(S)-3-methyl-2-(1-phenylhex-5-en-3-ylamino)phenol | 922191-46-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (S)-3-methyl-2-(1-phenylhex-5-en-3-ylamino)phenol
• 英文别名: 3-Methyl-2-{[(3S)-1-phenylhex-5-en-3-yl]amino}phenol；3-methyl-2-[[(3S)-1-phenylhex-5-en-3-yl]amino]phenol
• CAS: 922191-46-6
• 化学式: C₁₉H₂₃NO
• 分子量: 281.398
• InChiKey: RPUVLGJMUKBOMR-QGZVFWFLSA-N

物化性质

• 沸点：
  470.3±45.0 °C(Predicted)
• 密度：
  1.072±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基-3-甲基苯酚 在 3 A molecular sieve 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 20.0h， 生成 (S)-3-methyl-2-(1-phenylhex-5-en-3-ylamino)phenol
  参考文献：
  名称：

  Phenol-Directed Enantioselective Allylation of Aldimines and Ketimines

  摘要：

  Phenols are effective directing and activating groups for our allylchlorosilane reagents, allowing the highly enantioselective allylation of a range of 2-aminophenol-derived aldimines. When the phenol is incorporated into the substrate ketimines may be allylated highly enantioselectively, leading to the experimentally simple synthesis of a range of tertiary carbinamine structures.

  DOI：

  10.1021/ol062589y

文献信息

• Phenol-Directed Enantioselective Allylation of Aldimines and Ketimines
  作者：Philippe M. A. Rabbat、S. Corey Valdez、James L. Leighton

  DOI：10.1021/ol062589y

  日期：2006.12.1

  Phenols are effective directing and activating groups for our allylchlorosilane reagents, allowing the highly enantioselective allylation of a range of 2-aminophenol-derived aldimines. When the phenol is incorporated into the substrate ketimines may be allylated highly enantioselectively, leading to the experimentally simple synthesis of a range of tertiary carbinamine structures.