azacycloheptadecane | 295-98-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: azacycloheptadecane
• 英文别名: Azacycloheptadecan
• CAS: 295-98-7
• 化学式: C₁₆H₃₃N
• 分子量: 239.445
• InChiKey: TZMYTBFJOAVOHS-UHFFFAOYSA-N

物化性质

• 沸点：
  126-127 °C
• 密度：
  0.8470 g/cm3(Temp: 72 °C)
• 熔点：
  58-59 °C

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  azacycloheptadecane 、 聚合甲醛 在 甲酸 作用下， 生成 1-methyl-azacycloheptadecane
  参考文献：
  名称：

  Ruzicka; Salomon; Meyer, Helvetica Chimica Acta, 1937, vol. 20, p. 122

  摘要：

  DOI：
• 作为产物：
  描述：

  cyclohexadecanone oxime 在 lithium aluminium tetrahydride 、 乙醚 、 硫酸 、 水 作用下， 生成 azacycloheptadecane
  参考文献：
  名称：

  Ruzicka et al., Helvetica Chimica Acta, 1949, vol. 32, p. 552

  摘要：

  DOI：

文献信息

• [EN] TRICYCLIC PROTEIN KINASE INHIBITORS<br/>[FR] INHIBITEURS TRICYCLIQUES DE PROTEINE KINASE
  申请人：AMERICAN HOME PROD

  公开号：WO2001047892A1

  公开（公告）日：2001-07-05

  This invention provides compounds of formula (1) which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.

  本发明提供了一种式子为(1)的化合物，它们可用作蛋白酪氨酸激酶的抑制剂并具有抗增殖作用。
• Solubilized anionic polymerization initiators and products therefrom
  申请人：BRIDGESTONE CORPORATION

  公开号：EP0626278A1

  公开（公告）日：1994-11-30

  The present invention is directed toward anionic polymerization initiators which are soluble in acyclic alkane solvents. The initiators include a solubilized lithio amine having the general formula (A)Li(SOL)y. SOL is a solubilizing component and A is an alkyl, dialkyl or cycloalkyl amine radical or a cyclic amine and y is from about 1 to 4. The cyclic amine has an alkylene, oxy- or amino-alkylene group having from about 3 to about 16 methylene groups. The invention is also directed toward polymers and other products made using the initiator, and methods therefor. Further, the invention contemplates a polymer, a polymer composition and products therefrom, which include a functional group from the reaction product of an amine and an organolithium compound. The resulting polymers may be terminated with a terminating, coupling or linking agent, which may provide the polymer wtih a multifunctionality.

  本发明涉及可溶于无环烷烃溶剂的阴离子聚合引发剂。这种引发剂包括通式为 (A)Li(SOL)y 的增溶亚锂胺。SOL 是增溶组分，A 是烷基、二烷基或环烷基胺基或环胺，y 是约 1 至 4。环胺具有亚烷基、氧烷基或氨基烷基，其亚甲基数约为 3 至 16。本发明还涉及使用该引发剂制造的聚合物和其他产品及其方法。此外，本发明还考虑了一种聚合物、聚合物组合物及其产品，其中包括来自胺和有机锂化合物反应产物的官能团。由此得到的聚合物可以用终止剂、偶联剂或连接剂终止，从而使聚合物具有多功能性。
• Amine containing polymers and products therefrom
  申请人：BRIDGESTONE CORPORATION

  公开号：EP0709408A1

  公开（公告）日：1996-05-01

  A functionalized polymer includes a polymer chain carrying at least one functional group selected from alkyl, dialkyl and cycloalkyl amine radicals having the general formula and cyclic amine radicals having the general formula where R₁ is an alkyl, cycloalkyl or aralkyl having from 1 to about 12 carbon atoms, and R₂ is an alkylene, substituted alkylene, oxy- or N-alkylamino-alkylene group having from about 3 to about 16 methylene groups. The invention also provides products based upon such polymers.

  官能化聚合物包括一条聚合物链，其中至少带有一个官能团，该官能团选自烷基、 二烷基和环烷基胺自由基，其通式为 和具有通式的环胺基 其中 R₁ 是具有 1 至约 12 个碳原子的烷基、环烷基或芳烷基，R₂ 是具有约 3 至约 16 个亚甲基的亚烷基、取代亚烷基、氧基亚烷基或 N-亚烷基氨基亚烷基。本发明还提供了基于此类聚合物的产品。
• Anionic polymerization initiators and reduced hysteresis products therefrom
  申请人：BRIDGESTONE CORPORATION

  公开号：EP0718321A1

  公开（公告）日：1996-06-26

  The present invention is directed toward anionic polymerization employing lithio amines mixed with an organic alkali metal compound and optionally, a chelating reagent. The lithio amines have the general formula (A)Li(SOL)y, where SOL is a solubilizing component, A is an alkyl, dialkyl, cycloalkyl or dicycloalkyl amine radical or a cyclic amine, and y is 0 or is from about 0.5 to about 3. The invention is also directed toward polymers and other products made using the initiator, and methods therefor. Further, the invention contemplates a polymer, a polymer composition and products therefrom, which include a functional group from the reaction product of an amine and an organolithium compound. The resulting polymers may be terminated with a terminating, coupling or linking agent, which may provide the polymer with a multifunctionality.

  本发明的目的是利用二元胺与有机碱金属化合物以及螯合试剂混合进行阴离子聚合。亚锂胺的通式为 (A)Li(SOL)y，其中 SOL 为增溶组分，A 为烷基、二烷基、环烷基或二环烷基胺基或环胺，y 为 0 或约 0.5 至约 3。本发明还涉及使用引发剂制造的聚合物和其他产品及其方法。此外，本发明还考虑了一种聚合物、聚合物组合物及其产品，其中包括来自胺和有机锂化合物反应产物的官能团。得到的聚合物可以用终止剂、偶联剂或连接剂终止，从而使聚合物具有多功能性。
• Soluble anionic polymerization initiators and products therefrom
  申请人：BRIDGESTONE CORPORATION

  公开号：EP0741148A1

  公开（公告）日：1996-11-06

  An acyclic alkane soluble anionic polymerization initiator includes a mixture of from about 90 to about 10 parts by weight of a lithio amine having the general formula A1Li and from about 10 to about 90 parts by weight of at least one other lithio amine having the general formula A2Li. A1 and A2 are selected from the dialkyl, alkyl, cycloalkyl and dicycloalkyl amine radicals and cyclic amine radicals. There is also provided a method of forming a mixture of anionic polymerization initiators, a functionalized polymer and a method of forming a functionalized polymer.

  一种无环烷烃可溶性阴离子聚合引发剂包括按重量计约 90 至约 10 份具有通式 A1Li 的亚锂胺和按重量计约 10 至约 90 份具有通式 A2Li 的至少另一种亚锂胺的混合物。A1 和 A2 选自二烷基、烷基、环烷基和二环烷基胺基和环胺基。本发明还提供了一种形成阴离子聚合引发剂混合物、官能化聚合物和形成官能化聚 合物的方法。