1-(6-Heptylpyridin-2-yl)-1,4-diazepane | 120145-17-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(6-Heptylpyridin-2-yl)-1,4-diazepane
• CAS: 120145-17-7
• 化学式: C₁₇H₂₉N₃
• 分子量: 275.437
• InChiKey: YBYCSVWENQMWGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  28.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲基-6-氯吡啶 在 lithium diisopropyl amide 作用下， 以 正丁醇 为溶剂， 反应 69.0h， 生成 1-(6-Heptylpyridin-2-yl)-1,4-diazepane
  参考文献：
  名称：

  6-Alkyl-N,N-disubstituted-2-pyridinamines as anticonvulsant agents

  摘要：

  The anticonvulsant effect of a series of 6-alkyl-N,N-disubstituted-2-pyridinamines is described. An investigation was carried out to optimize the anticonvulsant activity and reduce behavioral side effects in this series. Three compounds (7, 8, 10; Table I) were selected from initial screening for a more complete pharmacological evaluation. While each of these compounds was a potent anticonvulsant agent with ED50 values from 5 to 10 mg/kg, the activity was accompanied by significant behavioral side effects including decreased spontaneous locomotion, ataxia, and ptosis.

  DOI：

  10.1021/jm00126a015

文献信息

• 6-Alkyl-N,N-disubstituted-2-pyridinamines as anticonvulsant agents
  作者：Michael R. Pavia、Charles P. Taylor、Sandra J. Lobbestael

  DOI：10.1021/jm00126a015

  日期：1989.6

  The anticonvulsant effect of a series of 6-alkyl-N,N-disubstituted-2-pyridinamines is described. An investigation was carried out to optimize the anticonvulsant activity and reduce behavioral side effects in this series. Three compounds (7, 8, 10; Table I) were selected from initial screening for a more complete pharmacological evaluation. While each of these compounds was a potent anticonvulsant agent with ED50 values from 5 to 10 mg/kg, the activity was accompanied by significant behavioral side effects including decreased spontaneous locomotion, ataxia, and ptosis.