3,3′-二硫代双丙亚氨酸二甲酯 二盐酸盐

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 甲亚胺酸及其衍生物
• 中文名称: 3,3′-二硫代双丙亚氨酸二甲酯 二盐酸盐
• 中文别名: 3,3ˊ-二硫代双丙亚氨酸二甲酯二盐酸盐；3,3′-二硫代双丙亚氨酸二甲酯二盐酸盐；3,3-二硫代双丙亚氨酸二甲酯二盐酸盐；3,3'-二硫代双丙亚氨酸二甲酯二盐酸盐
• 英文名称: [3-[(3-Azaniumylidene-3-methoxypropyl)disulfanyl]-1-methoxypropylidene]azanium;dichloride
• 英文别名: [3-[(3-azaniumylidene-3-methoxypropyl)disulfanyl]-1-methoxypropylidene]azanium;dichloride
• 化学式: C8H18Cl2N2O2S2
• mdl: MFCD00043245
• 分子量: 309.3
• InChiKey: CQBCVFHLZAVNPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.98
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  117
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• METHOD OF PREPARING A SUPRAMOLECULAR COMPLEX CONTAINING A THERAPEUTIC AGENT AND A MULTI-DIMENSIONAL POLYMER NETWORK
  申请人：Davis Mark E.

  公开号：US20110144190A1

  公开（公告）日：2011-06-16

  A method of preparing a supramolecular complex containing at least one therapeutic agent and a multi-dimensional polymer network is described. A supramolecular complex prepared by a method of the invention is described. A method of treatment by administering a therapeutically effective amount of a supramolecular complex of the invention is also described. Such a supramolecular complex may be used as a delivery vehicle for various therapeutic agents.

  本发明涉及一种制备至少含有一种治疗剂和多维聚合物网络的超分子复合物的方法。本发明提出了一种通过本发明方法制备的超分子复合物。本发明还涉及一种通过给予本发明超分子复合物的治疗有效剂量来治疗的方法。这样的超分子复合物可以用作各种治疗剂的输送载体。
• COMPOSITIONS CONTAINING INCLUSION COMPLEXES
  申请人：Pun Suzie Hwang

  公开号：US20110182864A1

  公开（公告）日：2011-07-28

  The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:

  本发明提供一种含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还包含一个络合剂。聚合物与络合剂通过主客或客主相互作用形成包含物复合物。本发明的治疗组合物可用于输送治疗剂并治疗各种疾病。颗粒复合物的聚合物和络合剂均可用于向治疗组合物引入功能。本发明还涉及一种制备组合物的方法。该方法将治疗剂、具有主客或客主功能的聚合物和具有客或主功能的络合剂结合起来形成治疗组合物。络合剂与聚合物形成包含物复合物。本发明还涉及一种输送治疗剂的方法。根据该方法，在需要治疗的哺乳动物（例如人或动物）中，向其注射本发明的治疗组合物的治疗有效量。还公开了具有以下公式的化合物：
• COMPLEXING AGENTS FOR COMPOSITIONS CONTAINING INCLUSION COMPLEXES
  申请人：Pun Suzie Hwang

  公开号：US20110256104A1

  公开（公告）日：2011-10-20

  The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:

  本发明提供了一种含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还包含络合剂。聚合物与主-客或客-主相互作用以形成包含复合物。本发明的治疗组合物可用于传递治疗剂并治疗各种疾病。颗粒复合物的聚合物和络合剂均可用于向治疗组合物中引入功能。本发明还涉及一种制备组合物的方法。该方法将治疗剂，具有主或客功能的聚合物和具有客或主功能的络合剂结合以形成治疗组合物。络合剂与聚合物形成包含复合物。本发明还涉及一种传递治疗剂的方法。根据该方法，在需要治疗的哺乳动物（例如人或动物）中，向其注射本发明的治疗组合物的治疗有效量。还公开了具有以下公式的化合物：
• LINEAR CYCLODEXTRIN COPOLYMERS
  申请人：Davis Mark E.

  公开号：US20130184453A1

  公开（公告）日：2013-07-18

  Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.

  本文描述了线性环糊精共聚物和线性氧化环糊精共聚物，其中包含未氧化和/或氧化的环糊精基团集成到聚合物骨架中。本文还描述了制备这种共聚物的方法。本发明的线性环糊精共聚物和线性氧化环糊精共聚物可用作各种治疗剂的传递载体。
• Fluorometric assay of total IgE level and reagents therefor
  申请人：BioWhittaker, Inc.

  公开号：EP0119613A2

  公开（公告）日：1984-09-26

  A method for identifying and quantifying total IgE levels in patient serum by conjugating the IgE in the serum with anti-lgE antibody adhering to an insoluble support, conjugating the serum IgE with an enzyme labeled anti-IgE antibody, contacting the enzyme label with a solution of a substrate which will yield a fluorescent product in the presence of the enzyme, and measuring the level of fluorescence in the solution. Special reagents and their manufacture are also disclosed.

  一种鉴定和量化病人血清中总 IgE 水平的方法，其方法是将血清中的 IgE 与附着在不溶性支持物上的抗 lgE 抗体结合，将血清中的 IgE 与酶标记的抗 IgE 抗体结合，将酶标记与底物溶液接触，底物在酶的存在下会产生荧光产物，然后测量溶液中的荧光水平。此外，还公开了特殊试剂及其制造方法。

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