2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol | 1234702-03-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol
• 英文别名: 2-[2-(2-Hydroxyethylamino)ethyliminomethyl]-4-nitrophenol；2-[2-(2-hydroxyethylamino)ethyliminomethyl]-4-nitrophenol
• CAS: 1234702-03-4
• 化学式: C₁₁H₁₅N₃O₄
• 分子量: 253.258
• InChiKey: VQZWCEYAVKKKHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  111
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  羟乙基乙二胺 、 5-硝基水杨醛 以 甲醇 为溶剂， 反应 0.5h， 以91%的产率得到2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol
  参考文献：
  名称：

  Synthesis, structures, and urease inhibitory activities of three copper(II) and zinc(II) complexes with 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol

  摘要：

  In order to explore novel urease inhibitors, three new mononuclear complexes of Cu(II) and Zn(II) with Schiff base 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol have been prepared and structurally characterized by X-ray crystallography. Among the three complexes, two Cu(II) complexes show strong urease inhibitory activities with the IC50 values being much lower than that of the acetohydroxamic acid, while the Zn(II) complex shows no activity at the concentration of 100 mu M. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.03.012

文献信息

• Synthesis, structures, and urease inhibitory activities of three copper(II) and zinc(II) complexes with 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol
  作者：Zhong-Lu You、Li-Li Ni、Da-Hua Shi、Shun Bai

  DOI：10.1016/j.ejmech.2010.03.012

  日期：2010.7

  In order to explore novel urease inhibitors, three new mononuclear complexes of Cu(II) and Zn(II) with Schiff base 2-[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol have been prepared and structurally characterized by X-ray crystallography. Among the three complexes, two Cu(II) complexes show strong urease inhibitory activities with the IC50 values being much lower than that of the acetohydroxamic acid, while the Zn(II) complex shows no activity at the concentration of 100 mu M. (C) 2010 Elsevier Masson SAS. All rights reserved.