F3368-0119 | 65425-27-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: F3368-0119
• 英文别名: 1-[1]naphthyloxy-3-pyrrolidino-propan-2-ol；1-(Naphthalen-1-yloxy)-3-pyrrolidin-1-yl-propan-2-ol；1-naphthalen-1-yloxy-3-pyrrolidin-1-ylpropan-2-ol
• CAS: 65425-27-6
• 化学式: C₁₇H₂₁NO₂
• 分子量: 271.359
• InChiKey: DAUPQTWASFZPMJ-UHFFFAOYSA-N

物化性质

• 沸点：
  463.0±30.0 °C(Predicted)
• 密度：
  1.158±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 3-(1-萘氧基)-1,2-环氧丙烷 在 cerium(III) chloride heptahydrate 、 甘油 作用下， 反应 0.75h， 以88%的产率得到F3368-0119
  参考文献：
  名称：

  Glycerine and CeCl3˙7H2O: An Efficient and Recyclable Reaction Medium for Ring Opening of Epoxides with Thioamides and Amines

  摘要：

  环氧乙烷与一系列硫酰胺和胺迅速发生开环反应，生成相应的β-氨基醇衍生物。反应采用甘油和氯化铈(III)作为可回收反应介质进行。所有反应均在室温下进行，产物收率极佳。

  DOI：

  10.1055/s-0030-1258366

文献信息

• Antidepressant naphthyloxy piperidino and pyrrolidino propanol ethers
  申请人：Ayerst McKenna and Harrison Limited

  公开号：US04170653A1

  公开（公告）日：1979-10-09

  Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 together with the nitrogen atom to which they are joined form a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.

  本文揭示了公式## STR1##的化合物，其中Ar为苯或1-萘基; R.sup.1为氢或低碳基; R.sup.2和R.sup.3与它们连接的氮原子一起形成从1-吡咯啉基，哌啶基，吗啉基和4-（低碳基）-1-哌嗪基中选择的杂环胺基。这些化合物是抗抑郁剂，并且还揭示了它们的制备和使用方法。
• 3-Aryloxy-2(4-loweralkyl-1-piperazinyl)propanols, their alkylethers, and
  申请人：Ayerst McKenna and Harrison Ltd.

  公开号：US04060613A1

  公开（公告）日：1977-11-29

  Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 together with the nitrogen atom to which they are joined form a hyterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.

  本文披露了以下公式的化合物：##STR1## 其中Ar是苯或1-萘基；R.sup.1是氢或低碳基；而R.sup.2和R.sup.3与它们连接的氮原子一起形成从以下组中选择的杂环胺基：1-吡咯烷基，哌啶基，吗啉基和4-(低碳基)-1-哌嗪基。这些化合物是抗抑郁剂，还披露了它们的制备和使用方法。
• Aryloxy propyldiamines
  申请人：Ayerst, McKenna and Harrison Limited

  公开号：US04140779A1

  公开（公告）日：1979-02-20

  Disclosed herein are compounds of the formula ##STR1## in which Ar is l-naphthyl; R.sup.1 and R.sup.2 are either the same or different selected from the group consisting of hydrogen or lower alkyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are joined form a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidine, morpholine and 4-(lower alkyl)-1-piperazinyl; and R.sup.3 and R.sup.4 are either the same or different selected from the group consisting of hydrogen or lower alkyl, or R.sup.3 and R.sup.4 together with the nitrogen to which they are joined represent a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl; or a therapeutically acceptable acid addition salt thereof. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.

  本文披露了公式##STR1##中的化合物，其中Ar为1-萘基; R.sup.1和R.sup.2从氢或较低的烷基中选择，可以相同也可以不同，或者R.sup.1和R.sup.2与它们连接的氮原子一起形成从1-吡咯烷基、哌啶、吗啉和4-(较低烷基)-1-哌嗪中选择的杂环胺基; R.sup.3和R.sup.4从氢或较低的烷基中选择，可以相同也可以不同，或者R.sup.3和R.sup.4与它们连接的氮原子一起代表从1-吡咯啉基、哌啶基、吗啉基和4-(较低烷基)-1-哌嗪中选择的杂环胺基; 或其治疗上可接受的酸盐。这些化合物是抗抑郁剂，还披露了它们的制备和使用方法。
• Non-hydrophobic compounds for use in treating metastasis and/or cartilage defect
  申请人：Friedrich-Alexander-Universität Erlangen-Nürnberg

  公开号：US10828281B2

  公开（公告）日：2020-11-10

  The present invention is directed to compounds, tautomers, stereoisomers, and chemically modified compounds thereof, and their use in preventing and/or treating tumors of metastasis and/or cartilage defect, and to a pharmaceutical composition comprising such compound.

  本发明涉及其化合物、同系物、立体异构体和化学修饰化合物，及其在预防和/或治疗肿瘤转移和/或软骨缺损中的用途，以及包含此类化合物的药物组合物。
• 1-Aryloxy-3-[N-heterocyclicamino]-2-propanols¹
  作者：C. B. Pollard、R. W. Ingwalson

  DOI：10.1021/ja01617a083

  日期：1955.6