CCR4 | 864289-85-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: CCR4
• 英文别名: N-cycloheptyl-6,7-dimethoxy-2-(4-piperidin-1-ylpiperidin-1-yl)quinazolin-4-amine
• CAS: 864289-85-0
• 化学式: C₂₇H₄₁N₅O₂
• 分子量: 467.655
• InChiKey: WYVBISCFCHREDA-UHFFFAOYSA-N

物化性质

• 溶解度：
  溶于二甲基亚砜

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-哌啶基哌啶 、 2-chloro-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine 以 甲苯 为溶剂， 生成 CCR4
  参考文献：
  名称：

  [EN] QUINAZOLINE COMPOUNDS AND THEIR USE IN THERAPY
  [FR] COMPOSÉS DE QUINAZOLINE ET LEUR UTILISATION THÉRAPEUTIQUE

  摘要：

  本发明涉及式（I）的喹唑啉化合物，其为组蛋白赖氨酸甲基转移酶（HKMTase）EZH2的抑制剂，并且涉及使用这些化合物作为药物，特别是在治疗某种疾病或紊乱中，EZH2的抑制提供治疗或预防效果。

  公开号：

  WO2013140148A1

文献信息

• [EN] QUINAZOLINE COMPOUNDS AND THEIR USE IN THERAPY<br/>[FR] COMPOSÉS DE QUINAZOLINE ET LEUR UTILISATION THÉRAPEUTIQUE
  申请人：IMP INNOVATIONS LTD

  公开号：WO2013140148A1

  公开（公告）日：2013-09-26

  This invention relates to quinazoline compounds of Formula (I) which are inhibitors of the histone lysine methyltransferase (HKMTase) EZH2, and to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of EZH2 provides a therapeutic or prophylactic effect.

  本发明涉及式（I）的喹唑啉化合物，其为组蛋白赖氨酸甲基转移酶（HKMTase）EZH2的抑制剂，并且涉及使用这些化合物作为药物，特别是在治疗某种疾病或紊乱中，EZH2的抑制提供治疗或预防效果。
• Quinazoline Compounds And Their Use In Therapy
  申请人：Imperial Innovations Limited

  公开号：US20150057263A1

  公开（公告）日：2015-02-26

  This invention relates to quinazoline compounds of Formula (I) which are inhibitors of the histone lysine methyltransferase (HKMTase) EZH2, and to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of EZH2 provides a therapeutic or prophylactic effect.

  本发明涉及公式（I）的喹嗪化合物，其是组蛋白赖氨酸甲基转移酶（HKMTase）EZH2的抑制剂，并且涉及将这些化合物用作药物的用途，特别是用于治疗抑制EZH2具有治疗或预防效果的疾病或障碍。
• QUINAZOLINE COMPOUNDS AND THEIR USE IN THERAPY
  申请人：Imperial College Innovations Limited

  公开号：EP2828250B1

  公开（公告）日：2021-03-10
• US9932317B2
  申请人：——

  公开号：US9932317B2

  公开（公告）日：2018-04-03
• Discovery of potent CCR4 antagonists: Synthesis and structure–activity relationship study of 2,4-diaminoquinazolines
  作者：Kazuhiro Yokoyama、Noriko Ishikawa、Susumu Igarashi、Noriyuki Kawano、Kazuyuki Hattori、Takahiro Miyazaki、Shin-ichi Ogino、Yuzo Matsumoto、Makoto Takeuchi、Mitsuaki Ohta

  DOI：10.1016/j.bmc.2008.05.036

  日期：2008.7

  A new series of quinazolines that function as CCR4 antagonists were discovered during the screening of our corporate compound libraries. Subsequent compound optimization elucidated the structure-activity relationships and led the identification of 2-(1,4'-bipiperidine-10-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4- amine 14a, which showed potent inhibition in the [S-35] GTPcS-binding assay (IC50 = 18 nM). This compound also inhibited the chemotaxis of human and mouse CCR4-expressing cells ( IC50 = 140 nM, 39 nM). (c) 2008 Elsevier Ltd. All rights reserved.