的聚甲烯酸盐表现出双光子成像剂的活性，具有比已知剂量更大的成像深度和光稳定性，同时毒性更低。该方法对线粒体具有很强的选择性。该方法在体外和体内成像中都具有实用性，例如，肿瘤成像。
• Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes
  申请人：LI-COR, INC.

  公开号：EP0533302A1

  公开（公告）日：1993-03-24

  To sequence DNA automatically, DNA marked with near infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a scanning light frequency within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission frequency of the marked DNA. The light is modulated from said laser at a predetermined modulation frequency and fluorescent light emitted by said DNA bands at said modulation frequency is detected, whereby background noise from the medium through which the light is transmitted is discriminated against.

  为了对 DNA 进行自动测序，使用近红外荧光染料标记的 DNA 在多个通道中通过凝胶电泳板进行电泳，其中 DNA 样品根据凝胶电泳板中 DNA 片段的大小被分辨成带有荧光标记的 DNA 带。用激光二极管和传感器对分离的样品进行光电扫描，其中激光以所述荧光标记 DNA 样品吸收光谱内的扫描光频率进行扫描，光以标记 DNA 的发射频率进行感应。所述激光以预定的调制频率对光进行调制，检测所述 DNA 带在所述调制频率下发射的荧光，从而分辨出光传输介质的背景噪声。
• Digital DNA typing
  申请人：The Board of Regents of the University of Nebraska

  公开号：EP0592060A1

  公开（公告）日：1994-04-13

  To sequence DNA automatically, fluorescently marked DNA are electrophoresed in a plurality of channels through a gel electrophoresis slab; wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser and a sensor, wherein the laser scans with scanning light at a scanning light frequency within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission frequency of the marked DNA. The light is modulated from said laser at a predetermined modulation frequency and fluorescent light emitted by said DNA bands at said modulation frequency is detected, whereby background noise from the medium through which the light is transmitted is discriminated against.

  为了对 DNA 进行自动测序，在多个通道中通过凝胶电泳板对带有荧光标记的 DNA 进行电泳；根据凝胶电泳板中 DNA 片段的大小，将 DNA 样品分成带有荧光标记的 DNA 带。用激光器和传感器对分离后的样品进行光电扫描，其中激光器以所述荧光标记 DNA 样品吸光光谱内的扫描光频率进行扫描，并以标记 DNA 的发射频率对光进行感应。所述激光以预定的调制频率对光进行调制，检测所述 DNA 带在所述调制频率下发射的荧光，从而分辨出光传输介质的背景噪声。
• A method of identifying strands of DNA using infrared fluorescent labels
  申请人：LI-COR, INC.

  公开号：EP0670374A1

  公开（公告）日：1995-09-06

  The invention relates to a method of identifying strands of DNA comprising the steps of: marking the strands with fluorescent labels, irradiating the strands and detecting the light emitted from the fluorescent strands. The labels emit light in a region of wavelengths including at least one wavelength within the infrared and near infrared region wherein the fluorescent label includes a chromophore having e.g. the formula:

  本发明涉及一种识别 DNA 链的方法，包括以下步骤：用荧光标签标记 DNA 链，照射 DNA 链并检测荧光链发出的光。标签发出的光的波长区域包括红外和近红外区域内的至少一个波长，其中荧光标签包括具有如下式子的发色团：
• Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
  申请人：LI-COR, INC.

  公开号：EP0753584A1

  公开（公告）日：1997-01-15

  To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.

  为了对 DNA 进行自动测序，使用远红外、近红外或红外荧光染料标记的 DNA 在多个通道中通过凝胶电泳板或毛细管进行电泳，其中 DNA 样品在凝胶电泳板或毛细管中根据 DNA 片段的大小被分辨成荧光标记的 DNA 带。用激光二极管和传感器对分离的样品进行光电扫描，其中激光以所述荧光标记 DNA 样品吸光光谱内的波长进行扫描，光以标记 DNA 的发射波长进行感应。