3-Ethyl-Δ³-chromen | 66898-31-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3-Ethyl-Δ³-chromen
• 英文别名: 3-ethyl-2H-chromene；3-ethyl-2H-chromene
• CAS: 66898-31-5
• 化学式: C₁₁H₁₂O
• 分子量: 160.216
• InChiKey: OWLPGJXIKDAJBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-乙基苯并吡喃-2-酮 在 silica gel 、 二异丁基氢化铝 作用下， 以 正己烷 、 均三甲苯 为溶剂， 反应 7.0h， 生成 3-Ethyl-Δ³-chromen
  参考文献：
  名称：

  由香豆素和色酮合成取代的2 H [1]苯并吡喃

  摘要：

  描述了一种取代2 H [1]苯并吡喃的简便方法，其中将三烷基铝化合物添加到香豆素或色酮中，并在二氧化硅存在下通过热环化反应将生成的Z -2-（3-羟基-1-丙烯基）苯酚转化凝胶至2 H [1]苯并吡喃。

  DOI：

  10.1002/jhet.5570200341

文献信息

• Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition
  申请人：Chao J. Hannguang

  公开号：US20070004677A1

  公开（公告）日：2007-01-04

  The present invention provides novel urea mimics and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, W, and R 6 are as defined herein. These compounds are selective inhibitors of the human P2Y 1 receptor which can be used as medicaments.

  本发明提供了新颖的尿素类似物和类似物，其化学式为（I）：或其立体异构体、互变异构体、药学上可接受的盐或溶剂形式，其中变量A、B、W和R6如本文所定义。这些化合物是人类P2Y1受体的选择性抑制剂，可用作药物。
• NOVEL NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF
  申请人：Kiyoto Taro

  公开号：US20100168418A1

  公开（公告）日：2010-07-01

  A nitrogen-containing heterocyclic compound represented by the general formula: wherein the dashed line represents a single bond or a double bond; R 1 , R 2 , R 3 , R 4 and R 5 independently represent a hydrogen atom, halogen atom, a lower alkyl, aryl, lower alkoxy or monocyclic heterocyclic group which may be substituted or the like; R 6 represents a lower alkyl, aryl, monocyclic heterocyclic, bicyclic heterocyclic or tricyclic heterocyclic group which may be substituted; X 1 represents a lower alkylene group or the like; X 2 represents a lower alkylene, lower alkenylene or lower alkynylene group which may be substituted; X 3 represents an oxygen atom, sulfur atom, a sulfinyl group, sulfonyl group or the like; Y 1 represents a bivalent cyclic group, containing a nitrogen, which may be substituted or the like; and Z 1 represents a nitrogen atom, a carbon atom which may be substituted or the like, or a salt thereof. The compound or salt has a potent antibacterial activity and a high safety, and is therefore useful as an excellent antibacterial agent.

  一种含氮杂环化合物，通式如下：其中虚线代表单键或双键；R1、R2、R3、R4和R5分别独立地代表氢原子、卤素原子、较低的烷基、芳基、较低的烷氧基或可以被取代的单环杂环基等；R6代表较低的烷基、芳基、单环杂环、双环杂环或三环杂环基，可以被取代；X1代表较低的烷基亚基或类似物；X2代表可以被取代的较低烷基、较低烯基或较低炔基亚基；X3代表氧原子、硫原子、亚砜基、磺酰基或类似物；Y1代表含有氮的二价环状基团，可以被取代或类似物；Z1代表氮原子、可以被取代的碳原子或类似物，或其盐。该化合物或盐具有强效的抗菌活性和高度的安全性，因此可用作优良的抗菌剂。
• QUINOLINONES AND QUINOXALINONES AS ANTIBACTERIAL COMPOSITION
  申请人：KIYOTO Taro

  公开号：US20120214990A1

  公开（公告）日：2012-08-23

  A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: which have a potent antibacterial activity and a high safety. Thus, the compounds are useful as antibacterial agents against gram-positive bacteria, gram-negative bacteria and drug resistant bacteria.

