JBL-43 | 1014718-67-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: JBL-43
• 英文别名: 5-bromo-3-phenyl-1-benzofuran-2-carboxylic acid
• CAS: 1014718-67-2
• 化学式: C₁₅H₉BrO₃
• 分子量: 317.139
• InChiKey: CHCDVUXOXSCLBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-溴-2-羟基二苯甲酮 在 potassium carbonate 、 sodium hydroxide 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 0.5h， 生成 JBL-43
  参考文献：
  名称：

  Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels

  摘要：

  Improved experimental conditions were carried out for the preparation in high yields of some 3-phenyl-1-benzofuran-2-carboxylic acids, potent inhibitors of C1C-K chloride channels. A one-pot condensation-cyclization was set up starting from different 2-hydroxybenzophenones whose reactivity was significantly affected from the electronic properties of their substituents.

  DOI：

  10.3987/com-10-12070

文献信息

• Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels
  作者：Fulvio Loiodice、Luca Piemontese、Giuseppe Carbonara、Giuseppe Fracchiolla、Antonio Laghezza、Paolo Tortorella

  DOI：10.3987/com-10-12070

  日期：——

  Improved experimental conditions were carried out for the preparation in high yields of some 3-phenyl-1-benzofuran-2-carboxylic acids, potent inhibitors of C1C-K chloride channels. A one-pot condensation-cyclization was set up starting from different 2-hydroxybenzophenones whose reactivity was significantly affected from the electronic properties of their substituents.