(3S,4S,4aS,12aR,E)-4,12a-dimethyl-7-methylene-3-triisopropylsilyloxy-1,3,4,4a,5,8,9,12a-octahydrobenzo[10]annulene-6,10(2H,7H)-dione | 1569075-91-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (3S,4S,4aS,12aR,E)-4,12a-dimethyl-7-methylene-3-triisopropylsilyloxy-1,3,4,4a,5,8,9,12a-octahydrobenzo[10]annulene-6,10(2H,7H)-dione
• 英文别名: (1S,2S,4aR,5E,12aS)-1,4a-dimethyl-10-methylidene-2-tri(propan-2-yl)silyloxy-1,2,3,4,8,9,12,12a-octahydrobenzo[10]annulene-7,11-dione
• CAS: 1569075-91-7
• 化学式: C₂₆H₄₄O₃Si
• 分子量: 432.719
• InChiKey: MSQRJUPCSQKTHC-SSHXZLBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.03
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3S,4S,4aS,12aR,E)-4,12a-dimethyl-7-methylene-3-triisopropylsilyloxy-1,3,4,4a,5,8,9,12a-octahydrobenzo[10]annulene-6,10(2H,7H)-dione 、 potassium thiophenolate 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以43%的产率得到(4aS,4bS,7S,8S,8aS,10aS)-4b,8-dimethyl-10a-phenylthiomethyl-7-triisopropylsilyloxydecahydrophenanthrene-3,10(2H,4H)-dione
  参考文献：
  名称：

  Stereoselective construction of the ABC-ring system of fusidane triterpenes via intermolecular/transannular Michael reaction cascade

  摘要：

  A stereoselective construction of the ABC-ring system of fusidane triterpenes via intermolecular/transannular Michael reaction cascade is described. The substrate, a ten-membered carbocyclic ketone, has been successfully prepared by the Cr-mediated intramolecular alkenylation of the corresponding acyclic compound. The array of functionalities in the product stereoselectively obtained by the cascade reaction is useful for further structural modifications directed toward the total synthesis of fusidane and other triterpenes, and designed molecules intended for studying structure-activity relationships. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.071
• 作为产物：
  描述：

  ethyl 2-((1S,2S,5S,6S)-2-formyl-2,6-dimethyl-5-((triisopropylsilyl)oxy)cyclohexyl)acetate 在 吡啶 、 chromium dichloride 、 sodium hydride 、 二异丁基氢化铝 、 戴斯-马丁氧化剂 、 对甲苯磺酸 、 三乙胺 、 nickel dichloride 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 正己烷 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.84h， 生成 (3S,4S,4aS,12aR,E)-4,12a-dimethyl-7-methylene-3-triisopropylsilyloxy-1,3,4,4a,5,8,9,12a-octahydrobenzo[10]annulene-6,10(2H,7H)-dione
  参考文献：
  名称：

  Stereoselective construction of the ABC-ring system of fusidane triterpenes via intermolecular/transannular Michael reaction cascade

  摘要：

  A stereoselective construction of the ABC-ring system of fusidane triterpenes via intermolecular/transannular Michael reaction cascade is described. The substrate, a ten-membered carbocyclic ketone, has been successfully prepared by the Cr-mediated intramolecular alkenylation of the corresponding acyclic compound. The array of functionalities in the product stereoselectively obtained by the cascade reaction is useful for further structural modifications directed toward the total synthesis of fusidane and other triterpenes, and designed molecules intended for studying structure-activity relationships. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.071

文献信息

• Stereoselective construction of the ABC-ring system of fusidane triterpenes via intermolecular/transannular Michael reaction cascade
  作者：Tomohiro Fujii、Masahisa Nakada

  DOI：10.1016/j.tetlet.2014.01.071

  日期：2014.2

  A stereoselective construction of the ABC-ring system of fusidane triterpenes via intermolecular/transannular Michael reaction cascade is described. The substrate, a ten-membered carbocyclic ketone, has been successfully prepared by the Cr-mediated intramolecular alkenylation of the corresponding acyclic compound. The array of functionalities in the product stereoselectively obtained by the cascade reaction is useful for further structural modifications directed toward the total synthesis of fusidane and other triterpenes, and designed molecules intended for studying structure-activity relationships. (C) 2014 Elsevier Ltd. All rights reserved.