  一种含氮杂环化合物，或其药学上可接受的盐，其通式如下：具有强效的抗菌活性和高安全性。因此，这些化合物可用作抗革兰阳性菌、抗革兰阴性菌和抗药性菌的抗菌剂。
• PREPARATION AND METHOD OF ADMINISTERING VACCINE AND IONTOPHORESIS DEVICE USING THE PREPARATION
  申请人：Josai University Corporation

  公开号：EP2196212A1

  公开（公告）日：2010-06-16

  It is an object of the present invention to provide a method and an apparatus capable of noninvasively administrating vaccine through the skin, and thereby making the immune response activate. A drug product according to the present invention is characterized in that the drug product has a support medium, an electrode formed on the support medium and protected partly by an insulating material for avoiding a direct cutaneous contact, a vaccine containing layer for containing a vaccine, wherein the vaccine is an antigen for inducing an immune suppression protein. A method of administrating a vaccine according to the present invention is characterized in that the vaccine is administrated by the iontophoresis using the drug product according to the drug product of the present invention as an electrode. An apparatus for the iontophoresis according to the present invention is characterized in that the drug product according to the present invention is used as an electrode.

  本发明的目的是提供一种能够通过皮肤无创注射疫苗的方法和设备，从而激活免疫反应。根据本发明的一种药物产品，其特征在于该药物产品具有支撑介质、形成于支撑介质上并部分由绝缘材料保护以避免直接皮肤接触的电极、用于包含疫苗的含疫苗层，其中疫苗是用于诱导免疫抑制蛋白的抗原。根据本发明的一种施用疫苗的方法，其特征在于疫苗是通过使用根据本发明的药物产品作为电极的离子透入法施用的。根据本发明的离子透入疗法的设备，其特征在于根据本发明的药物产品被用作电极。
• Nitrogen-containing bicyclic compounds useful as antibacterial agents
  申请人：Toyama Chemical Co., Ltd.

  公开号：EP2468743A1

  公开（公告）日：2012-06-27

  A nitrogen-containing heterocyclic compound represented by the general formula: wherein the dashed line represents a single bond or a double bond; R1, R2, R3, R4 and R5 independently represent a hydrogen atom, halogen atom, a lower alkyl, aryl, lower alkoxy or monocyclic heterocyclic group which may be substituted or the like; R6 represents a lower alkyl, aryl, monocyclic heterocyclic, bicyclic heterocyclic or tricyclic heterocyclic group which may be substituted; X1 represents a lower alkylene group or the like; X2 represents a lower alkylene, lower alkenylene or lower alkynylene group which may be substituted; X3 represents an oxygen atom, sulfur atom, a sulfinyl group, sulfonyl group or the like; Y1 represents a bivalent cyclic group, containing a nitrogen, which may be substituted or the like; and Z1 represents a nitrogen atom, a carbon atom which may be substituted or the like, or a salt thereof. The compound or salt has a potent antibacterial activity and a high safety, and is therefore useful as an excellent antibacterial agent.

  一种由通式表示的含氮杂环化合物：其中虚线代表单键或双键；R1、R2、R3、R4和R5独立地代表氢原子、卤素原子、低级烷基、芳基、低级烷氧基或可被取代的单环杂环基团或类似基团；R6代表可被取代的低级烷基、芳基、单环杂环基团、双环杂环基团或三环杂环基团；X1代表低级亚烷基或类似基团；X2 代表可被取代的低级亚烷基、低级亚烯基或低级亚炔基； X3 代表氧原子、硫原子、亚砜基、磺酰基或类似物； Y1 代表可被取代的含氮的二价环基或类似物； Z1 代表氮原子、可被取代的碳原子或类似物，或其盐。该化合物或其盐具有很强的抗菌活性和很高的安全性，因此可用作优良的抗菌剂。