S-(1-cyclopropylethyl) S-methyl dithiocarbonate | 111661-14-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫基化合物
• 英文名称: S-(1-cyclopropylethyl) S-methyl dithiocarbonate
• 英文别名: Dithiolkohlensaeure-methyl-<1-cyclopropyl-ethyl-(1)>-ester；Dithiolkohlensaeure-methyl-(1-cyclopropyl-ethyl-(1))-ester；1-Cyclopropylethylsulfanyl(methylsulfanyl)methanone
• CAS: 111661-14-4
• 化学式: C₇H₁₂OS₂
• 分子量: 176.304
• InChiKey: SVZFSFNAJDVABH-UHFFFAOYSA-N

物化性质

• 沸点：
  236-237 °C
• 密度：
  1.0908 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  67.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  S-(1-cyclopropylethyl) S-methyl dithiocarbonate 生成 1-Mercapto-1-cyclopropyl-ethan
  参考文献：
  名称：

  Ionic Polymerization. XVI. Reactions of 1-Cyclopropylethanol-Vinylcyclopropane^1-3

  摘要：

  DOI：

  10.1021/ja01503a036
• 作为产物：
  描述：

  O-(1-cyclopropylethyl)-S-methyl carbonodithioate 以 formamide 为溶剂， 生成 S-(1-cyclopropylethyl) S-methyl dithiocarbonate
  参考文献：
  名称：

  黄原酸酯的硫酮-硫醇重排速率与溶剂垢的相关性。通过Kamlet-Taft参数π ∗，α和β分析反应行为

  摘要：

  通过分析O-（2-烯基）（1a-c），O-（1-环丙基乙基）（1d）和O-（2-甲基硫乙基）（1e）S-甲基黄药的硫酮到硫醇重排速率。Kamlet-Taft方程。结果表明，溶剂极性和溶剂氢键给定能力（酸度）在硫酮到硫醇的重排反应中起作用。在1e的情况下，发现该反应受溶剂酸度影响并且受溶剂极性增加的阻碍。

  DOI：

  10.1016/s0040-4020(98)00438-4

文献信息

• Phenol-Catalyzed Thione-Thiol Rearrangement of Xanthates and Modified Intermediate Neglect of Differential Overlap(MINDO/3) Analysis of the Reaction Mechanism.
  作者：Kazunobu HARANO、Hideo KIYONAGA、Takuzo HISANO

  DOI：10.1248/cpb.40.2654

  日期：——

  S-Alkyl dithiocarbonates (xanthates) of alkanols containing strained σ bonds underwent rearrangement to S, S-dialkyl dithiocarbonates, catalyzed by phenolic compounds. The reaction followed first-order kinetics and the rates were affected by the acidity of the phenols. The rate contants are proportional to the square of the concentration of phenol.The modified intermediate neglect of differential overlap (MINDO/3) geometry optimization indicates that S, S-dialkyl dithiocarbonate is ca. 9 kcal/mol more stable than O, S-dialkyl xanthate. The thione-thiol rearrangement and sulfide formation reactions were analyzed by MO simulations. The experimental results can be well reproduced by the MINDO/3 method rather than the modified neglect of diatomic overlap (MNDO) method. Based on these data, the reaction mechanism is discussed.

  含有σ键的烷醇的S-烷基二硫代碳酸酯（黄药）在酚类化合物的催化下发生重排，生成S，S-二烷基二硫代碳酸酯。该反应遵循一级动力学，速率受酚类化合物的酸度影响。速率常数与酚类化合物浓度的平方成正比。对忽略差分重叠（MINDO/3）几何优化的修正中间体表明，S，S-二烷基二硫代碳酸酯比O，S-二烷基黄药稳定约9 kcal/mol。硫醇-硫醚重排和硫化物形成反应通过MO模拟进行了分析。实验结果可以通过MINDO/3方法而不是修正的忽略二原子重叠（MNDO）方法很好地再现。基于这些数据，讨论了反应机理。
• Harano, Kazunobu; Kiyonaga, Hideo; Hisano, Takuzo, Chemical and pharmaceutical bulletin, 1987, vol. 35, # 4, p. 1388 - 1396
  作者：Harano, Kazunobu、Kiyonaga, Hideo、Hisano, Takuzo

  DOI：——

  日期：——
• HARANO KAZUNOBU; KIYONAGA HIDEO; HISANO TAKUZO, CHEM. AND PHARM. BULL., 35,(1987) N 4, 1388-1396
  作者：HARANO KAZUNOBU、 KIYONAGA HIDEO、 HISANO TAKUZO

  DOI：——

  日期：——
• Ionic Polymerization. XVI. Reactions of 1-Cyclopropylethanol-Vinylcyclopropane^1-3
  作者：C. G. Overberger、A. E. Borchert

  DOI：10.1021/ja01503a036

  日期：1960.9
• Correlation of thione-to-thiol rearrangement rates of xanthates with solvent scales. Analysis of the reaction behavior by the Kamlet-Taft parameters, , α and β
  作者：Masashi Eto、Okiyasu Tajiri、Hidetoshi Nakagawa、Kazunobu Harano

  DOI：10.1016/s0040-4020(98)00438-4

  日期：1998.7

  O-(2-methylthioethyl) (1e) S-methyl xanthates were analyzed by the Kamlet-Taft equation. The results indicate that solvent polarity and solvent hydrogen-bond donation ability (acidity) are operative in the thione-to-thiol rearrangement reactions. In the case of 1e, the reaction is found to be influenced by solvent acidity and retarded by the increase of the solvent polarity.

  通过分析O-（2-烯基）（1a-c），O-（1-环丙基乙基）（1d）和O-（2-甲基硫乙基）（1e）S-甲基黄药的硫酮到硫醇重排速率。Kamlet-Taft方程。结果表明，溶剂极性和溶剂氢键给定能力（酸度）在硫酮到硫醇的重排反应中起作用。在1e的情况下，发现该反应受溶剂酸度影响并且受溶剂极性增加的阻碍。