(R)-2-[1-(furan-2-yl)but-3-enylamino]phenol | 922191-50-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (R)-2-[1-(furan-2-yl)but-3-enylamino]phenol
• 英文别名: 2-{[(1R)-1-(Furan-2-yl)but-3-en-1-yl]amino}phenol；2-[[(1R)-1-(furan-2-yl)but-3-enyl]amino]phenol
• CAS: 922191-50-2
• 化学式: C₁₄H₁₅NO₂
• 分子量: 229.279
• InChiKey: RXJNLFBXXMKKOI-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  45.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  糠醛 、 alkaline earth salt of/the/ methylsulfuric acid 以 乙醇 、 二氯甲烷 为溶剂， 反应 16.0h， 生成 (R)-2-[1-(furan-2-yl)but-3-enylamino]phenol
  参考文献：
  名称：

  Phenol-Directed Enantioselective Allylation of Aldimines and Ketimines

  摘要：

  Phenols are effective directing and activating groups for our allylchlorosilane reagents, allowing the highly enantioselective allylation of a range of 2-aminophenol-derived aldimines. When the phenol is incorporated into the substrate ketimines may be allylated highly enantioselectively, leading to the experimentally simple synthesis of a range of tertiary carbinamine structures.

  DOI：

  10.1021/ol062589y

文献信息

• Phenol-Directed Enantioselective Allylation of Aldimines and Ketimines
  作者：Philippe M. A. Rabbat、S. Corey Valdez、James L. Leighton

  DOI：10.1021/ol062589y

  日期：2006.12.1

  Phenols are effective directing and activating groups for our allylchlorosilane reagents, allowing the highly enantioselective allylation of a range of 2-aminophenol-derived aldimines. When the phenol is incorporated into the substrate ketimines may be allylated highly enantioselectively, leading to the experimentally simple synthesis of a range of tertiary carbinamine structures.